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中华消化病与影像杂志(电子版) ›› 2021, Vol. 11 ›› Issue (05) : 222 -225. doi: 10.3877/cma.j.issn.2095-2015.2021.05.009

综述

细胞自噬在肝癌进展中的作用
吴旻杭1, 曹莉莉2,()   
  1. 1. 250014 济南,山东中医药大学山东省千佛山医院肿瘤科
    2. 250014 济南,山东中医药大学山东省千佛山医院肿瘤科;250014 济南,山东第一医科大学第一附属医院(山东省千佛山医院)肿瘤科山东省风湿免疫病转化医学重点实验室
  • 收稿日期:2021-02-07 出版日期:2021-10-01
  • 通信作者: 曹莉莉
  • 基金资助:
    山东省自然科学基金(ZR2020MH203); 山东省中医药科技发展计划(2019-0378); 山东第一医科大学第一附属医院培育基金(QYPY2019NSFC1015)

Role of autophagy in the progression of liver cancer

Minhang Wu1, Lili Cao2,()   

  1. 1. Department of Oncology, Shandong Provincial Qianfoshan Hospital, Shandong Traditional Chinese Medicine University, Jinan 250014, China
    2. Department of Oncology, Shandong Provincial Qianfoshan Hospital, Shandong Traditional Chinese Medicine University, Jinan 250014, China; Department of Oncology, First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Provincial Key Laboratory for Rheumatic Immunity Disease and Translational Medicine, Jinan 250014, China
  • Received:2021-02-07 Published:2021-10-01
  • Corresponding author: Lili Cao
引用本文:

吴旻杭, 曹莉莉. 细胞自噬在肝癌进展中的作用[J]. 中华消化病与影像杂志(电子版), 2021, 11(05): 222-225.

Minhang Wu, Lili Cao. Role of autophagy in the progression of liver cancer[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2021, 11(05): 222-225.

肝癌作为一种常见的恶性肿瘤,其侵袭性和复杂的发病机制决定了后续治疗的困难程度。自噬,即细胞将自身损伤的蛋白质或细胞器降解以循环利用的过程,在细胞内环境稳态调节中发挥重要作用。目前自噬在肝癌发展中的作用机制尚不明确,研究表明某些分子或药物可以通过对自噬通路的调节,促进或抑制肝癌细胞生存。本文旨在通过对这些分子和药物的整理,总结自噬在肝癌进展中的作用,探索其为癌症诊断和治疗带来的新思路。

Liver cancer is a common malignant tumor, whose invasiveness and complex pathogenesis determine the difficulty of subsequent treatment.Autophagy, a process by which cells degrade their own damaged proteins or organelles for recycling, plays an important role in the regulation of intracellular homeostasis.At present, the mechanism of autophagy in the development of liver cancer remains unclear.Studies have shown that some molecules or drugs can promote or inhibit the survival of liver cancer cells by regulating the autophagy pathway.This review was aimed at summarizing the role of autophagy in the progression of liver cancer and exploring new ideas for cancer diagnosis and treatment by sorting out these molecules and drugs.

表1 抗肝癌治疗研究中调节自噬的药物及制剂
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