切换至 "中华医学电子期刊资源库"

中华消化病与影像杂志(电子版) ›› 2017, Vol. 07 ›› Issue (02) : 53 -56. doi: 10.3877/cma.j.issn.2095-2015.2017.02.002

所属专题: 文献

临床研究

胰腺脂肪浸润相关临床因素分析
李娅1, 宋锐锋1, 郝玮玮1, 赵艳萍1, 徐峰1,()   
  1. 1. 450052 郑州大学第一附属医院消化内科
  • 收稿日期:2016-06-25 出版日期:2017-04-01
  • 通信作者: 徐峰

Analysis of clinical implications about fatty pancreas

Ya Li1, Ruifeng Song1, Weiwei Hao1, Yanping Zhao1, Feng Xu1,()   

  1. 1. Department of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2016-06-25 Published:2017-04-01
  • Corresponding author: Feng Xu
  • About author:
    Corresponding author: Xu Feng, Email:
引用本文:

李娅, 宋锐锋, 郝玮玮, 赵艳萍, 徐峰. 胰腺脂肪浸润相关临床因素分析[J/OL]. 中华消化病与影像杂志(电子版), 2017, 07(02): 53-56.

Ya Li, Ruifeng Song, Weiwei Hao, Yanping Zhao, Feng Xu. Analysis of clinical implications about fatty pancreas[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(02): 53-56.

目的

探讨与胰腺脂肪浸润相关的临床因素。

方法

选择2013年5月至2014年12月郑州大学第一附属医院体检中心行体检者750人,根据超声检查有无胰腺脂肪浸润分为阳性组及对照组进行回顾性研究。比较2组间各项临床指标有无差异,并使用Logistic回归分析各项指标与胰腺脂肪浸润的关系。

结果

胰腺脂肪浸润发病率约为19.6%;2组之间在年龄、是否肥胖、伴有高脂血症、高血压、非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)、高血糖等方面差异均有统计学意义(P<0.05)。经多因素Logistic回归分析,年龄大于60岁(OR=2.026,P=0.012)、肥胖(OR=1.732,P=0.031)、NAFLD(OR=2.611,P=0.007)是胰腺脂肪浸润的独立危险因素。

结论

胰腺脂肪浸润在普通人群中发病率较高,年龄大于60岁、肥胖及NAFLD是影响胰腺脂肪浸润的重要相关因素。

Objective

To investigate the clinical implications of fatty pancreas.

Methods

A total of 750 subjects who received a healthy checkup at Physical Examination Center of First Affiliated Hospital of Zhengzhou University were selected.Each subject had undergone abdominal sonography to diagnose fatty pancreas.Positive group and control group were divided with or without fatty pancreas.Clinical parameters were compared between the two groups, and their associations with fatty pancreas were examined by Logistic regression analysis.

Results

The incidence of fatty pancreas was 19.6%.Age, obesity, hypercholesterolemia, hypertension, non-alcoholic fatty liver disease(NAFLD)and hyperglycaemia were statistically different between the two groups(P<0.05). In the multivariate Logistic regression analysis, age older than 60 years(OR=2.026, P=0.012), obesity(OR=1.732, P=0.031)and NAFLD(OR=2.611, P=0.007)were independently associated with fatty pancreas.

Conclusion

The prevalence of fatty pancreas is high in the general population.Age older than 60 years, obesity and NAFLD are important associated factors of fatty pancreas.

