| 1 |
Goldstein JL，DeBose-Boyd RA，Brown MS.Protein sensors for membrane sterols[J]．Cell，2006，124:35-46.
|
| 2 |
Tang W，Norlin M．Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells[J]. Biochem Biophys Res Commun，2006，344(2):540-546.
|
| 3 |
Ishikawa T，Yuhanna IS，Umetani J，et al.LXRβ/estrogen receptor-αsignaling in lipid rafts preserves endothelial integrity[J]．J Clin Invest，2013，123(8):3488-3497.
|
| 4 |
DuSell CD，Michihisa U, Philip WS，et al.27-hydroxycholesterol is an endogenous selective estrogen receptor modulator[J]．Mol Endocrinol，2008，22:65-77.
|
| 5 |
Endo-Umeda K，Yasuda K，Sugita K，et al.7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase(CYP27A1)modulate liver X receptor activity[J]．J Steroid Biochem Mol Biol，2014，140:7-16.
|
| 6 |
Li T，Chen W，Chiang JY.PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine[J]. J Lipid Res，2007，48(2):373-384.
|
| 7 |
Quinn CM，Jessup W，Wong J，et al. Expression and regulation of sterol 27-hydroxylase(CYP27A1)in human macrophages：a role for RXR and PPARgamma ligands[J]. Biochem，2005，385: 823-830.
|
| 8 |
Li YC，Park MJ，Ye SK，et al.Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents[J]．Am J Pathol，2006，168(quiz 1404-1405):1107-1118.
|
| 9 |
Baek AE，Yu YA，He S，et al.The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells[J]．Nat Commun，2017，8(1):864.
|
| 10 |
Radhakrishnan A，Ikeda Y，Kwon H，et al.Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi：oxysterols block transport by binding to Insig[J]．Proc Natl，2007，104:6511-6518.
|
| 11 |
Khan NA，Stopsack KH，Allott EH，et al.Intratumoral Sterol-27-Hydroxylase(CYP27A1)Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer[J]. Cancer Epidemiol Biomarkers Prev，2019，28(6):1052-1058.
|
| 12 |
Alfaqih MA，Nelson ER，Liu W，et al.CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer[J]．Cancer Res，2017，77(7):1662-1673.
|
| 13 |
Raza S，Meyer M，Goodyear C，et al.The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβin prostate cancer cells[J]．Cancer Cell Int，2017，17:52.
|
| 14 |
Hansson M，Ellis E，Hunt MC，et al.Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages[J]．Biochim Biophys Acta，2003，1593(2/3):283-289.
|
| 15 |
Guo D，Reinitz F，Youssef M，et al.An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway[J]．Cancer Discov, 2011, 1: 442-456.
|
| 16 |
Wang Q，Ma X，Chen Y，et al.Identification of interferon-γas a new molecular target of liver X receptor[J]．Biochem J，2014，459: 345-354.
|
| 17 |
Kim SM，Lee SA，Kim BY，et al.27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production[J]. Biochem Biophys Res Commun，2013，442(3/4):159-164.
|
| 18 |
Gilligan LC，Gondal A，Tang V，et al.Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer：Implications for Hormone Replacement Therapy[J]. Front Pharmacol, 2017，8:103.
|
| 19 |
Savic D，Ramaker RC，Roberts BS，et al.Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation[J]. Genome Med，2016，8(1):74.
|
| 20 |
Uno S，Endo K，Jeong Y，et al.Suppression ofβ-catenin signaling by liver X receptor ligands[J]．Biochem Pharmacol，2009，77:186-195.
|
| 21 |
Ogola BO，Zimmerman MA，Sure VN，et al.G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress[J]. Front Endocrinol(Lausanne)，2019，10:586.
|
| 22 |
Jacenik D，Beswick EJ，Krajewska WM，et al.G protein-coupled estrogen receptor in colon function，immune regulation and carcinogenesis[J]. World J Gastroenterol，2019，25(30):4092-4104.
|
| 23 |
Pommier AJ，Alves G，Viennois E，et al.Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells[J]．Oncogene, 2010, 29: 2712-2723.
|
| 24 |
Rossin D，Dias IHK，Solej M，et al.Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage：Possible contribution to cancer cell survival and infiltration[J]. Free Radic Biol Med，2019，136:35-44.
|
| 25 |
国家消化内镜专业质控中心，国家消化系统疾病临床医学研究中心(上海)，国家消化道早癌防治中心联盟，等. 中国早期食管癌及癌前病变筛查专家共识意见(2019年，新乡)[J]. 中华健康管理学杂志，2019，13(6):465-473.
|
| 26 |
Sardana RK，Chhikara N，Tanwar B，et al.Dietary impact on esophageal cancer in humans：a review[J]. Food Funct，2018，9(4):1967-1977.
|
| 27 |
Münch NS，Fang HY，Ingermann J，et al.High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett′s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome[J]．Gastroenterology，2019，157(2):492-506.e2.
