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中华消化病与影像杂志(电子版) ›› 2023, Vol. 13 ›› Issue (01) : 1 -4. doi: 10.3877/cma.j.issn.2095-2015.2023.01.001

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微生态调节剂治疗非酒精性脂肪性肝病的现状和困境
朱国英1, 陈利2, 舍玲3, 白洁3, 丁永年3, 朱风尚4,()   
  1. 1. 200060 上海,同济大学附属普陀人民医院临床营养科
    2. 830011 乌鲁木齐,省部共建中亚高发病成因与防治国家重点实验室;200065 上海,同济大学附属同济医院消化科
    3. 830063 乌鲁木齐,新疆医科大学第二附属医院消化科
    4. 830011 乌鲁木齐,省部共建中亚高发病成因与防治国家重点实验室;200065 上海,同济大学附属同济医院消化科;830063 乌鲁木齐,新疆医科大学第二附属医院消化科
  • 收稿日期:2022-03-07 出版日期:2023-02-01
  • 通信作者: 朱风尚
  • 基金资助:
    省部共建中亚高发病成因与防治国家重点实验室项目(SKL-HIDCA-2021-DX9); 新疆维吾尔自治区科技厅科技援疆项目(2021E02075)

Therapeutic reality and dilemma of microecological modulators in patients with non-alcoholic fatty liver disease

Guoying Zhu1, Li Chen2, Ling She3, Jie Bai3, Yongnian Ding3, Fengshang Zhu4,()   

  1. 1. Department of Clinical Nutrition, Putuo People′s Hospital, Tongji University, Shanghai 200060, China
    2. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830011, China; Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China
    3. Department of Gastroenterology, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China
    4. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830011, China; Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China; Department of Gastroenterology, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China
  • Received:2022-03-07 Published:2023-02-01
  • Corresponding author: Fengshang Zhu
引用本文:

朱国英, 陈利, 舍玲, 白洁, 丁永年, 朱风尚. 微生态调节剂治疗非酒精性脂肪性肝病的现状和困境[J/OL]. 中华消化病与影像杂志(电子版), 2023, 13(01): 1-4.

Guoying Zhu, Li Chen, Ling She, Jie Bai, Yongnian Ding, Fengshang Zhu. Therapeutic reality and dilemma of microecological modulators in patients with non-alcoholic fatty liver disease[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(01): 1-4.

肠菌失调和代谢产物(类型、含量和比例)紊乱以及随后的代谢、免疫和炎症稳态失衡在非酒精性脂肪性肝病(NAFLD)进展中有潜在因果作用。广泛的基础和临床研究揭示了益生菌的保护作用,并导致有益微生物群及其活性代谢物分类成各种功能的微生态调节剂概念(益生菌、益生元、合生元和后生元)。本文概述了微生态调节剂对NAFLD患者的保护作用和机制,评述了其治疗NAFLD的临床现状和困境,提出了更前瞻、更高质量的临床对照研究的必要性和期待真实世界研究结果的理念。

Gut microbiota dysbiosis and metabolic disorders(type, content and proportion)and subsequent imbalance of metabolic, immune and inflammatory homeostasis have potential causal roles in the progression of non-alcoholic fatty liver disease(NAFLD). Extensive basic and clinical researches have revealed the protective effect of probiotics and led to the classification of beneficial microflora and their bioactive metabolites into the concepts of microecological modulators with various functions(probiotics, prebiotics, synbiotics and postbiotics). This review summarizes the protective effect and mechanism of microecological modulators on patients with NAFLD, reviews the clinical status and dilemma of their treatment of NAFLD, and proposes the necessity of more prospective and higher quality clinical controlled studies and the concept of expecting the results of real-world studies.

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