成年人群功能性肠病与体质量指数的相关性研究

doi:10.3877/cma.j.issn.2095-2015.2019.03.002

目的

探讨成年人群功能性肠病与体质量指数的相关性。

方法

回顾性分析2016年1月至2019年2月在宁夏回族自治区人民医院消化内科确诊的50例功能性肠病患者为病例组，同期行健康体检者50例为对照组。根据《中国成人超重和肥胖症预防控制指南》推荐的标准，以体质量指数作为不同体重分类依据，采用两独立样本t检验方法比较两者相关性。

结果

病例组与对照组比较中，年龄、性别、民族、身高、体重比较差异无统计学意义(P>0.05)，而吸烟、饮酒、睡眠情况及进食辛辣食物比较差异有统计学意义(P>0.05)；体质量指数与功能性肠病无关(P>0.05)，但女性患者功能性肠病的占比较男性多；功能性肠病患者体重过低组占比达20.0%，而健康体检人群超重/肥胖所占比例达44.0%。

结论

成年人群功能性肠病与吸烟、饮酒、睡眠情况及进食辛辣食物有关，而与年龄、性别、民族、体质量指数不存在相关性。

关键词: 功能性肠病, 体质量指数, 成年人群

Objective

To explore the correlation between functional intestinal disorders and body mass index(BMI)in adults.

Methods

A total of 50 patients with functional intestinal disorders diagnosed in Department of Gastroenterology of Ningxia Hui Autonomous Region People′s Hospital were selected as case group, and 50 healthy subjects were selected as control group.According to the criteria recommended by the Guidelines for Prevention and Control of Adults Overweight and Obesity in China, BMI was used as the basis for different body weight classifications, and two independent sample t-test method was used to compare the correlation between the two.

Results

There was no significant difference in age, gender, ethnicity, height and weight between the case group and the control group(P>0.05), but there were significant differences in smoking, drinking, sleep and eating spicy food(P<0.05). BMI was not associated with functional intestinal disorders(P>0.05), but the proportion of functional intestinal disorders in women was more than that in men.The proportion of patients with low weight was 20.0% in functional intestinal disorders patients.The proportion of overweight/obesity was 44.0% in healthy subjects.

Conclusion

Functional intestinal disorders in adults is related to smoking, drinking, sleep, and eating spicy food, but there is no correlation with age, gender, ethnicity and BMI.

Key words: Functional intestinal disorders, Body mass index, Adult population

表1 病例组与对照组一般临床资料比较

项目		病例组	对照组	P值
年龄(岁)		55.48±11.25	55.48±11.25	>0.05
性别[例(%)]		?	?	>0.05
?	男性	16(32.0)	16(32.0)	?
?	女性	34(68.0)	34(68.0)	?
民族		?	?	>0.05
?	汉族	42(84.0)	36(72.0)	?
?	回族	8(16.0)	14(28.0)	?
身高(cm)		164.54±13.18	163.72±12.58	>0.05
体重(kg)		61.74±13.18	62.54±9.67	>0.05
吸烟史[例(%)]		?	?	0.001
?	有	26(52.0)	10(20.0)	?
?	无	24(48.0)	40(80.0)	?
饮酒史[例(%)]		?	?	0.043
?	有	18(36.0)	9(18.0)	?
?	无	32(64.0)	41(82.0)	?
睡眠情况[例(%)]		?	?	0.006
?	正常	23(46.0)	10(20.0)	?
?	异常	27(54.0)	40(80.0)	?
辛辣食物[例(%)]		?	?	0.005
?	有	17(34.0)	8(16.0)	?
?	无	23(46.0)	42(84.0)	?

表1 病例组与对照组一般临床资料比较

项目		病例组	对照组	P值
年龄(岁)		55.48±11.25	55.48±11.25	>0.05
性别[例(%)]		?	?	>0.05
?	男性	16(32.0)	16(32.0)	?
?	女性	34(68.0)	34(68.0)	?
民族		?	?	>0.05
?	汉族	42(84.0)	36(72.0)	?
?	回族	8(16.0)	14(28.0)	?
身高(cm)		164.54±13.18	163.72±12.58	>0.05
体重(kg)		61.74±13.18	62.54±9.67	>0.05
吸烟史[例(%)]		?	?	0.001
?	有	26(52.0)	10(20.0)	?
?	无	24(48.0)	40(80.0)	?
饮酒史[例(%)]		?	?	0.043
?	有	18(36.0)	9(18.0)	?
?	无	32(64.0)	41(82.0)	?
睡眠情况[例(%)]		?	?	0.006
?	正常	23(46.0)	10(20.0)	?
?	异常	27(54.0)	40(80.0)	?
辛辣食物[例(%)]		?	?	0.005
?	有	17(34.0)	8(16.0)	?
?	无	23(46.0)	42(84.0)	?

