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中华消化病与影像杂志(电子版) ›› 2023, Vol. 13 ›› Issue (03) : 160 -166. doi: 10.3877/cma.j.issn.2095-2015.2023.03.007

综述

食管胃结合部腺癌的研究现状
黄文鹏, 李莉明, 高剑波()   
  1. 450052 郑州大学第一附属医院放射科
  • 收稿日期:2022-12-05 出版日期:2023-06-01
  • 通信作者: 高剑波
  • 基金资助:
    国家自然科学基金(81971615)

Current status of research on adenocarcinoma of gastroesophageal junction

Wenpeng Huang, Liming Li, Jianbo Gao()   

  1. Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2022-12-05 Published:2023-06-01
  • Corresponding author: Jianbo Gao
引用本文:

黄文鹏, 李莉明, 高剑波. 食管胃结合部腺癌的研究现状[J]. 中华消化病与影像杂志(电子版), 2023, 13(03): 160-166.

Wenpeng Huang, Liming Li, Jianbo Gao. Current status of research on adenocarcinoma of gastroesophageal junction[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(03): 160-166.

近年来,食管胃结合部腺癌(AGJ)的发病率逐年上升,备受关注。针对AGJ诊疗的难点问题,目前有更多临床研究和技术创新去逐步深入完善和解决。本文对基于AGJ的分型、分期、淋巴结引流特点和清扫范围、影像诊断、治疗方式的研究现状进行综述,以提高临床医生对其的认识和诊治水平。

In recent years, the incidence of adenocarcinoma of gastroesophageal junction(AGJ)has been increasing year by year and has attracted much attention.For the difficult problems of AGJ diagnosis and treatment, there are more clinical studies and technical innovations to gradually improve and solve them in depth.In this paper, we review the current status of research based on the classification, staging, lymph node drainage characteristics and clearance range, imaging diagnosis and treatment modalities of AGJ to improve clinicians′ understanding and treatment.

