切换至 "中华医学电子期刊资源库"

中华消化病与影像杂志(电子版) ›› 2018, Vol. 08 ›› Issue (02) : 71 -75. doi: 10.3877/cma.j.issn.2095-2015.2018.02.006

所属专题: 文献

综述

干细胞治疗炎症性肠病的安全性及有效性
王秀1, 王义国2,()   
  1. 1. 271016 山东泰安,泰山医学院
    2. 250014 济南,山东省千佛山医院消化内科
  • 收稿日期:2017-09-20 出版日期:2018-04-01
  • 通信作者: 王义国
  • 基金资助:
    济南市科技发展计划(201401097)

Safety and efficacy of stem cell therapy for inflammatory bowel disease

Xiu Wang1, Yiguo Wang2,()   

  1. 1. Taishan Medical University, Taian 271016, China
    2. Department of Gastroenterology, Qianfoshan Hospital of Shandong Province, Jinan 250014, China
  • Received:2017-09-20 Published:2018-04-01
  • Corresponding author: Yiguo Wang
  • About author:
    Corresponding author: Wang Yiguo, Email:
引用本文:

王秀, 王义国. 干细胞治疗炎症性肠病的安全性及有效性[J/OL]. 中华消化病与影像杂志(电子版), 2018, 08(02): 71-75.

Xiu Wang, Yiguo Wang. Safety and efficacy of stem cell therapy for inflammatory bowel disease[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2018, 08(02): 71-75.

炎症性肠病(inflammatory bowel disease,IBD)是一组以复杂的病因和病理生理学改变为基础的疾病,涉及肠道微生物的改变、异常免疫反应、肠上皮细胞和血管系统提供的重要屏障的破坏,并且是一种难以治愈的疾病。药物治疗及手术切除等传统治疗方式存在明显的不足。近年干细胞因其生物学特性开辟了治疗IBD的新型方法。本文就传统方式治疗IBD的不足进行概括,并对干细胞尤其是间充质干细胞移植治疗IBD的安全性、有效性文献进行了回顾总结。

Inflammatory bowel disease(IBD)is a group of diseases on the basis of complex etiology and pathophysiology changes involving the changes of intestinal microflora, abnormal immune response, damage of important barrier offered by intestinal epithelial cells and vascular system, and is a kind of incurable disease.There are obvious deficiencies in traditional treatment, such as drug treatment and surgical excision.In recent years, stem cells have opened up a new method for the treatment of IBD because of their biological characteristics.This review summarizes the shortcomings of traditional treatment for IBD, and analyzes the safety and efficacy that stem cells transplantation treats IBD, especially mesenchymal stem cells.

