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中华消化病与影像杂志(电子版) ›› 2018, Vol. 08 ›› Issue (01) : 19 -23. doi: 10.3877/cma.j.issn.2095-2015.2018.01.005

所属专题: 文献

循证医学

窄带成像技术结合显微放大内镜对诊断幽门螺杆菌感染的Meta分析
张岚1, 殷云勤2,()   
  1. 1. 030001 太原,山西医科大学
    2. 030001 太原,山西医科大学第一医院消化科
  • 收稿日期:2016-08-10 出版日期:2018-02-01
  • 通信作者: 殷云勤

Detection of Helicobacter pylori infection by narrow-band imaging with magnification gastroscopy: a Meta analysis

Lan Zhang1, Yunqin Yin2,()   

  1. 1. Shanxi Medical University, Taiyuan 030001, China
    2. Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2016-08-10 Published:2018-02-01
  • Corresponding author: Yunqin Yin
  • About author:
    Corresponding author: Yin Yunqin, Email:
引用本文:

张岚, 殷云勤. 窄带成像技术结合显微放大内镜对诊断幽门螺杆菌感染的Meta分析[J/OL]. 中华消化病与影像杂志(电子版), 2018, 08(01): 19-23.

Lan Zhang, Yunqin Yin. Detection of Helicobacter pylori infection by narrow-band imaging with magnification gastroscopy: a Meta analysis[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2018, 08(01): 19-23.

评价窄带成像技术(narrow-band imaging,NBI)结合显微放大胃镜对于诊断幽门螺杆菌(Helicobacter pylori,Hp)感染的价值。

方法

通过检索PubMed、Cochrane Library、EMbase、中国知网等数据库2011年1月至2016年5月有关NBI放大内镜诊断Hp感染的诊断性试验,研究文献严格根据纳入及排除标准筛选文献,对于符合纳入标准的文献提取所需相关数据,使用Meta-DiSc软件进行Meta分析。

结果

纳入文献共有6篇,包括受试患者共870例(940处病灶),NBI显微放大内镜诊断Hp感染的总灵敏度为:0.89(95% CI:0.86~0.92),总特异度为0.81(95% CI:0.77~0.85),阳性似然比为:4.90(95% CI:2.25~10.68),阴性似然比:0.11(95% CI:0.04~0.31),诊断优势比:47.55(95% CI:11.84~190.92),曲线下面积为:0.922,Q*指数为0.856。

结论

NBI结合显微放大内镜对Hp感染的诊断具有一定的价值。

Objective

To evaluate the diagnostic value of narrow-band imaging(NBI)with magnification gastroscopy in Helicobacter pylori(Hp)infection.

Methods

Literatures on NBI with magnification gastroscopy in diagnosing of Hp infection were searched in PubMed, Cochrane Library, EMBase, China National Knowledge Infrastructure and so on.According to the inclusion and exclusion criteria, the most suitable literatures were selected.The Meta-DiSc software was used to review and analyze.

Results

There were 6 studies met our inclusion, including 870 patients(940 areas). The pooled sensitivity and specificity of NBI with magnification gastroscopy in Hp infection were 0.89(95% CI: 0.86-0.92)and 0.81(95% CI: 0.77-0.85)respectively, positive 1ikelihood ratio was 4.90(95% CI: 2.25-10.68), negative likelihood ratio was 0.11(95% CI: 0.04-0.31), and the diagnostic odds ratio was 47.55(95% CI: 11.84-190.92). The area under the curve was 0.922, and Q* was 0.856.

Conclusions

The NBI with magnification gastroscopy is of definite value for the diagnosis of Hp infectione.

表1 纳入文献研究特征
表2 对纳入研究进行质量评价
图1 各组数据的阈值效应检测
图2 灵敏度与(1-特异度)对数的Spearman相关系数
图3 对各组数据进行非阈值效应检测
表3 纳入文献中所提取的用于Meta分析的数据
图4 5组数据的总灵敏度
图5 5组数据的总特异度
图6 5组数据的阳性似然比
图7 5组数据的阴性似然比
图8 经Meta分析所得出的SROC曲线
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