1
王杰,程启升,刘勇,等.SiewertⅡ型和Ⅲ型食管胃结合部腺癌手术中下纵隔淋巴结清扫的研究进展[J].中华消化外科杂志201918(3):292-296.
2
于振涛,王海通.食管胃结合部腺癌外科治疗现状[J].中华消化外科杂志201918(6):513-517.
3
周岩冰.食管胃结合部腺癌当前临床研究开展现状与挑战[J].中华胃肠外科杂志201922(2):112-118.
4
杜迎新,邓靖宇,梁寒,等.Siewert Ⅱ型和Ⅲ型食管胃结合部腺癌不同手术径路根治术预后影响因素分析[J].中华消化外科杂志202019(6):630-636.
5
尹俊,谭黎杰,方勇,等.从胸外科医师的视角探讨食管胃结合部腺癌外科治疗策略[J].中华消化外科杂志202019(6):604-608.
6
韩方海,杨斌.解读第15版日本胃癌处理规约[J].中华胃肠外科杂志201821(4):409-412.
7
Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging[J]. CA Cancer J Clin201767(2):93-99.
8
Zhou Y, Hou P, Zha K, et al. Spectral Computed Tomography for the Quantitative Assessment of Patients With Carcinoma of the Gastroesophageal Junction: Initial Differentiation Between a Diagnosis of Squamous Cell Carcinoma and Adenocarcinoma[J]. J Comput Assist Tomogr201943(2):187-193.
9
宋梦欣,闫君雅,仓顺东.食管胃结合部腺癌研究进展[J].中华实用诊断与治疗杂志202135(9):889-891.
10
Hamilton SR, Aaltonen LA. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System[M]. Lyon: International Agency for Research on Cancer(IARC) Press, 2000.
11
国际食管疾病学会中国分会(CSDE)食管胃结合部疾病跨界联盟,中国医师协会内镜医师分会腹腔镜外科专业委员会,中国医师协会外科医师分会上消化道外科医师专业委员会,中华医学会肿瘤分会胃肠肿瘤学组.食管胃结合部腺癌外科治疗中国专家共识(2018年版)[J].中华胃肠外科杂志201821(9):961-975.
12
鲁意迅,张珂诚,陈凛.食管胃结合部腺癌的多学科综合治疗[J].中华消化外科杂志201918(3):217-221.
13
Tang W, Chen S, Liu J, et al. Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk[J]. J Cell Biochem, 2019120(4):5510-5518.
14
Tang W, Liu J, Zhong Z, et al. Association of metabolism-related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects[J]. J Cell Biochem, 2019120(11):18689-18701.
15
Tang W, Wang Y, Pan H, et al. Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AGJ) risk and lymph node status[J]. Onco Targets Ther, 201912:6245-6252.
16
Cao R, Chen Y, Wang J, et al. Association of Long Noncoding RNAs Polymorphisms with the Risk of Esophagogastric Junction Adenocarcinoma: A Three-Center Study of 1063 Cases and 1677 Controls[J]. DNA Cell Biol, 202039(5):828-835.
17
Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction[J]. Br J Surg199885(11):1457-1459.
18
Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (ver. 4) [J]. Gastric Cancer, 201720(1):1-19.
19
Curtis NJ, Noble F, Bailey IS, et al. The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction[J]. J Surg Oncol, 2014109(3):202-7.
20
Rice TW, Ishwaran H, Ferguson MK, et al. Cancer of the Esophagus and Esophagogastric Junction: An Eighth Edition Staging Primer[J]. J Thorac Oncol, 201712(1):36-42.
21
Amin MB, Edge S, Greene FL, et al. AJCC Cancer Staging Manual (8th Ed) [M]. New York: Springer, 2017:185-202.
22
王伟,熊文俊,易小江,等.胸腔单孔辅助腹腔镜Siewert Ⅱ型进展期食管胃结合部腺癌根治术的临床应用[J].中华胃肠外科杂志201821(9):1065-1068.
23
Kitamura K, Yamaguchi T, Nishida S, et al. The operative indications for proximal gastrectomy in patients with gastric cancer in the upper third of the stomach[J]. Surg Today, 199727(11):993-998.
24
Cense HA, Sloof GW, Klaase JM, et al. Lymphatic drainage routes of the gastric cardia visualized by lymphoscintigraphy[J]. J Nucl Med, 200445(2):247-52.
25
徐泽宽,王林俊,李铮.食管胃结合部腺癌淋巴结清扫策略[J].中华消化外科杂志202120(6):631-634.
26
王海通,弓磊,张洪典,等.Siewert Ⅱ型食管胃结合部腺癌的淋巴结转移规律和预后影响因素分析[J].中华消化外科杂志201918(6):556-562.
27
Koyanagi K, Kato F, Kanamori J, et al. Clinical significance of esophageal invasion length for the prediction of mediastinal lymph node metastasis in Siewert type II adenocarcinoma: A retrospective single-institution study[J]. Ann Gastroenterol Surg, 20182(3):187-196.
28
Kurokawa Y, Hiki N, Yoshikawa T, et al. Mediastinal lymph node metastasis and recurrence in adenocarcinoma of the esophagogastric junction[J]. Surgery, 2015157(3):551-555.
