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中华消化病与影像杂志(电子版) ›› 2022, Vol. 12 ›› Issue (03) : 142 -145. doi: 10.3877/cma.j.issn.2095-2015.2022.03.004

论著

产后精神病患者大脑分数低频振幅的静息态fMRI研究
张书芬1, 柴丽萍1, 李勃2,(), 巩庆雷2, 王青磊2, 陈春莲3   
  1. 1. 250022 济南,山东省第二人民医院产科
    2. 250031 济南,中国人民解放军联勤保障部队第九六〇医院放射诊断科
    3. 250031 济南,锦州医科大学中国人民解放军联勤保障部队第九六〇医院研究生培养基地
  • 收稿日期:2021-11-03 出版日期:2022-06-01
  • 通信作者: 李勃
  • 基金资助:
    山东省医药卫生科技计划项目(202105020733); 济南市科技计划项目(202019112;202019022); 日喀则市科技项目(RKZ2020KJ06); 中国人民解放军联勤保障部队第九六〇医院院长基金项目(2021MS04)

Study of fractional amplitude of low-frequency fluctuation of resting-state fmri in postpartum psychosis

Shufen Zhang1, Liping Chai1, Bo Li2,(), Qinglei Gong2, Qinglei Wang2, Chunlian Chen3   

  1. 1. Department of Obstetrics, Shandong Second Provincial General Hospital, Jinan 250022, China
    2. Department of Radiology, the 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China
    3. The Graduate Training Base of 960th Hospital of PLA Joint Logistic Support Force of Jinzhou Medical University, Jinan 250031, China
  • Received:2021-11-03 Published:2022-06-01
  • Corresponding author: Bo Li
引用本文:

张书芬, 柴丽萍, 李勃, 巩庆雷, 王青磊, 陈春莲. 产后精神病患者大脑分数低频振幅的静息态fMRI研究[J]. 中华消化病与影像杂志(电子版), 2022, 12(03): 142-145.

Shufen Zhang, Liping Chai, Bo Li, Qinglei Gong, Qinglei Wang, Chunlian Chen. Study of fractional amplitude of low-frequency fluctuation of resting-state fmri in postpartum psychosis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(03): 142-145.

目的

探讨静息态下产后精神病患者大脑分数低频振幅的变化。

方法

本研究采集中国人民解放军联勤保障部队第九六〇医院2020年1月至2021年1月12例产后精神病患者与14例在年龄、母乳喂养、生产方式、受教育程度及是否为初产妇情况与之匹配的志愿者为对照组,利用静息态功能磁共振成像(rs-fMRI)数据进行分析,比较两组受试者全脑的fALFF差异,并分析产后精神病组有显著差异的fALFF值与简明精神病评定量表评分之间的相关性。

结果

与对照组相比,产后精神病组海马旁回和扣带回fALLF值显著升高(单个体素P<0.05,体素值≥55,AlphaSim校正),且均与简明精神病评定量表评分之间无相关性。

结论

产后精神病可引起边缘系统神经元异常活动,这有助于理解产后精神病患者的大脑神经功能改变特性。

Objective

To investigate the changes of fractional amplitude of low-frequency fluctuation in patients with postpartum psychosis in resting-state.

Methods

Twelve patients with postpartum psychosis and 14 volunteers matched with age, breast feeding, mode of production, education and primipara(control group)were collected in the 960th Hospital of PLA Joint Logistics Support Force from January 2020 to January 2021.Resting-state functional magnetic resonance imaging(rs-fMRI)data were used to compare fALFF differences in the whole brain of the two groups, and the correlation between fALFF value of postpartum psychosis group with significant differences and the score of the Brief Psychiatric Rating Scales(BPRS)was analyzed.

Results

fALLF values of the parahippocampal gyrus and cingulate gyrus were significantly higher in the postpartum psychosis group than those in the control group(individual voxel P<0.05, voxel value≥55, AlphaSim correction), and there was no correlation with the BPRS score.

Conclusion

Postpartum psychosis can cause aberrant neuronal activity in the limbic system, which is helpful to understand the altered nature of brain neurological function in postpartum psychosis patients.

表1 PP组与对照组人口学资料比较
图1 产后精神病组与对照组组间比较分数低频振幅图注:暖色代表产后精神病组分数低频振幅较对照组增强区域(单个体素P<0.05,体素值≥55,AlphaSim校正)
表2 PP组与对照组组间fALLF值差异有统计学意义脑区
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