1
Nagaishi K, Arimura Y, Fujimiya M. Stem cell therapy for inflammatory bowel disease[J]. J Gastroenterol, 2015, 50(3): 280-286.
2
Flores AI, Gómez-Gómez GJ, Masedo-Gonzálezá, e al.Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?[J]. World J Stem Cells, 2015, 7(2): 343-351.
3
Duran NE, Hommes DW.Stem cell-based therapies in inflammatory bowel disease: promises and pitfalls[J]. Ther Adv Gastroenterol, 2016, 9(4)533-547.
4
Dave M, Papadakis KA, Faubion WA Jr.Immunology of inflammatory bowel disease and molecular targets for biologics[J]. Gastroenterol Clin North Am, 2014, 43(3): 405-424.
5
Hommes D, Colombel JF, Emery P, et al.Changing Crohn′s disease management: Need for new goals and indices to prevent disability and improve quality of life [J]. Am J Gastroenterol, 2010, 105(2): 289-297.
6
Billioud V, Ford AC, Tedesco ED, et al.Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: A meta analysis[J]. Crohns Colitis, 2013, 7(11): 853-867.
7
Dalal J, Gandy K, Domen J. Role of mesenchymal stem cell therapy in Crohn′s disease[J]. Pediatr Res, 2012, 71(4 Pt 2): 445-451.
8
Panaccione R, Ghosh S, Middleton S, et al.Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis[J]. Gastroenterology, 2014, 146(2): 392-400.e3.
9
Thomas A, Lodhia N. Advanced therapy for inflammatory bowel disease: a guide for the primary care physician[J]. J Am Board Fam Med, 2014, 27(3): 411-420.
10
Peyrin-Biroulet L, Loftus EVJ, Colombel JF, Sandborn WJ.The natural history of adult Crohn′s disease in population-based cohorts[J]. Am J Gastroenterol, 2010, 105(2): 289-297.
11
D′Haens G, Baert F, van Assche G et al.Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn′s disease: An open randomised trial[J]. Lancet, 2008, 371(9613): 660-667.
12
Burisch J, Jess T, Martinato M, Lakatos PL.ECCO-EpiCom: The burden of inflammatory bowel disease in Europe[J]. J Crohns Colitis, 2013, 7(4): 322-337.
13
Bernstein CN, Loftus EV Jr, Ng SC, et al.Epidemiology and Natural History Task Force of the International Organization for the Study of Inflammatory Bowel Disease(IOIBD): Hospitalisations and surgery in Crohn′s disease[J]. Gut, 2012, 61(4): 622-629.
14
Chatu S, Saxena S, Subramanian V, et al.The impact of timing and duration of thiopurine treatment on first intestinal resection in Crohn′s disease: national UK population-based study 1989-2010[J]. Am J Gastroenterol, 2014, 109(3): 409-416.
15
Zand A, Van Deen W, Inserra E, et al.Presenteeism in inflammatory bowel diseases: a hidden problem with significant economic impact[J]. Inflamm Bowel Dis, 2015, 21(7): 1623-1630.
16
Armstrong L, Lako M, Buckley N, et al.Editorial: our top 10 developments in stem cell biology over the last 30 years[J]. Stem Cells, 2012, 30(1): 2-9.
17
Shroff G. Human Embryonic Stem Cell Therapy in Crohn′s Disease: A Case Report[J]. Am J Case Rep, 2016, 17(2): 124-128.
18
Okamoto R, Watanabe M. Investigating cell therapy for inflammatory bowel disease[J]. Expert Opin Biol Ther, 2016, 16(8): 1015-1023.
19
Hawkey CJ.Stem cells as treatment in inflammatory bowel disease[J]. Dig Dis, 2012;30(suppl 3): 134-139.
20
Shaker A, Rubin DC.Stem cells: One step closer to gut repair[J]. Nature, 2012, 485(7397): 181-182.
21
Tyndall A, Gratwohl A. Adult stem cell transplantation in autoimmune disease[J]. Curr Opin Hematol, 2009, 16(4): 285-291.
22
Caplan AI, Dennis JE.Mesenchymal Stem Cells as Trophic Mediators[J]. J Cell Biochem, 2006, 98(5): 1076-1084.
23
Caplan AI.Why are MSCs therapeutic? New data: new insight[J]. J Pathol, 2009, 217(2): 318-324.
24
Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system[J]. Nat Rev Immunol, 2012, 12(5): 383-396.
25
Raffaghello L, Bianchi G, Bertolotto M, et al.Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche[J]. Stem Cells, 2008, 26(1): 151-162.
26
Benvenuto F, Ferrari S, Gerdoni E, et al.Human mesenchymal stem cells promote survival of T cells in a quiescent state[J]. Stem Cells, 2007, 25(7): 1753-1760.
