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中华消化病与影像杂志(电子版) ›› 2022, Vol. 12 ›› Issue (01) : 16 -19. doi: 10.3877/cma.j.issn.2095-2015.2022.01.004

论著

缓解期溃疡性结肠炎患者功能性肠道症状调查分析
惠慧1,(), 徐东燕2, 赵海剑3, 孙静4   
  1. 1. 223002 江苏省,徐州医科大学附属淮安医院手术室
    2. 223002 江苏省,徐州医科大学附属淮安医院消化内科
    3. 223002 江苏省,徐州医科大学附属淮安医院普外科
    4. 214023 江苏省,无锡市人民医院消化内科
  • 收稿日期:2021-04-27 出版日期:2022-02-01
  • 通信作者: 惠慧
  • 基金资助:
    国家自然科学基金(81800490); 江苏省六大人才高峰工程(WSW-220)

Investigation and analysis of functional intestinal symptoms in patients with remission ulcerative colitis

Hui Hui1,(), Dongyan Xu2, Haijian Zhao3, Jing Sun4   

  1. 1. Operating Room, Huai′an Hospital Affiliated to Xuzhou Medical University, Xuzhou 223002, China
    2. Department of Gastroenterology, Huai′an Hospital Affiliated to Xuzhou Medical University, Xuzhou 223002, China
    3. Department of General Surgery, Huai′an Hospital Affiliated to Xuzhou Medical University, Xuzhou 223002, China
    4. Department of Gastroenterology, Wuxi People′s Hospital, Wuxi 214023, China
  • Received:2021-04-27 Published:2022-02-01
  • Corresponding author: Hui Hui
引用本文:

惠慧, 徐东燕, 赵海剑, 孙静. 缓解期溃疡性结肠炎患者功能性肠道症状调查分析[J/OL]. 中华消化病与影像杂志(电子版), 2022, 12(01): 16-19.

Hui Hui, Dongyan Xu, Haijian Zhao, Jing Sun. Investigation and analysis of functional intestinal symptoms in patients with remission ulcerative colitis[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(01): 16-19.

目的

了解缓解期溃疡性结肠炎(UC)患者功能性肠道症状发生的频率,并探讨其与患者抑郁、焦虑及生活质量相关性。

方法

选取2016年5月至2020年3月徐州医科大学附属淮安医院就诊的临床缓解期UC患者326例,并选取其中无功能性肠道症状患者20例为对照组。采用一般资料调查表、医院焦虑和抑郁量表、大便失禁评分量表、粪失禁生活质量评分系统、便秘患者生活质量自评问卷对患者进行调查。采用Pearson相关性分析功能性肠道症状与抑郁、焦虑及生活质量的相关性。

结果

共收回有效问卷300例,8%患者出现过大便失禁症状,10%患者出现过便秘。有功能性肠道症状患者焦虑评分、抑郁评分显著高于对照组患者,差异均有统计学意义(P<0.05);有功能性肠道症状患者生活质量显著低于对照组患者,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,患者大便失禁及便秘评分与焦虑、抑郁评分均呈显著正相关(P<0.01);大便失禁评分与生活质量评分呈显著负相关(r=-0.863,P<0.01),便秘评分与生活质量分呈显著正相关(r=0.881,P<0.01)。

结论

缓解期UC患者仍会出现功能性肠道症状,并且功能性肠道症状增加了患者负性情绪,影响了患者生活质量。

Objective

To investigate the frequency of functional intestinal symptoms in patients with ulcerative colitis in remission stage and its correlation with depression, anxiety and quality of life.

Methods

A total of 326 patients with ulcerative colitis in remission stage from May 2016 to March 2020 were selected, and 20 patients without functional intestinal symptoms were selected as the control group.General information questionnaire, hospital anxiety and depression scale, fecal incontinence score scale, fecal incontinence quality of life score system and constipation patients quality of life questionnaire were used to investigate the patients.Pearson correlation analysis was used to analyze the correlation between functional intestinal symptoms and depression, anxiety and quality of life.

Results

A total of 300 valid questionnaires were collected, 8% of the patients had symptoms of fecal incontinence, and 10% of the patients had constipation.The scores of anxiety and depression in patients with functional intestinal symptoms were significantly higher than those in the control group(all P<0.05). The quality of life of patients with functional intestinal symptoms was significantly lower than that of the control group(P<0.05). Pearson correlation analysis showed that the scores of fecal incontinence and constipation were positively correlated with the scores of anxiety and depression(P<0.01). There was a significant negative correlation between fecal incontinence score and quality of life score(r=-0.863, P<0.01), and a significant positive correlation between constipation score and quality of life score(r=0.881, P<0.01).

Conclusion

Patients with remission UC still have functional intestinal symptoms, and functional intestinal symptoms increase the negative emotions of patients and affect the quality of life of patients.