表2 功能性肠病与体质量指数的相关性分析[例(%)]

体质量指数	病例组	对照组
过低组	10(20.0)	4(8.0)
正常组	26(52.0)	24(48.0)
超重组	7(14.0)	17(34.0)
肥胖组	7(14.0)	5(10.0)

表2 功能性肠病与体质量指数的相关性分析[例(%)]

体质量指数	病例组	对照组
过低组	10(20.0)	4(8.0)
正常组	26(52.0)	24(48.0)
超重组	7(14.0)	17(34.0)
肥胖组	7(14.0)	5(10.0)

1	Camilleri M. Guanylate cyclase C agonists: emerging gastrointestinal therapies and actions[J]. Gastroenterology, 2015, 148(3): 483-487.
2	Heidelbaugh JJ, Stelwagon M, Miller SA, et al.The spectrum of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: US survey assessing symptoms, care seeking, and disease burden[J]. Am J Gastroenterol, 2015, 110(4): 580-587.
3	Molodecky NA, Soon IS, Rabi DM, et al.Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review[J]. Gastroenterology, 2012, 142(1): 46-54.
4	Shailubhai K, Comiskey S, Foss JA, et al.Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses[J]. Dig Dis Sci, 2013, 58(9): 2580-2586.
5	Agostini A, Ballotta D, Righi S, et al.Stress and brain functional changes in patients with Crohn′s disease: A functional magnetic resonance imaging study[J]. Neurogastroenterol Motil, 2017, 29(10): 1-10.
6	van Oijen MG, Josemanders DF, Laheij RJ, et al.Gastrointestinal disorders and symptoms: does body mass index matter？[J]. Neth J Med, 2006, 64(2): 45-49.
7	Sadik R, Björnsson E, Simrén M. The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome [J]. Eur J Gastroenterol Hepatol, 2010, 22(1): 102-108.
8	Compare D, Coccoli P, Rocca A, et al.Gut-liver axis: the impact of gut microbiota on non alcoholic fatty liver disease [J]. Nur Metab Cardiovasc Dis, 2012, 22(6): 471-476.
9	中华人民共和国卫生部疾病预防控制司．中国成人超重和肥胖症预防控制指南[M]．北京：人民卫生出版社，2006：1-36.
10	Fang YJ, Liou JM, Chen CC, et al.Distinct aetiopathogenesis in subgrou ps of functional dyspepsia according to the Rome III criteria[J]. Gut 2015, 64(10): 1517-1528.
11	Mukhtar K, Nawaz H. Functional gastrointestinal disorders and gut-brain axis: What does the future hold？[J]. World J Gastroenterol, 2019, 25(5): 552-566.
12	Jones MP, Tack J, Van Oudenhove L, et al.Mood and Anxiety Disorders Precede Development of Functional Gastrointestinal Disorders in Patients but Not in the Population[J]. Clin Gastroenterol Hepatol, 2017, 15(7): 1014-1020.
13	Saffouri GB, Shields-Cutler RR, Chen J, et al.Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders[J]. Nature communications, 2019, 10(1): 2012.
14	Piche T. Tight junctions and IBS-the link between epithelial permeability, low-grade inflammation, and symptom generation[J]. Neurogastroenterol Motil, 2014, 26(3): 296.
15	Fritscherravens A, Schuppan D, Ellrichmann M, et al.Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome[J]. Gastroenterology, 2014, 147(5): 1012.
16	Farmer AD, Aziz Q. Gut pain&visceral hypersensitivity[J]. Br J Pain, 2013, 7(1): 39-47.
17	Cozma-Petruţ A, Loghin F, Miere D. Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients！[J]. World J Gastroenterol, 2017, 23(21): 3771-3783.
18	Camilleri M. Dietary and pharmacological treatment of abdominal pain in IBS[J]. Gut, 2017, 66(5): 966-974.
19	Camilleri M. Management Options for Irritable Bowel Syndrome[J]. Mayo Clinic Proceedings, 2018, 93(12): 1858-1872.
20	Weaver KR, Melkus GD, Henderson WA.Irritable Bowel Syndrome[J]. Am J Nurs, 2017, 117(6): 48-55.
21	Varghese MJ, Sharma G, Shukla G, et al.Longitudinal ventricular systolic dysfunction in patients with very severe obstructive sleep apnea: A case control study using speckle tracking imaging[J]. Indian Heart J, 2017, 69(3): 305-310.
22	Cesare MD, Bentham J, Stevens GA, et al.Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population based measurement studies with 19.2 million participants[J]. Lancet, 2016, 387(10026): 1377-1396.

