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中华消化病与影像杂志(电子版)

中华消化病与影像杂志(电子版) ›› 2020, Vol. 10 ›› Issue (03) : 109 -114. doi: 10.3877/cma.j.issn.2095-2015.2020.03.004

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综述

长链非编码RNA作为一种非侵入性标志物在肝细胞癌中应用的研究进展
吕欣然1, 曹莉莉2,†()   
  1. 1. 250014　济南，山东第一医科大学第一附属医院　山东省千佛山医院肿瘤科
    2. 250014　济南，山东第一医科大学第一附属医院　山东省千佛山医院肿瘤科；250014　济南，山东大学附属千佛山医院风湿免疫病转化医学重点实验室
  • 收稿日期:2020-03-09 出版日期:2020-06-01
  • 通信作者: 曹莉莉
  • 基金资助:
    山东省重点研发计划(2019GSF108180); 山东省中医药科技发展计划(2019-0378); 济南市科技发展计划(201907119); 山东第一医科大学第一附属医院培育基金(QYPY2019NSFC1015)

Research progress of long non-coding RNA as a non-invasive marker in hepatocellular carcinoma

Xinran Lyu1, Lili Cao2,†()   

  1. 1. Department of Oncology, First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan 250014, China
    2. Department of Oncology, First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan 250014, China; Key Laboratory of Rheumatoid Immunology Translation Medicine, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China
  • Received:2020-03-09 Published:2020-06-01
  • Corresponding author: Lili Cao
  • About author:
    Corresponding author: Cao Lili, Email:
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吕欣然, 曹莉莉. 长链非编码RNA作为一种非侵入性标志物在肝细胞癌中应用的研究进展[J]. 中华消化病与影像杂志(电子版), 2020, 10(03): 109-114.

Xinran Lyu, Lili Cao. Research progress of long non-coding RNA as a non-invasive marker in hepatocellular carcinoma[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(03): 109-114.

肝细胞癌（HCC）早期症状不明显，异质性强且恶性程度极高，目前缺乏有效的诊断和治疗方法，患者预后差，临床病死率高。近年来发现长链非编码RNA（lncRNA）可作为一种新的肿瘤标志物用于HCC的诊断。存在于血浆、血清、外泌体、唾液等体液中的lncRNAs包括SNHG1、HEIH、HULC、Linc00152、ZFAS1、Uc001ncr、Ax800134、LRB1、UCA1、D16366、ENSG00000258332.1、LINC00635、LncRNA-ATB、LINC00161、LncRNA-PCDH9-13:1等。lncRNA与AFP联合应用、lncRNA相关风险评分系统和外泌体竞争性内源RNA（ceRNA）生物标志物面板可有效提高lncRNAs对HCC诊断和预测效能。

关键词: 肝细胞癌, 长链非编码RNA, 非侵入性, 生物标志物

The early symptoms of hepatocellular carcinoma (HCC) are not obvious, the heterogeneity is strong and the degree of malignancy is very high. Currently, there is a lack of effective diagnosis and treatment methods, resulting in poor prognosis and high mortality. In recent years, it has been found that long non-coding RNA (lncRNA) can be used as a new tumor marker in the diagnosis of HCC. The lncRNAs in plasma, serum, exosomes, saliva and other body fluids includ SNHG1, HEIH, HULC, Linc00152, ZFAS1, Uc001ncr, Ax800134, LRB1, UCA1, D16366, ENSG00000258332.1, LINC00635, LncRNA-ATB, LINC00161, LncRNA-PCDH9-13:1 and others. The combination of lncRNA and AFP, lncRNA-related risk scoring system and exosomal competing endogenous RNA (ceRNA) biomarker panel can effectively improve the diagnostic and predictive efficiency of lncRNAs for HCC.

Key words: Hepatocellular carcinoma, Long non-coding RNAs, Noninvasive, Biomarkers
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