目的

分析监测帕金森病合并幽门螺杆菌（Hp）感染患者外周炎症因子、凝血功能指标特征及与患者病情的关联性，探讨Hp 对帕金森病病情进程的关系。

方法

纳入阜阳市第五人民医院2021 年3 月至2023 年3 月收治的70 例帕金森病患者作为观察组，另选取同期健康体检者50 例作为对照组，所有人进行¹³C 呼气试验检测，按照观察组Hp 感染发生情况，将患者分别纳入Hp 感染组（n=41）、非Hp 感染组（n=29），比较不同组别间的外周炎症因子[白细胞介素（IL）-1β、IL-6、IL-10、肿瘤坏死因子α（TNF-α）]、凝血功能指标[凝血酶原时间、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）和纤维蛋白原（FIB）]，同时采用Hoehn-Yahr（H-Y）分级量表、统一帕金森病评定量表（UPDRS）Ⅲ和Ⅳ评估患者病情严重程度及运动功能状况，分析Hp 感染与帕金森病外周炎症因子、凝血功能指标特征变化情况，采用Sprearman 模型分析合并Hp 感染与帕金森患者病情严重程度的相关性。

结果

观察组IL-1β、IL-6、IL-10、TNF-α、FIB 均高于对照组，TT、APTT 均低于对照组，差异有统计学意义（P＜0.05）；两组年龄、体重指数、高血压、糖尿病、饮酒史、吸烟史、¹³C 呼气试验阳性比较差异无统计学意义（P＞0.05）。Hp 感染组IL-1β、IL-6、IL-10、TNF-α、FIB 均高于非Hp 感染组，TT、APTT 均低于非Hp 感染组，差异有统计学意义（P＜0.05）；两组年龄、体重指数、高血压、糖尿病、饮酒史、吸烟史比较差异无统计学意义（P＞0.05）。Hp感染组H-Y 分级量表、UPDRS-Ⅲ、UPDRS-Ⅳ得分均高于非Hp 感染组，病情严重程度重度比例也高于非Hp 感染组，差异有统计学意义（P＜0.05）。Sprearman 分析显示，Hp 感染与帕金森患者病情严重程度呈正相关（r=0.483，P＜0.05）。

结论

帕金森病患者发生Hp 感染与患者炎症状态、凝血功能异常均存在密切关联，与帕金森病情严重程度呈现正相关。对于帕金森病患者，控制Hp 感染可能有助于改善炎性症状和疾病管理。

Objective

To analyze and monitor the characteristics of peripheral inflammatory factors and coagulation function indexes in patients with Parkinson's disease complicated with Helicobacter pylori (Hp) infection and their correlation with the disease condition, and to explore the relationship between Hp and the disease course of Parkinson's disease.

Methods

From March 2021 to March 2023, 70 Parkinson's disease patients admitted to Fuyang Fifth People's Hospital were included as the observation group, and 50 healthy individuals undergoing physical examination during the same period were selected as the control group, and all participants underwent the ¹³C urea breath test.According to the occurrence of Hp infection in the observation group, patients were divided into the Hp infection group(n=41) and the non-Hp infection group (n=29), the levels of peripheral inflammatory factors [interleukin(IL)-1β, IL-6, IL-10, tumor necrosis factor-α (TNF-α)] and coagulation function indicators [prothrombin time, thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB)] were compared between different groups, at the same time, Hoehn-Yahr (H-Y) rating scale, unified Parkinson's disease rating scale (UPDRS) Ⅲ and Ⅳ were used to evaluate the severity of the patients' disease and motor function status, and to analyze Hp infection and the changes in the characteristics of peripheral inflammatory factors and coagulation function indicators of Parkinson's disease.Sprearman model was used to analyze the correlation between Hp infection and the severity of Parkinson's disease.

Results

IL-1β,IL-6, IL-10, TNF-α and FIB in observation group were higher than those in control group, and TT and APTT were lower than those in control group, with statistically significant differences (P<0.05).There were no statistically significant differences in age, body mass index, hypertension, diabetes, drinking history, smoking history and positive ¹³C breath test between the two groups (P>0.05).IL-1β, IL-6, IL-10,TNF-α and FIB in Hp infection group were higher than those in non-Hp infection group, and TT and APTT were lower than those in non-Hp infection group, with statistically significant differences (P<0.05).There were no statistically significant differences in age, body mass index, hypertension, diabetes, drinking history and smoking history between the two groups (P>0.05).H-Y grading scale, UPDRS-Ⅲ and UPDRS-Ⅳ scores of Hp infection group were higher than those of non-Hp infection group, and the severity ratio of disease was also higher than that of non-Hp infection group, with statistical significant differences (P<0.05).Sprearman analysis showed that Hp infection was positively correlated with the severity of Parkinson's disease (r=0.483, P<0.05).

Conclusions

Hp infection in patients with Parkinson's disease is closely related to inflammatory state and coagulation dysfunction, and is positively correlated with the severity of Parkinson's disease.For people with Parkinson's disease, controlling Hp infection may help improve inflammatory symptoms and disease management.