表1 三组患者一般情况比较
表2 大便失禁组与对照组焦虑、抑郁、生活质量评分比较(分,±s)
表3 便秘组与对照组焦虑、抑郁、生活质量评分比较(分,±s)
图1 大便失禁及便秘评分与焦虑评分相关性分析
图2 大便失禁及便秘评分与抑郁评分相关性分析
图3 大便失禁及便秘评分与生活质量评分相关性分析
1
Bernstein CN,,Nugent Z,,Singh H.Persistently High Rate of Venous Thromboembolic Disease in Inflammatory Bowel Disease:A Population-Based Study[J].Am J Gastroenterol2021116(7):1476-1484.
2
Crocetti Emanuele,,Bergamaschi Walter,,Russo Antonio Giampiero.Population-based incidence and prevalence of inflammatory bowel diseases in Milan(Northern Italy),and estimates for Italy[J].Eur J Gastroenterol Hepatol2021 Mar 25.
3
Tarcia Nogueira Ferreira Gomes,de Azevedo Fabio Silva,,Argollo Marjorie,et al.Clinical and Demographic Profile of Inflammatory Bowel Disease Patients in a Reference Center of São Paulo,Brazil [J].Clin Exp Gastroenterol202114:91-102.
4
中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见(2018年·北京)[J].中华炎性肠病杂志(中英文)20182(3)173-190.
5
Kim MC,,Jung YS,,Song YS,et al.Factors associated with anxiety and depression in Korean patients with inactive inflammatory bowel disease[J].Gut Liver201610(3):399-405.
6
Rao SS,American CoHege of Gastroenterology Practice Parameters Committee.Diagnosis and management of fecal incontinence.American college of gastroenterology practice parameters committee[J].Am J Gastroenterol200499(8):1585-1604.
7
Kearney BY,,Fleischer BJ.Development of an instrument to measure exercise of self-care agency [J].Res Nurs Health19792(1):25-34.
8
Agachan F,,Chen T,,Pfeifer J,et al.A constipation scoring system to simplify evaluation and management of constipated patients [J].Dis Colon Rectum199639:681-685.
9
Marquis P,,De La Loge C,,Dubois D,et al.Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire[J].Scand J Gastroenterol200540:540-551.
10
Gu P,,Kuenzig ME,,Kaplan GG,et al.Fecal incontinence in inflammatory bowel disease:a systematic review and metaanalysis[J].Inflamm Bowel Dis201824:1280-1290.
11
Flor L,,Minguez M,,Tosca J,et al.Fecal incontinence(FI)in patients with inflammatory bowel disease(IBD).Probably as important as prevalent.sa1129 [J].Gastroenterology2014146:s207-s207.
12
Farrokhyar F,,Marshall JK,,Easterbrook B,et al.Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease:prevalence and impact on health[J].Inflamm.Bowel Dis200612:38-46.
13
Bengtsson J,,Borjesson L,,Lundstam U,et al.Long-term function and manovolumetric characteristics after ileal pouch-anal anastomosis for ulcerative colitis[J].Br J Surg200794:327-332.
14
Ishak WW,,Pand N,,Steiner AJ,et al.Patient-reported outcomes of quality of life,functioning,and GI/psychiatric symptom severity in patients with inflammatory bowel disease(IBD)[J].Inflamm Bowel Dis201723(5):798-803.
15
齐妍妍,王爱平.炎症性肠病患者大便失禁现状调查及其影响因素分析[J].中华现代护理201824(19):2323-2327.
16
黄钢丁,叶进.慢性便秘与精神心理因素关系的研究进展[J].临床消化病杂志201931(3):187-189.
17
陈晨,戴新娟.炎症性肠病患者生活质量与自我效能、焦虑、抑郁水平的相关性研究[J].护理研究201630(28):556-559.
18
李娟,陈银芸,陈钢,等.生物反馈联合精神心理治疗对功能性便秘的临床疗效[J].中国现代医学杂志2016(3):141-144.
19
Ouizeman Dann Joseph,,Marine-Barjoan Eugenia,,Chelles Audrey Hastier-De.The severity of symptoms is insufficient to predict major alterations to quality of life of patients with fecal incontinence or chronic constipation[J].Int J Colorectal Dis202035(11):2041-2048.
20
Vollebregt PF,,Van Bodegraven AA,,Markus-de Kwaadsteniet TML,et al.Impacts of perianal disease and faecal incontinence on quality of life and employment in 1092 patients with inflammatory bowel disease[J].Aliment Pharmacol Ther201847(9):1253-1260.
21
Vivier Helize,,Ross Emily J,,Cassisi Jeffrey E.Classification of gastrointestinal symptom patterns in young adults[J].BMC Gastroenterol202020(1):326.
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