表1 2组有无胰腺脂肪浸润研究对象的临床资料对比[例(%)]
表2 多因素Logistic回归分析胰腺脂肪浸润的相关因素
1
Goossens GH.The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance[J]. Physiol Behav, 2008, 94(2): 206-218.
2
Sepe PS, Ohri A, Sanaka S, et al.A prospective evaluation of fatty pancreas by using EUS[J]. Gastrointest Endosc, 2011, 73(5): 987-993.
3
Lee JS, Kim SH, Jun DW, et al.Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome[J]. World J Gastroenterol, 2009, 15(15): 1869-1875.
4
Hannukainen JC, Borra R, Linderbo rg K, et al.Liver and pancreatic fat content and metabol ism in healthy monozygotic twins with discordant physical activity[J]. J Hepatol, 2011, 54(3): 545-552.
5
Van Geenen EJ, Smits MM, Schreu der TC, et al.Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease[J]. Pancreas, 2010, 39(8): 1185-1190.
6
Al-Haddad M, Khashab M, Zyromski N, et al.Risk factors for hyperechog enic pancreas on endoscopic ultrasound: a case-control study[J]. Pancreas, 2009, 38(6): 672-675.
7
Yang DM, Kim HC, Ryu JK, et al.Sonographic appearance of focaI fatty infiItration of the pancreas[J]. J CIin UItrasound, 20l0, 38(1): 45-47.
8
Van der Zijl NJ, Goossens GH, Moors CC, et al.Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism[J]. J Clin Endocrinol Metab, 2011, 96(2): 459-467.
9
Ogilvie RF.The islands of Langerhans in 19 cases of obesity[J]. J Pathol Bacteriol, 1933, 37(3): 473-481.
10
Marks WM, Filly RA, Callen PW.Ultrasonic evaluation of normal pancreatic echogenicity and its relationship to fat deposition[J]. Radiology, 1980, 137(2): 475-479.
11
Schwenzer NF, Machann J, Martirosian P, et al.Quantification of pancreatic lopomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectralspatial excitation techniques[J]. Invest Radiol, 2008, 43(5): 330-337.
12
Choi CW, Kim GH, Kang DH, et al.Associated factors for a hyperechogenic pancreas on endoscopic ultra sound[J]. World J Gastroenterol, 2010, 16(34): 4329-4334.
13
Mathur A, Marine M, Lu D, et al.Nonalcoholic fatty pancreas disease[J]. HPB(Oxford), 2007, 9(4): 312-318.
14
Pitt HA.Hepato-pancreato-biliary fat: the good, the bad and the ugly[J]. HPB(Oxford), 2007, 9(2): 92-97.
15
Heni M, Machann J, Staiger H, et al.Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study[J]. Diabetes Metab Res Rev, 2010, 26(3): 200-205.
16
Noronha M, Salgadinho A, Ferreira De Almeida MJ, et al.Alcohol and the pancreas.I.Clinical associations and histopathology of minimal pancreatic inflammation[J]. Am J Gastroenterol, 1981, 76(2): 114-119.
17
Glaser J, Stienecker K. Pancreas and aging: a study using ultrasonography[J]. Gerontology, 2000, 46(2): 93-96.
18
Saisho Y, Butler AE, Meier JJ, et al.Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes[J]. Clin Anat, 2007, 20(8): 933-942.
19
Maggio AB, Mueller P, Wacker J, et al.Increased pancreatic fat fraction is present in obese adolescents with metabolic syndrome[J]. J Pediatr Gastroenterol Nutr, 2012, 54(6): 720-726.
20
Wang CY, Ou HY, Chen MF, et al.Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population[J]. J Am Heart Assoc, 2014, 3: e00029.
[1] 何甘霖, 陈香侬, 李萍, 甄佳怡, 李京霞, 邹外一, 许多荣. 白血病异基因造血干细胞移植术后股骨坏死的影响因素[J/OL]. 中华关节外科杂志(电子版), 2024, 18(04): 450-456.
[2] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[3] 陈嘉婷, 杜美君, 石冰, 黄汉尧. 母体系统性疾病对新生儿唇腭裂发生的影响[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 262-268.
[4] 吉顺富, 汤晓燕, 徐进. 腹腔镜近端胃癌根治术中拓展胃后间隙在肥胖患者中的应用研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 393-396.
[5] 杨波, 胡旭, 何金艳, 谢铭. 腹腔镜袖状胃切除术管胃固定研究现状[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 452-455.
[6] 刘盾, 潘晟. 不同入路腹腔镜袖状胃切除术用于肥胖症合并2型糖尿病的效果[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 150-154.
[7] 颜帅, 胡旭, 苟晓梅, 谢铭. 腹腔镜胃袖状切除术后并发症处置策略[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 220-224.
[8] 玉素江·图荪托合提, 韩琦, 麦麦提艾力·麦麦提明, 黄旭东, 王浩, 克力木·阿不都热依木, 艾克拜尔·艾力. 腹腔镜袖状胃切除或联合食管裂孔疝修补术对肥胖症合并胃食管反流病的中期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 501-506.
[9] 刘见, 杨晓波, 何均健, 等. 应用电钩三孔法腹腔镜袖状胃切除术[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(06): 363-364.
[10] 赵月, 田坤, 张宗明, 郭震天, 刘立民, 张翀, 刘卓. 降钙素原对老年急性重度胆囊炎发生的预测价值[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 801-806.
[11] 中国医师协会外科医师分会肥胖代谢病综合管理与护理专家工作组, 中国医师协会外科医师分会肥胖和代谢病外科专家工作组, 中国肥胖代谢外科研究协作组. 肥胖代谢外科医学科普中国专家共识(2024 版)[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(04): 227-234.
[12] 中国医师协会外科医师分会肥胖和代谢病外科专家工作组, 中国医师协会外科医师分会胃食管反流疾病诊疗外科专家工作组, 日本肥胖治疗学会, 韩国减重与代谢外科学会. 袖状胃切除术患者胃食管反流病诊治专家共识(2024版)[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 145-162.
[13] 颜宥彤, 赵锐, 万谦益, 张贵祥, 沈弘毅, 程中, 陈亿. GLP-1受体激动剂——司美格鲁肽的应用及安全性[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(02): 88-93.
[14] 崔磊, 徐东升. 减重手术治疗肥胖患者胰岛素抵抗的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(02): 127-132.
[15] 邢颖, 闫文貌. 单孔腹腔镜袖状胃切除术发展现状[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(02): 133-137.
阅读次数
全文


摘要