探究消旋卡多曲和酪酸梭菌二联活菌散在急性轮状病毒腹泻中的疗效和安全性。

选取新疆维吾尔自治区人民医院2017年6月至2018年6月诊断及就诊的急性轮状病毒腹泻患儿100例，使用随机数表法分为对照组(50例)和观察组(50例)，对照组予以抗病毒、补液及纠正酸碱平衡等常规治疗，观察组在此基础上予以消旋卡多曲和酪酸梭菌二联活菌散治疗。比较两组治疗疗效、治疗后症状改变情况、治疗前后肿瘤坏死因子α(tumor necrosis factorα，TNF-α)、白细胞介素6(interleukin 6，IL-6)及内毒素水平及治疗期间不良反应发生情况。

观察组治疗总有效率显著高于对照组(98%比78%；χ²＝5.892，P＝0.014)。观察组腹泻时间、住院时间、发热时间、呕吐时间显著小于对照组(t＝13.875、12.438、7.348、9.382；P＝0.000、0.007、0.012、0.008)，同时需静脉补液治疗及治疗7 d后仍腹泻的人数显著少于对照组(t＝5.005、5.982；P＝0.025、0.014)。治疗后观察组外周血中TNF-α、IL-6及内毒素显著小于对照组(t＝5.619、7.838、4.169；P＝0.000、0.000、0.001)。观察组治疗不良反应发生发生率显著小于对照组(18.00%比4.00%；χ²＝5.005，P＝0.025)。

消旋卡多曲联合酪酸梭菌二联活菌散治疗急性轮状病毒腹泻的疗效显著，能有效改善症状及炎症水平，且具有较好安全性。

To explore the efficacy and safety of racecadotril and clostridium butyricum in acute rotavirus diarrhea.

From June 2017 to June 2018, 100 children with acute rotavirus diarrhea diagnosed and treated in People′s Hospital of Xinjiang Uygur Autonomous Region were selected, and all the patients were divided into control group(50 cases)and observation group(50 cases)using the random number table method.The patients in control group were given conventional treatment such as antivirus, fluid infusion and acid-base balance correction, and the patients in observation group were treated with racecadotril and clostridium butyrate on this basis.The curative effect, symptoms change after treatment, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), endotoxin level before and after treatment and adverse reactions during treatment were compared between the two groups.

The total therapeutic efficiency in observation group was significantly higher than that in control group(98% vs.78%; χ²=5.892, P=0.014). Duration of diarrhea, hospitalization, fever and vomiting in observation group were significantly less than those in the control group(t=13.875, 12.438, 7.348, 9.382; P=0.000, 0.007, 0.012, 0.008), and the patients who requiring intravenous fluid infusion and remaining diarrhea after 7 days of treatment were significantly less in observation group(t=5.005, 5.982; P=0.025, 0.014). After treatment, TNF-α, IL-6 and endotoxin in peripheral blood of observation group were significantly lower than those of control group(t=5.619, 7.838, 4.169; P=0.000, 0.000, 0.001). The incidence of adverse reactions in observation group was significantly lower than that in control group(18.00% vs.4.00%; χ²=5.005, P=0.025).

The curative effect of racecadotril and clostridium butyricum in treating acute rotavirus diarrhea is remarkable.It can effectively improves symptoms and inflammation levels, and has better safety.