29
胡祥.第5版日本《胃癌治疗指南》拔萃[J].中国实用外科杂志201838(4):396-406.
30
Kurokawa T, Kurokawa Y, Mori M, et al. Surgical Treatment of Gastroesophageal Junction Cancer[J]. J Gastric Cancer, 201818(3):209-217.
31
Kurokawa Y, Takeuchi H, Doki Y, et al. Mapping of Lymph Node Metastasis From Esophagogastric Junction Tumors: A Prospective Nationwide Multicenter Study[J]. Ann Surg, 2021274(1):120-127.
32
中华医学会外科学分会腹腔镜与内镜外科学组.Siewert Ⅱ型食管胃结合部腺癌腔镜手术治疗中国专家共识(2019版)[J].中国实用外科杂志201939(11):1129-1135.
33
刘天舟,王骏扬,刘晶晶,等.全腔镜下Siewert Ⅱ型食管胃结合部腺癌手术径路技术要点解析[J].中华消化外科杂志202019(6):615-619.
34
胡文庆,崔鹏,张晋杰,等.对食管胃结合部腺癌经腹食管裂孔入路进行下纵隔淋巴结清扫的认识[J].中华胃肠外科杂志201922(10):932-936.
35
唐磊,李佳铮.食管胃结合部腺癌浸润范围的影像学评价[J].中华胃肠外科杂志201922(2):119-125.
36
梁盼,赵曦曈,赵慧萍,等.CT对胃癌诊断和临床应用价值[J].中华放射学杂志202054(11):1141-1144.
37
徐志远,胡灿,余建法,等.进展期食管胃结合部腺癌经腹左胸入路全胃切除手术[J].中华胃肠外科杂志201821(10):1175-1177.
38
李斯婕,张倩雯,郝强.增强磁共振成像在Siewert Ⅱ/Ⅲ型食管胃结合部腺癌术前评估中的价值[J].第二军医大学学报202142(11):1252-1259.
39
曹晖,赵恩昊.食管胃结合部腺癌手术径路治疗策略的变迁与思考[J].中华消化外科杂志201918(6):518-522.
40
柰超,刘震,连肖,等.近端胃大部切除与全胃切除术治疗Siewert Ⅱ型食管胃结合部腺癌术后生存率的比较[J].中华胃肠外科杂志201619(2):195-199.
41
秦叔逵,李进.阿帕替尼治疗胃癌的临床应用专家共识[J].临床肿瘤学杂志2015(9):841-847.
42
Karanicolas PJ, Graham D, Gönen M, et al. Quality of life after gastrectomy for adenocarcinoma: a prospective cohort study[J]. Ann Surg, 2013257(6):1039-1046.
43
Van Cutsem E, Bang YJ, Feng-Yi F, et al. HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer[J]. Gastric Cancer, 201518(3):476-84.
44
杜迎新,邓靖宇,梁寒,等.Siewert Ⅱ型和Ⅲ型食管胃结合部腺癌不同手术径路根治术预后影响因素分析[J].中华消化外科杂志202019(6):630-636.
45
郑朝辉,郑华龙,陆俊.基于Siewert分型食管胃结合部腺癌的治疗策略[J].中华消化外科杂志201918(6):536-541.
46
言成一,陈龙奇.回眸2019--聚焦食管胃结合部肿瘤的外科治疗[J].中华胃肠外科杂志202023(1):20-25.
47
Hosoda K, Yamashita K, Katada N, et al. Impact of lower mediastinal lymphadenectomy for the treatment of esophagogastric junction carcinoma[J]. Anticancer Res, 201535(1):445-56.
48
Omloo JM, Lagarde SM, Hulscher JB, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial[J]. Ann Surg, 2007246(6):992-1000.
49
Li B, Hu H, Zhang Y, et al. Extended Right Thoracic Approach Compared With Limited Left Thoracic Approach for Patients With Middle and Lower Esophageal Squamous Cell Carcinoma: Three-year Survival of a Prospective, Randomized, Open-label Trial[J]. Ann Surg, 2018267(5):826-832.
50
张建锋,田洋,徐延昭,等.不同手术径路在Siewert Ⅱ型食管胃结合部腺癌根治术中的应用价值[J].中华消化外科杂志202120(6):675-682.
51
曹晖,赵恩昊.从"单打独斗"到"合作共赢":论多学科团队在食管胃结合部腺癌诊治中的现状和展望[J].中华消化外科杂志202120(6):617-624.
52
赵恩昊,曹晖.从腹部外科医师的视角审视食管胃结合部腺癌诊断与治疗策略之演变发展趋势[J].中华消化外科杂志202019(6):598-603.
53
Díez Del Val I, Loureiro González C, Asensio Gallego JI, et al. Minimally invasive and robotic surgery in the surgical treatment of esophagogastric junction cancer[J]. Cir Esp (Engl Ed), 201997(8):451-458.
54
程杰,黄博.基于Siewert分型:Ⅱ型食管胃结合部腺癌的争议进展[J].中国普外基础与临床杂志202128(9):1254-1260.
55
胡志豪,李瑞欣,王国俊.食管胃结合部腺癌的微创外科治疗现状与展望[J/OL].中华腔镜外科杂志(电子版)202114(3):181-186.
56
Li KK, Bao T, Wang YJ, et al. The Postoperative outcomes of thoracoscopic-laparoscopic Ivor-Lewis surgery plus D2 celiac lymphadenectomy for patients with adenocarcinoma of the esophagogastric junction[J]. Surg Endosc, 202034(11):4957-4966.
57
Mariette C, Markar SR, Dabakuyo-Yonli TS, et al. Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer[J]. N Engl J Med, 2019380(2):152-162.
58
Hyung WJ, Yang HK, Han SU, et al. A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03[J]. Gastric Cancer, 201922(1):214-222.
59
张俊,李珍,张同钦,等.胸腹腔镜微创术与开放Sweet食管切除术对SiewertⅡ型食管胃交界腺癌手术创伤的影响[J].中国医学装备202017(12):101-105.
60
