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中华消化病与影像杂志(电子版) ›› 2020, Vol. 10 ›› Issue (06) : 252 -255. doi: 10.3877/cma.j.issn.2095-2015.2020.06.004

所属专题: 文献

临床研究

低剂量CT灌注成像对胃癌分化程度评估及Her2、EGFR水平相关性研究
李慧1, 征锦2,(), 叶靖2   
  1. 1. 225001 江苏扬州,扬州大学附属江苏省苏北人民医院影像科
    2. 225001 江苏扬州,江苏省苏北人民医院影像科
  • 收稿日期:2020-05-22 出版日期:2020-12-01
  • 通信作者: 征锦

Role of low-dose CT perfusion imaging in the evaluation of differentiation degree of gastric cancer and its correlation with Her2 and EGFR levels

Hui Li1, Jin Zheng2,(), Jing Ye2   

  1. 1. Department of Radiology, Jiangsu Subei People′s Hospital Affiliated to Yangzhou University, Yangzhou 225001, China
    2. Department of Radiology, Jiangsu Subei People′s Hospital, Yangzhou 225001, China
  • Received:2020-05-22 Published:2020-12-01
  • Corresponding author: Jin Zheng
引用本文:

李慧, 征锦, 叶靖. 低剂量CT灌注成像对胃癌分化程度评估及Her2、EGFR水平相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2020, 10(06): 252-255.

Hui Li, Jin Zheng, Jing Ye. Role of low-dose CT perfusion imaging in the evaluation of differentiation degree of gastric cancer and its correlation with Her2 and EGFR levels[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(06): 252-255.

目的

探讨低剂量CT灌注成像对术前胃癌分化程度评估及与Her2、EGFR表达的相关性。

方法

选取2019年8月至2020年1月江苏省苏北人民医院就诊的43例胃癌患者,术前1周行低剂量320排多层螺旋CT灌注扫描,得到灌注参数:血流量(BF)、血容量(BV)、毛细血管通透性(PS)和平均通过时间(MTT),根据术后病理结果将低分化腺癌、印戒细胞癌和黏液腺癌分A组,将中高分化腺癌分为B组。再根据免疫组化结果,EGFR表达(-)为阴性组,EGFR表达(1+、2+)为阳性组;Her2表达(0、1+)为阴性组,Her2表达(3+)为阳性组,应用SPSS 19.0软件计算。

结果

A组与B组间BF、BV、PS值有统计学差异,Her2、EGFR表达水平与各灌注参数均无明显相关性,同时,BF、PS值在EGFR表达阴性与阳性组间有统计学差异。

结论

CT灌注成像可从体外非侵入性获得肿瘤内部血流灌注情况,灌注参数BF、BV、PS值对术前评估胃癌分化程度意义较大,而Her2、EGFR表达水平与灌注参数相关性较差,可作为辅助性观察指标。

Objective

To investigate the role of low-dose CT perfusion imaging in the preoperative evaluation of differentiation degree of gastric cancer and its correlation with the expression of Her2 and EGFR in gastric cancer.

Methods

A total of 43 patients with gastric cancer were selected from August 2019 to January 2020 in Jiangsu Subei People′s Hospital.Low-dose 320-row multi-slice spiral CT perfusion scan was performed one week before surgery, and perfusion parameters were obtained, including blood flow(BF), blood volume(BV), capillary permeability(PS)and mean passage time(MTT). According to the postoperative pathological results, the poorly differentiated adenocarcinoma, signet-ring cell carcinoma and mucinous adenocarcinoma were divided into group A, and the moderately well-differentiated adenocarcinoma was divided into group B. According to the results of immunohistochemistry, EGFR expression(-)was the negative group, and EGFR expression(1+ , 2+ )was the positive group.The expression of Her2(0, 1+ )was the negative group, and the expression of Her2(3+ )was the positive group.SPSS19.0 software was used for calculation.

Results

The values of BF, BV and PS were statistically different between group A and group B, and there was no significant correlation between the expression levels of Her2 and EGFR and the perfusion parameters.Meanwhile, the values of BF and PS were statistically different between the EGFR negative and positive groups.