27
汪维伟,徐艳华,姜蓉,等.骨髓间充质干细胞移植治疗大鼠溃疡性结肠炎[J].中国组织工程研究,2012,16(32): 6030-6036.
28
Manieri NA, Mack MR, Himmelrich MD, et al.Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis[J]. J Clin Invest, 2015, 125(9): 3606-3618.
29
Ciccocioppo R, Bernardo ME, Sgarella A, et al.Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn′s disease[J]. Gut, 2011, 60(6): 788-798.
30
Grégoire C, Lechanteur C, Briquet A, et al.Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases[J]. Aliment Pharmacol Ther, 2017, 45(2): 205-221.
31
杨波,赵振林,樊强.自体骨髓间充质干细胞治疗溃疡性结肠炎疗效分析[J].临床医药实践,2015,24(7): 493-497.
32
Duijvestein M, Vos ACW, Roelofs H, et al.Autologous bone marrowderived mesenchymal stromal cell treatment for refractory luminal Crohn′s disease: results of a phase I study[J]. Gut, 2010, 59(12): 1662-1669.
33
Forbes GM, Sturm MJ, Leong RW, et al.A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn′s disease refractory to biologic therapy[J]. Clin Gastroenterol Hepatol, 2014 12(1): 64-71.
34
Algeri M, Conforti A, Pitisci A, et al.Mesenchymal stromal cells and chronic inflammatory bowel disease[J]. Immunol Lett, 2015, 168(2): 191-200.
35
Lalu MM, McIntyre L, Pugliese C, et al.Safety of cell therapy with mesenchymal stromal cells(SafeCell): a systematic review and meta-analysis of clinical trials[J]. PLoS One, 2012, 7(10): e47559.
36
Guadalajara H, Herreros D, De-La-Quintana P, et al.Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas[J]. Int J Colorectal Dis, 2012, 27(5): 595-600.
37
Hawkey CJ, Snowden JA, Lobo A, et al.Stem cell transplantation for inflammatory bowel disease: practical and ethical issues[J]. Gut, 2000, 46(6): 869-872.
38
Almeida-Porada G, Soland M, Boura J, et al.Regenerative medicine: prospects for the treatment of inflammatory bowel disease[J]. Regen Med, 2013, 8(5): 631-644.
39
Duricova D. What Can We Learn from Epidemiological Studies in Inflammatory Bowel Disease?[J]. Dig Dis, 2017 35(1/2): 69-73.
40
Munir H, McGettrick HM.Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards[J]. Stem Cells Dev, 2015, 24(18): 2091-100.
[1] 张启龙, 柳亿, 卢会丽, 罗慧, 李成林, 王菁, 王辉. 奥妥珠单抗治疗磷脂酶A2受体相关膜性肾病的疗效与安全性:单中心回顾性分析[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 379-384.
[2] 王杰, 袁泉, 王玥琦, 乔佳君, 谭春丽, 夏仲元, 刘守尧. 溃疡油在糖尿病足溃疡治疗中的应用效果及安全性观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 480-484.
[3] 蒋敏, 刘馨竹, 李大伟, 冯柏塨, 申传安. 点阵CO2激光联合其他非手术方式治疗痤疮瘢痕有效性的网状荟萃分析[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 429-439.
[4] 曹胜军, 李全, 符雪, 邵天喜, 周延华. 人脂肪间充质干细胞多层膜片对促进裸鼠皮肤缺损愈合的效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 341-347.
[5] 朴成林, 蓝炘, 司振铎, 李强, 冯健, 安峰铎, 冷建军. 胰十二指肠切除联合肝切除术疗效分析:附5例报告(附视频)[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 363-367.
[6] 王浩源, 汪海洋, 孙建明, 陈以宽, 祁小桐, 唐博. 腹腔镜与开放修补对肝硬化腹外疝患者肝功能及凝血的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 654-659.
[7] 韦雅丽, 范利杰. 术前右美托咪定滴鼻在腹股沟斜疝患儿腹腔镜下疝囊高位结扎术中的应用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 446-450.
[8] 黄建朋, 邹建强, 宗华. 肝移植术后腹壁疝诊治初步经验[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 471-473.
[9] 王鹏, 邵欣欣, 胡海涛, 田艳涛, 钟宇新. 改良MOBS 吻合法在全腹腔镜近端胃大部分切除中的应用[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 267-270.
[10] 傅红兴, 王植楷, 谢贵林, 蔡娟娟, 杨威, 严盛. 间充质干细胞促进胰岛移植效果的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 351-360.
[11] 王大伟, 陆雅斐, 皇甫少华, 陈玉婷, 陈澳, 江滨. 间充质干细胞通过调控免疫机制促进创面愈合的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 361-366.
[12] 袁园园, 岳乐淇, 张华兴, 武艳, 李全海. 间充质干细胞在呼吸系统疾病模型中肺组织分布及治疗机制的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 374-381.
[13] 王俊楠, 刘晔, 李若涵, 叶青松. 间充质干细胞调控肠脑轴治疗神经系统疾病的潜力[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 313-319.
[14] 陈利, 杨长青, 朱风尚. 重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 385-389.
[15] 陶金华, 陈珊珊, 陈晓四. 阿帕替尼联合替吉奥治疗晚期食管癌的疗效与安全性影响因素评价[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 325-329.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?