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中华消化病与影像杂志(电子版) ›› 2020, Vol. 10 ›› Issue (06) : 267 -271. doi: 10.3877/cma.j.issn.2095-2015.2020.06.007

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综述

非酒精性脂肪性肝炎相关肝细胞癌特征及诊治进展
陈利1, 朱风尚1,(), 杨长青1   
  1. 1. 200065 上海,同济大学附属同济医院消化科
  • 收稿日期:2020-05-28 出版日期:2020-12-01
  • 通信作者: 朱风尚
  • 基金资助:
    上海市临床重点专科建设项目基金(shslczdzk06801)

Characteristics and diagnosis and treatment progress of nonalcoholic steatohepatitis-related hepatocellular carcinoma

Li Chen1, Fengshang Zhu1,(), Changqing Yang1   

  1. 1. Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China
  • Received:2020-05-28 Published:2020-12-01
  • Corresponding author: Fengshang Zhu
引用本文:

陈利, 朱风尚, 杨长青. 非酒精性脂肪性肝炎相关肝细胞癌特征及诊治进展[J/OL]. 中华消化病与影像杂志(电子版), 2020, 10(06): 267-271.

Li Chen, Fengshang Zhu, Changqing Yang. Characteristics and diagnosis and treatment progress of nonalcoholic steatohepatitis-related hepatocellular carcinoma[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(06): 267-271.

随着非酒精性脂肪性肝病(NAFLD)成为全球第一大慢性肝病后,非酒精性脂肪性肝炎相关肝癌(NASH-HCC)患者逐年增加,并渐成为肝癌最普遍病因。与其他病因肝癌明显不同,NASH-HCC与遗传因素、代谢综合征、肠道菌群改变和持续炎症等危险因素有关,临床上NASH-HCC多发生于年龄较大、男性、肥胖患者,并可由无肝硬化的NAFLD发展而来,在超声、CT及MRI检查中各有其相对特征性的表现。本文就NASH-HCC特征及诊治进展进行综述。

Considering that nonalcoholic fatty liver disease(NAFLD)has become the world′s first chronic liver disease, patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma(NASH-HCC)have increased dramatically, and it has leapt to the most common cause of liver cancer.Unlike other causes of liver cancer, NASH-HCC is strongly associated with the cluster of risk factors including genetic factors, metabolic syndrome, gut microbiota and chronic persistent inflammation.Clinically, NASH-HCC mostly occurs in aging, male, obese patients, and can evolve from NAFLD without cirrhosis.The relatively characteristic manifestations of NASH-HCC in ultrasound, CT and MRI examinations are significantly different from other causes of liver cancer.This article reviews the characteristics and the progress of NASH-HCC in diagnosis and treatment.

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