Conclusion

CT perfusion imaging can obtain tumor internal blood flow perfusion from non-invasive in vitro.The perfusion parameters BF, BV and PS are of great significance in preoperative evaluation of gastric cancer differentiation, while the expression levels of Her2 and EGFR are poorly correlated with the perfusion parameters, which can be used as auxiliary observation indicators.

图9、10 分别为患者1和患者2的病理图(HE×100)
表1 低分化组(A组)与高分化组(B组)胃癌CT灌注参数比较(±s)
表2 EGFR表达与灌注参数相关性分析(±s)
表3 HER2表达与灌注参数相关性分析(±s)
1
Shelley McGuire.World Cancer Report 2014.Geneva,Switzerland:World Health Organization,International Agency for Research on Cancer,WHO Press,2015[J].Adv Nutr,2016,7(2):418-419.
2
Miles KA, Hayball M, Dixon AK.Colour perfusion imaging:a new application of computed tomography[J].Lancet,1991,337(8742):643-645.
3
Miles KA.Measurement of tissue perfusion by dynamic computed tomography[J].Br J Radiol,1991,64(761):409-412.
4
Fegley MW, Spelde A, Johnson D,et al.Malperfusion During Hypothermic Antegrade Cerebral Perfusion:Cerebral Perfusion Index-An Early Indicator Compared to Cerebral Oximetry[J].J Cardiothorac Vasc Anesth,2018,32(4):1835-1837.
5
Nishine H, Muraoka H, Inoue T,et al.Pulmonary Perfusion Using Intrabronchial Capnography in Pulmonary Artery Stenosis[J].Respiration,2018,95(6):465-468.
6
Ma R, Hunter P, Cousins W,et al.Anatomically based simulation of hepatic perfusion in the human liver[J].Int J Numer Method Biomed Eng,2019,35(9):e3229.
7
Li P, Deng W, Xue H,et al.Weight-adapted ultra-low-dose pancreatic perfusion CT:radiation dose,image quality,and perfusion parameters[J].Abdom Radiol(NY),2019,44(6):2196-2204.
8
钟星,张俊祥,陈自谦,等.胃癌多层螺旋CT灌注成像研究现状与进展[J].中国医疗设备,2013,28(1):20-23.
9
Kambadakone AR, Sahani DV.Body perfusion CT:technique,clinical applications,and advances[J].Radiol Clin North Am,2009,47(1):161-178.
10
Ma SH, Le HB, Jia BH,et al.Peripheral pulmonary nodules:relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression[J].BMC Cancer,2008,8:186.
11
Kruk-Bachonko J, Krupski W, Czechowski M,et al.Perfusion CT-A novel quantitative and qualitative imaging biomarker in gastric cancer[J].Eur J Radiol,2017,95:399-408.
12
朱勇,何光武,傅燕飞,等.多层螺旋CT灌注成像对胃癌病理分化程度评估的研究[J].实用放射学杂志,2015,31(1):75-77,86.
13
孙宗琼,延根,陈林,等.CT灌注成像对胃癌评估的临床应用[J].实用放射学杂志,2016,32(8):1230-1232,1236.
14
王莉莉,徐香玖,黄刚,等.多层螺旋CT灌注成像在胃癌术前评估中的应用[J].中国医学影像学杂志,2012,(8):590-593.
15
何方龙,徐剑.VEGF-C、EGFR在胃癌组织中的表达及临床意义[J].中外医学研究,2019,17(8):73-75.
16
李禹,程爱兰.胃癌组织中CTSD、HSP90α、EGFR的表达及临床意义[J].临床与实验病理学杂志.2017,33(10):1074-1077.
17
杨雪,何滔,时丽芳,等.CXCL14和EGFR在胃癌组织中的表达及其临床意义[J].中国肿瘤临床,2016,(19):860-864.
18
刘洋,高剑波,岳松伟,等.CT强化率、灌注参数与胃癌病灶中HER2表达的关系[J].世界华人消化杂志,2015,23(3):426-431.
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