刘天舟,王骏扬,刘晶晶,等.全腔镜下Siewert Ⅱ型食管胃结合部腺癌手术径路技术要点解析[J].中华消化外科杂志202019(6):615-619.
61
Huang CM, Lv CB, Lin JX, et al. Laparoscopic-assisted versus open total gastrectomy for Siewert type II and III esophagogastric junction carcinoma: a propensity score-matched case-control study[J]. Surg Endosc, 201731(9):3495-3503.
62
黄昌明,陈起跃.经腹食管裂孔入路的腹腔镜手术之一[J].中华胃肠外科杂志201821(8):881-882.
63
廖存香,冯青,李平昂,等.达芬奇机器人手术系统、腹腔镜与开腹手术治疗局部进展期Siewert Ⅱ型和Ⅲ型食管胃结合部腺癌近期疗效对比研究[J].中华消化外科杂志202019(6):620-629.
64
张珂诚,曹博,卫勃,等.机器人与腹腔镜辅助胃癌根治术中复杂部位淋巴结清扫对比研究[J].中国肿瘤临床201946(11):546-550.
65
王道胜,曹守根,谭晓杰,等.机器人与腹腔镜辅助手术对SiewertⅡ型食管胃结合部腺癌淋巴结清扫及近期结局的影响[J].中华胃肠外科杂志201922(2):156-163.
66
Parisi A, Reim D, Borghi F, et al. Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery[J]. World J Gastroenterol, 201723(13):2376-2384.
67
卓泽国,林一丹.胃-食管预制机器人胸内手工分层吻合的手术视频要求[J].中国胸心血管外科临床杂志2019, 26(6): 523.
68
郜永顺,孙建刚,张云飞,等.Siewert Ⅱ/Ⅲ型食管胃结合部腺癌上切缘安全距离界定[J].腹部外科202033(6):454-458.
69
梅相煌,王洋洋,郭伟,等.SiewertⅡ型进展期食管胃结合部腺癌近端切缘长度与近期临床疗效观察[J].中华医学杂志2021101(34):2698-2702.
70
李东亮,周家杰,杜瑞,等.腹腔镜辅助下三种消化道重建方式在食管胃结合部腺癌中的临床疗效分析[J/OL].中华腔镜外科杂志(电子版)202013(3):159-165.
71
徐泽宽,何中原,王林俊.近端胃切除术抗反流消化道重建方式的选择[J].中华消化外科杂志202019(9):935-940.
72
Yamashita Y, Yamamoto A, Tamamori Y, et al. Side overlap esophagogastrostomy to prevent reflux after proximal gastrectomy[J]. Gastric Cancer, 201720(4):728-735.
73
李东亮,王伟,周家杰,等.腹腔镜辅助下Overlap法管型胃食管吻合在食管胃结合部腺癌中临床疗效分析[J/OL].中华腔镜外科杂志(电子版)202013(6):357-361.
74
程启升,刘勇,梅相煌,等.食管胃结合部肿瘤近端胃切除防反流手术研究现状[J].中华胃肠外科杂志202023(10):1017-1022.
75
Komatsu S, Kosuga T, Kubota T, et al. Non-flap hand-sewn esophagogastrostomy as a simple anti-reflux procedure in laparoscopic proximal gastrectomy for gastric cancer[J]. Langenbecks Arch Surg, 2020405(4):541-549.
76
Wang B, Wu Y, Wang H, et al. Semi-embedded valve anastomosis a new anti-reflux anastomotic method after proximal gastrectomy for adenocarcinoma of the oesophagogastric junction[J]. BMC Surg, 202020(1):230.
77
熊杰,单治国,杨健,等.食管空肠半端端吻合与侧侧吻合在食管胃结合部腺癌腹腔镜根治性全胃切除术中的临床价值[J].中华消化外科杂志202019(11):1190-1195.
78
严倩,郑佳彬,李勇.全腹腔镜SiewertⅡ型胃食管结合部癌根治术现状[J/OL].中华腔镜外科杂志(电子版)201912(5):307-310.
79
赵红雨.Siewert Ⅱ、Ⅲ型食管胃结合部腺癌腹腔镜手术消化道重建方法的进展[J].中国微创外科杂志202020(8):744-749.
80
Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial[J]. Lancet, 2019393(10184):1948-1957.
81
中国临床肿瘤学会(CSCO).胃癌诊疗指南[M].北京:人民卫生出版社,2019.
82
Münch S, Habermehl D, Agha A, et al. Perioperative chemotherapy vs. neoadjuvant chemoradiation in gastroesophageal junction adenocarcinoma : A population-based evaluation of the Munich Cancer Registry[J]. Strahlenther Onkol, 2018194(2):125-135.
83
籍阳阳,彭涛,王国强,等.紫杉醇联合卡铂的新辅助同步放化疗方案应用于Ⅲ期食管胃结合部腺癌的近期疗效及安全性分析[J].中华胃肠外科杂志201821(9):1019-1024.
84
Shapiro J, van Lanschot JJB, Hulshof MCCM, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial[J]. Lancet Oncol, 201516(9):1090-1098.
85
Noordman BJ, Verdam MGE, Lagarde SM, et al. Impact of neoadjuvant chemoradiotherapy on health-related quality of life in long-term survivors of esophageal or junctional cancer: results from the randomized CROSS trial[J]. Ann Oncol, 201829(2):445-451.
86
Petrelli F, Ghidini M, Barni S, et al. Neoadjuvant chemoradiotherapy or chemotherapy for gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis[J]. Gastric Cancer, 201922(2):245-254.
87
田园,王强,王军,等.新辅助同步放化疗联合手术对比直接手术治疗Siewert Ⅱ、Ⅲ型食管胃结合部腺癌随机对照试验的远期预后分析[J].中华胃肠外科杂志202124(2):128-137.
88
Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 201666(2):115-32.
89
陈键,何裕隆.食管胃结合部腺癌的靶向治疗进展[J/OL].消化肿瘤杂志(电子版)201911(4):317-324.
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