[1]	刘云楠, 赵联璧, 侯娜, 赵美玲, 张琳, 袁丽君. 孕前超重及肥胖女性孕中期子宫-胎盘血流动力学的变化[J]. 中华医学超声杂志（电子版）, 2021, 18(12): 1180-1184.
[2]	甘玉云, 李伦兰, 汪璐璐, 代极静, 林媛媛, 刘静. 身体质量指数对全膝关节置换患者膝关节功能的影响[J]. 中华关节外科杂志(电子版), 2019, 13(05): 575-583.
[3]	魏佳文, 徐爱群. 肥胖症对孕产妇分娩镇痛及麻醉的影响[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(03): 249-254.
[4]	叶樱琳, 郭晓蒙, 郑燕伟, 蒋荣珍. 肥胖孕妇分娩新生儿的体脂率及其影响因素[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 536-544.
[5]	陈秋和, 单丹, 陈倩, 胡雅毅. 妊娠期糖尿病高龄孕妇并发子痫前期的相关因素分析[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(05): 574-583.
[6]	宋钰, 赵阳, 王惠君, 廖新华. 术前BMI与可切除胃癌患者术后远期生存的关系[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 530-533.
[7]	姜福全, 孙培鸣, 闫洪峰, 孙晓敏, 杨建武, 董满库, 杨鹤鸣, 李成林, 崔彦. 结直肠癌根治术患者不同体重与手术结局关系的回顾性研究[J]. 中华普外科手术学杂志(电子版), 2021, 15(03): 290-293.
[8]	张泽华, 杨诗怡, 熊茂明, 张嘉炜. 腹盆腔脂肪与肌肉含量与Miles术后发生造口旁疝风险的相关性研究[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(01): 9-14.
[9]	田佳鑫, 曹凯, 石砚, 辛晨, 杜蓉, 于静, 桑景荭, 王宁利. 原发性开角型青光眼全身危险因素及眼体同治的系统回顾和Meta分析[J]. 中华眼科医学杂志(电子版), 2019, 09(05): 281-291.
[10]	马庆华, 黄平, 唐育红, 劳雅琴. 苏州市某区孕妇血清25-羟维生素D水平及影响因素分析[J]. 中华临床医师杂志(电子版), 2021, 15(03): 191-193.
[11]	王慧卿, 李银玉, 张继敏, 黄正丽, 孙喜明, 薛少青, 焦爱富, 赵慧媛, 尉杰忠. 血清adipsin及皮下脂肪面积与早期糖尿病肾病的相关性分析[J]. 中华肥胖与代谢病电子杂志, 2022, 08(04): 256-262.
[12]	郑汝群, 陈小燕, 李标达, 黄才浩, 鲁可, 陈珠妮, 叶润杰, 谭雅丹, 高子晴, 颜建华. 不同BMI患者内脏脂肪差异性分析[J]. 中华肥胖与代谢病电子杂志, 2020, 06(04): 237-242.
[13]	张博锋, 孟春想, 曹凤霞. 体质量指数对老年卒中患者康复进程影响的相关性研究[J]. 中华肥胖与代谢病电子杂志, 2020, 06(03): 175-179.
[14]	吴博华, 魏水生, 李运娟, 殷诗丽. 经皮冠状动脉介入治疗后体质量指数对患者远期预后的影响[J]. 中华肥胖与代谢病电子杂志, 2020, 06(03): 170-174.
[15]	陈永光, 黄家喜, 马孟杰, 莫旭凯, 林铭霞, 梁建业, 张冬, 史长征. IDEAL-IQ序列对不同程度肥胖患者内脏脂肪的定量研究[J]. 中华肥胖与代谢病电子杂志, 2020, 06(01): 10-15.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Correlation between functional bowel disease and body mass index in adults

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Correlation between functional bowel disease and body mass index in adults