切换至 "中华医学电子期刊资源库"

中华消化病与影像杂志(电子版) ›› 2023, Vol. 13 ›› Issue (03) : 167 -171. doi: 10.3877/cma.j.issn.2095-2015.2023.03.008

综述

新型生物材料在内镜黏膜下剥离术中的应用
刘晗, 李惠, 朱宇新, 于淼, 李莞盈, 王爽, 狄育竹, 宁丹丹, 曲波()   
  1. 150086 哈尔滨医科大学第二临床医学院;150086 哈尔滨医科大学附属第二医院消化内科
    150086 哈尔滨医科大学附属第二医院消化内科
  • 收稿日期:2022-11-28 出版日期:2023-06-01
  • 通信作者: 曲波
  • 基金资助:
    黑龙江省博士后科研启动基金(LBH-Q20111)

Application of novel biomaterials in endoscopic submucosal dissection

Han Liu, Hui Li, Yuxin Zhu, Miao Yu, Wanying Li, Shuang Wang, Yuzhu Di, Dandan Ning, Bo Qu()   

  1. Second Clinical College of Harbin Medical University, Harbin 150086, China; Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
  • Received:2022-11-28 Published:2023-06-01
  • Corresponding author: Bo Qu
引用本文:

刘晗, 李惠, 朱宇新, 于淼, 李莞盈, 王爽, 狄育竹, 宁丹丹, 曲波. 新型生物材料在内镜黏膜下剥离术中的应用[J/OL]. 中华消化病与影像杂志(电子版), 2023, 13(03): 167-171.

Han Liu, Hui Li, Yuxin Zhu, Miao Yu, