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中华消化病与影像杂志(电子版) ›› 2025, Vol. 15 ›› Issue (05) : 426 -430. doi: 10.3877/cma.j.issn.2095-2015.2025.05.002

论著

黄芪苡酱汤联合FOLFOX6方案对结直肠癌术后气虚热毒型患者免疫功能及生存质量的影响
张梦馨1, 王敏2, 张嘉倩1, 任梅梅3,(), 贾雪燕4   
  1. 1712000 陕西咸阳,陕西中医药大学附属医院肿瘤医院一病区
    2712000 陕西咸阳,陕西中医药大学附属医院肿瘤医院放疗病区
    3712000 陕西咸阳,陕西中医药大学第二附属医院肿瘤一科
    4712000 陕西咸阳,陕西中医药大学附属医院消化二科
  • 收稿日期:2025-04-21 出版日期:2025-10-01
  • 通信作者: 任梅梅

Effect of Huangqi Yijiang decoction combined with FOLFOX6 chemotherapy on immune function and quality of life in patients with Qi-deficiency and heat-toxin type after colorectal cancer surgery

Mengxin Zhang1, Min Wang2, Jiaqian Zhang1, Meimei Ren3,(), Xueyan Jia4   

  1. 1Department of Oncology, First Ward, Oncology Hospital, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
    2Department of Radiotherapy, Oncology Hospital, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
    3Department of Oncology, First Ward, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
    4Department of Gastroenterology, Second Ward, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
  • Received:2025-04-21 Published:2025-10-01
  • Corresponding author: Meimei Ren
  • Supported by:
    Shaanxi Key Research and Development Program(2018ZDCXL-SF-01-02-02)
引用本文:

张梦馨, 王敏, 张嘉倩, 任梅梅, 贾雪燕. 黄芪苡酱汤联合FOLFOX6方案对结直肠癌术后气虚热毒型患者免疫功能及生存质量的影响[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(05): 426-430.

Mengxin Zhang, Min Wang, Jiaqian Zhang, Meimei Ren, Xueyan Jia. Effect of Huangqi Yijiang decoction combined with FOLFOX6 chemotherapy on immune function and quality of life in patients with Qi-deficiency and heat-toxin type after colorectal cancer surgery[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(05): 426-430.

目的

探究黄芪苡酱汤联合FOLFOX6方案对结直肠癌根治手术后气虚热毒型患者免疫功能及生活质量的影响。

方法

前瞻性选取2022年9月至2024年12月陕西中医药大学附属医院收治的134例腹腔镜结直肠癌根治术后辅助化疗患者为研究对象。根据随机数字表法将其分为常规组(FOLFOX6+常规治疗)和治疗组(FOLFOX6+黄芪苡酱汤),各67例。比较两组中医证候评分和治疗前后CD4+、CD8+、癌胚抗原(CEA)、糖类抗原(CA)19-9、CA72-4水平变化及卡诺夫斯凯计分(KPS)。

结果

治疗后6个疗程后(14 d/疗程),治疗组患者的中医证候评分及血清CEA、CA199、CA724水平较常规组降低(均P<0.05);治疗组CD4+、CD4+/CD8+比值及KPS评分较常规组升高,CD8+细胞水平、恶心呕吐和腹泻的发生率及严重程度较常规组降低(均P<0.05)。

结论

黄芪苡酱汤联合FOLFOX6方案能有效改善结直肠癌术后气虚热毒型患者的免疫功能及生存质量,减少化学治疗的不良反应。

Objective

To investigate the effect of Huangqi Yijiang decoction combined with FOLFOX6 chemotherapy on immune function and quality of life in patients with Qi-deficiency and heat-toxin type after colorectal cancer surgery.

Methods

A total of 134 patients who underwent laparoscopic radical resection for colorectal cancer and received adjuvant chemotherapy at the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from September 2022 to December 2024 were prospectively selected as the research objects. According to the random number table method, they were divided into conventional group (FOLFOX6+conventional treatment) and treatment group (FOLFOX6+Huangqi Yijiang decoction), with 67 cases in each group. The TCM syndrome score, CD4+, CD8+, carcino-embryonic antigen (CEA), carbohydrate antigen (CA)19-9, CA72-4 levels and KPS score before and after treatment were compared between the two groups.

Results

After 6 treatment courses (14 days per course), compared with the conventional group, the TCM syndrome score and serum CEA, CA199 and CA724 levels in the treatment group were decreased (all P<0.05). Compared with the conventional group, CD4+, CD4+/CD8+ ratio and KPS score were increased, CD8+ cell level and the incidence and severity of nausea, vomiting and diarrhea were decreased in the treatment group (all P<0.05).

Conclusion

Huangqi Yijiang decoction combined with FOLFOX6 regimen can effectively improve the immune function and quality of life of patients with Qi-deficiency and heat-toxin after colorectal cancer surgery, and reduce adverse reactions of chemotherapy.

表1 两组结直肠癌患者一般资料比较
表2 两组结直肠癌患者中医证候评分比较[分,M( Q1,Q3)]
表3 两组结直肠癌患者T淋巴细胞亚群比较(±s
表4 两组结直肠癌患者肿瘤标志物比较(±s
表5 两组结直肠癌患者KPS评分比较(±s
表6 两组结直肠癌患者化学治疗后常见不良反应事件评价标准分级比较[例(%)]
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