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中华消化病与影像杂志(电子版) ›› 2017, Vol. 07 ›› Issue (03) : 97 -100. doi: 10.3877/cma.j.issn.2095-2015.2017.03.001

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炎症性肠病肠外表现的诊治策略
葛文松1,()   
  1. 1. 200092 上海交通大学医学院附属新华医院消化内科
  • 收稿日期:2017-04-07 出版日期:2017-06-01
  • 通信作者: 葛文松
  • 基金资助:
    国家自然科学基金(81200279)

Extraintestinal manifestations of inflammatory bowel disease: diagnosis and treatment

Wensong Ge1,()   

  1. 1. Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School Medicine, Shanghai 200092, China
  • Received:2017-04-07 Published:2017-06-01
  • Corresponding author: Wensong Ge
  • About author:
    Corresponding author: Ge Wensong, Email:
引用本文:

葛文松. 炎症性肠病肠外表现的诊治策略[J]. 中华消化病与影像杂志(电子版), 2017, 07(03): 97-100.

Wensong Ge. Extraintestinal manifestations of inflammatory bowel disease: diagnosis and treatment[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(03): 97-100.

炎症性肠病(inflammatory bowel disease,IBD)是一组病因不明的慢性非特异性肠道炎症性疾病,包括Crohn病(Crohn′s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC),其临床表现多样,不仅累及肠道,亦可出现多种肠外表现(extraintestinal manifestations,EIMs),易造成误诊误治,及时诊断及合理治疗能够改善患者的病情和生活质量,本文就IBD常见EIMs的诊断和治疗策略进行探讨。

Objective

Inflammatory bowel disease(IBD)is a chronic and non-specific inflammatory disease with unknown etiology, which comprises Crohn disease(CD)and ulcerative colitis(UC). The clinical manifestations of IBD are variable.It predominantly affects the intestinal system, but it is associated with a large number of extraintestinal manifestations(EIMs), and this may lead to misdiagnosis or mistreatment.Timely diagnosis and reasonable treatment can improve the patient′s condition and the quality of life.In this paper, the diagnostic and treatment strategies about EIMs of IBD are discussed.

1
Ott C, Scholmerich J. Extraintestinal manifestations and complications in IBD[J]. Nat Rev Gastroenterol Hepatol, 2013, 10(10): 585-595.
2
Orchard TR, Wordsworth BP, Jewell DP.Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history[J]. Gut, 1998, 42(3): 387-391.
3
Salvarani C, Vlachonikolis IG, van der Heijde DM, et al.Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients[J]. Scand J Gastroenterol, 2001, 36(12): 1307-1313.
4
Peeters H, Vander Cruyssen B, Mielants H, et al.Clinical and genetic factors associated with sacroiliitis in Crohn′s disease[J]. J Gastroenterol Hepatol, 2008, 23(1): 132-137.
5
Puhakka KB, Jurik AG, Schi?ttz-Christensen B, et al.MRI abnormalities of sacroiliac joints in early spondylarthropathy: a 1-year follow-up study[J]. Scand J Rheumatol, 2004, 33(5): 332-338.
6
Peluso R, Manguso F, Vitiello M, et al.Management of arthropathy in inflammatory bowel diseases[J]. Ther Adv Chronic Dis, 2015, 6(2): 65-77.
7
Braun J, Baraliakos X, Listing J, et al.Persistent clinical efficacy and safety of anti-tumour necrosis factor alpha therapy with infliximab in patients with ankylosing spondylitis over 5 years: evidence for different types of response[J]. Ann Rheumat Dis, 2008, 67(3): 340-345.
8
Requena L, Sanchez Yus E. Erythema nodosum[J]. Semin Cutan Med Surg, 2007, 26(2): 114-125.
9
Andrisani G, Guidi L, Papa A, et al.Anti-TNF alpha therapy in the management of extraintestinal manifestation of inflammatory bowel disease[J]. Eur Rev Med Pharmacol Sci, 2012, 16(7): 890-901.
10
Ruocco E, Sangiuliano S, Gravina AG, et al.Pyoderma gangrenosum: an updated review[J]. J Eur Acad Dermatol Venereol, 2009, 23(9): 1008-1017.
11
Lakatos PL, Lakatos L, Kiss LS, et al.Treatment of extraintestinal manifestations in inflammatory bowel disease[J]. Digestion, 2012, 86 Suppl 1: 28-35.
12
Ljung T, Staun M, Grove O, et al.Pyoderma gangrenosum associated with crohn disease: effect of TNF-alpha blockade with infliximab[J]. Scand J Gastroenterol, 2002, 37(9): 1108-1110.
13
Reinshagen M. Osteoporosis in inflammatory bowel disease[J]. J Crohns Colitis, 2008, 2(3): 202-207.
14
Bischoff-Ferrari HA, Willett WC, Wong JB, et al.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials[J]. JAMA, 2005, 293(18): 2257-2264.
15
Soo I, Siffledeen J, Siminoski K, et al.Risedronate improves bone mineral density in Crohn′s disease: a two year randomized controlled clinical trial[J]. J Crohns Colitis, 2012, 6(7): 777-786.
16
Eaton JE, Talwalkar JA, Lazaridis KN, et al.Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management[J]. Gastroenterology, 2013, 145(3): 521-536.
17
Braden B, Halliday J, Aryasingha S, et al.Risk for colorectal neoplasia in patients with colonic Crohn′s disease and concomitant primary sclerosing cholangitis[J]. Clin Gastroenterol Hepatol, 2012, 10(3): 303-308.
18
Lindor KD, Kowdley KV, Luketic VA, et al.High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis[J]. Hepatology, 2009, 50(3): 808-814.
19
Higgins PD, Skup M, Mulani PM, et al.Increased risk of venous thromboembolic events with corticosteroid vs biologic therapy for inflammatory bowel disease[J]. Clin Gastroenterol Hepatol, 2015, 13(2): 316-321.
20
Chong LY, Fenu E, Stansby G, et al.Management of venous thromboembolic diseases and the role of thrombophilia testing: summary of NICE guidance[J]. BMJ, 2012, 344: e3979.
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