|
| 28 |
Wulaningsih W，Garmo H，Holmberg L，et al.Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS Study[J]．J Cancer Epidemiol，2012，2012:792034.
|
| 29 |
Wang Y，Li H，Diao Y，et al.Relationship between oxidized LDL antibodies and different stages of esophageal carcinoma[J]．Arch Med Res，2008，39(8):760-767.
|
| 30 |
Deng H，Zhou T，Mo X，et al.Low-density lipoprotein promotes lymphatic metastasis of esophageal squamous cell carcinoma and is an adverse prognostic factor[J]．Oncol Lett，2019，17(1):1053-1061.
|
| 31 |
Zhou C，Zhong X，Gao P，et al.Statin use and its potential therapeutic role in esophageal cancer：a systematic review and meta-analysis[J]. Cancer Manag Res，2019，11:5655-5663.
|
| 32 |
Yuan Q，Dong CD，Ge Y，et al.Proteome and phosphoproteome reveal mechanisms of action of atorvastatin against esophageal squamous cell carcinoma[J]. Aging(Albany NY)，2019，11(21):9530-9543.
|
| 33 |
Konturek PC，Burnat G，Hahn EG.Inhibition of Barret′s adenocarcinoma cell growth by simvastatin：involvement of COX-2 and apoptosis-related proteins[J]. J Physiol Pharmacol，2007，58 Suppl 3:141-148.
|
| 34 |
Ding Y，Shimada Y，Maeda M，et al.Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma.Clin Cancer Res [J]．Carroll KK.Dietary fats and cancer，1991，53(4 Suppl):1064S-1067S.
|
| 35 |
Sauer SJ，Tarpley M，Shah I，et al.Bisphenol A activates EGFR and ERK promoting proliferation，tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells[J]. Carcinogenesis，2017，38(3):252-260.
|
| 36 |
Jiang R，Yang Y，Huang Q，et al.Immunohistochemical expression of estrogen receptorα，Bcl-2 and NF-κB P65 in the polyps of patients with and without endometriosis [J]. J Obstet Gynaecol Res，2020， 10.1111/jog.14370. |
| 37 |
Zhu YH，Jeong S，Wu M，et al.Dietary Intake of Fatty Acids，Total Cholesterol，and Stomach Cancer in a Chinese Population[J]. Nutrients，2019，11(8):1730.
|
| 38 |
Eichholzer M，Stahelin HB，Gutzwiller F，et al.Association of low plasma cholesterol with mortality for cancer at various sites in men：17-y follow-up of the prospective Basel study[J]．Am J Clin Nutr，2000，71:569-574.
|
| 39 |
Lim SC，Parajuli KR，Duong HQ，et al.Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells[J]. Int J Oncol，2014，44(3):805-811.
|
| 40 |
Hong W，Guo F，Yang M，et al.Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent[J]．Lipids Health Dis，2019，18(1):203.
|
| 41 |
Fenghua Guo，Wenting Hong，Mingjie Yang，Dongke Xu，Qianming Bai，Xiaobo Li，Zongyou Chen.Upregulation of 24(R/S)，25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells[J]．Biochem BiophysRes Commun，2018，504(4):892-898.
|
| 42 |
Chang WC，Huang SF，Lee YM，et al.Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival[J]. Oncotarget，2017，8(1):692-704.
|
| 43 |
Amemiya-Kudo M，Oka J，Takeuchi Y，et al.Suppression of the pancreatic duodenal homeodomain transcription factor-1(Pdx-1)promoter by sterol regulatory element-binding protein-1c(SREBP-1c)[J]．J Biol Chem，2011，286(32):27902-27914.
|
| 44 |
Chen H，Qin S，Wang M，et al.Association between cholesterol intake and pancreatic cancer risk：evidence from a meta-analysis[J]．Sci Rep，2015，5:8243.
|
| 45 |
Candelaria NR，Addanki S，Zheng J，et al.Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells[J]．PLoS One，2014，9(9):e106289.
|
| 46 |
Dwyer JR，Sever N，Carlson M，et al.Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells[J]．J Biol Chem，2007，282(12):8959-8968.
|
| 47 |
Soncini M，Corna G，Moresco M，et al.24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development[J]．Proc Natl Acad Sci U S A，2016，113(41):E6219-E6227.
|
| 48 |
Roberg-Larsen H，Lund K，Vehus T，et al.Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[J]. J Lipid Res，2014，55(7):1531-1536.
|
| 49 |
Bieghs V，Hendrikx T，van Gorp PJ，et al.The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice[J]. Gastroenterology，2013，144(1):167-178.e1.
|
| 50 |
Li D，Long W，Huang R，et al.27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice[J]. Obesity(Silver Spring)，2018，26(4):713-722.
|
| 51 |
Ma D，Liu W，Wang Y．ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels[J]. Biochimie，2014，103:101-108.
|
| 52 |
Heverin M，Ali Z，Olin M，et al.On the regulatory importance of 27-hydroxycholesterol in mouse liver[J]. J Steroid Biochem Mol Biol，2017，169:10-21.
|