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中华消化病与影像杂志(电子版) ›› 2025, Vol. 15 ›› Issue (05) : 444 -448. doi: 10.3877/cma.j.issn.2095-2015.2025.05.005

论著

营养风险指数、营养控制状态评分和尿素肌酐比值对胃癌患者营养和预后的评价
周厚宁1,(), 崔巧玲2, 付瑞标3   
  1. 1221100 江苏省,徐州市第一人民医院临床营养科
    2221100 江苏省,徐州市第一人民医院合作发展处
    3221100 江苏省,徐州市第一人民医院胃肠外科
  • 收稿日期:2024-10-10 出版日期:2025-10-01
  • 通信作者: 周厚宁

Evaluation of nutrition risk index, nutritional control status score and urea-creatinine ratio on nutrition and prognosis of patients with gastric cancer

Houning Zhou1,(), Qiaoling Cui2, Ruibiao Fu3   

  1. 1Department of Clinical Nutrition, Xuzhou First People's Hospital, Xuzhou 221100, China
    2Cooperative Development Division, Xuzhou First People's Hospital, Xuzhou 221100, China
    3Department of Gastrointestinal Surgery, Xuzhou First People's Hospital, Xuzhou 221100, China
  • Received:2024-10-10 Published:2025-10-01
  • Corresponding author: Houning Zhou
引用本文:

周厚宁, 崔巧玲, 付瑞标. 营养风险指数、营养控制状态评分和尿素肌酐比值对胃癌患者营养和预后的评价[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(05): 444-448.

Houning Zhou, Qiaoling Cui, Ruibiao Fu. Evaluation of nutrition risk index, nutritional control status score and urea-creatinine ratio on nutrition and prognosis of patients with gastric cancer[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(05): 444-448.

目的

分析营养风险指数(NRI)与营养控制状态(CONUT)评分及尿素肌酐比值(UCR)对胃癌患者营养状况和预后质量的评价作用。

方法

选取徐州市第一人民医院2021年1月至2023年1月收治的197例胃癌患者进行回顾性分析,使用营养风险筛查2002量表(NRS 2002)评估其营养状态,并将NRS 2002评分≥3分、<3分者分别纳入营养风险组、无营养风险组,对比2组患者NRI、CONUT、UCR差异,使用Pearson相关性分析计算NRI、CONUT、UCR与白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)等的相关性;按照患者随访1年预后,将患者分别纳入预后良好组、预后不良组,对比2组基线资料和营养状况、UCR,使用Logistic多因素回归模型归纳影响患者预后的相关因素。

结果

197例患者中,71例NRS 2002评分≥3分,营养风险组NRI评分和ALB、PA、Hb均较无营养风险组更低,其CONUT评分、UCR较无营养风险组更高(P<0.05)。Pearson相关性分析示,NRS 2002评分、CONUT评分、UCR均与ALB、PA、Hb呈负相关,NRI评分与ALB、PA、Hb呈正相关(P<0.05)。197例患者均获得有效随访,随访时间12~42个月,中位随访时间31个月。随访期间37例患者预后不良。Logistic多因素回归分析示,体重指数<18.5 kg/m2、TNM分期Ⅲ期、NRS 2002评分≥3分、CONUT评分≥3分、UCR≥20均为胃癌患者预后不良的独立风险因素,NRI评分≥99分为保护性因素(P<0.05)。

结论

NRI、CONUT、UCR均能够指导胃癌患者营养状况的评估,且上述参数结合体重指数、TNM分期有望为胃癌患者预后质量的预测提供新的思路。

Objective

To analyze the evaluation of nutritional risk index (NRI), nutritional control status score (CONUT) and urea-creatinine ratio (UCR) on nutritional status and prognosis quality of gastric cancer patients.

Methods

A total of 197 patients with gastric cancer admitted to Xuzhou First People’s Hospital from January 2021 to January 2023 were selected and retrospectively analyzed, and their nutritional status were evaluated by the Nutrition Risk Screening Scale 2002 (NRS 2002). Those with NRS 2002 scores of ≥3 and <3 were respectively included in the nutrition risk group and the non-nutrition risk group. The differences of NRI, CONUT and UCR between the two groups were compared, and the correlations between NRI, CONUT, UCR and blood albumin (ALB), prealbumin (PA), hemoglobin (Hb), etc. were calculated using Pearson correlation analysis. According to the patients' prognosis after one-year follow-up, the patients were divided into the good prognosis group and the poor prognosis group, and the baseline data, nutritional status and UCR of the two groups were compared. Logistic multivariate regression model was used to summarize the related factors affecting the prognosis of the patients.

Results

Among the 197 patients, 71 patients had NRS 2002 score ≥3. The NRI score, ALB, PA and Hb in the nutritional risk group were lower than those in the non-nutritional risk group, and their CONUT score and UCR were higher than those in the non-nutritional risk group (P<0.05). Pearson correlation analysis showed that NRS 2002 score, CONUT score and UCR were negatively correlated with ALB, PA and Hb, while NRI score was positively correlated with ALB, PA and Hb (P<0.05). All 197 patients were effectively followed up for 12 to 42 months, with a median follow-up time of 31 months. During the follow-up period, 37 patients had poor prognosis. Logistic regression analysis showed that body mass index<18.5 kg/m2, TNM stage Ⅲ, NRS 2002 score ≥3, CONUT score ≥3 and UCR≥20 were all independent risk factors for poor prognosis of patients with gastric cancer, and NRI score ≥99 was a protective factor (P<0.05).

Conclusion

NRI, CONUT and UCR can guide the evaluation of nutritional status of patients with gastric cancer, and the above parameters combined with body mass index and TNM staging are expected to provide new ideas for predicting the prognosis quality of patients with gastric cancer.

表1 胃癌患者营养风险分组各项评分和实验室指标比较(±s
表2 胃癌患者营养状态评分与营养指标的相关性分析(r值)
表3 胃癌患者预后良好与预后不良组临床资料比较[例(%)]
表4 多因素回归分析赋值表
表5 影响胃癌患者预后的多因素回归分析结果
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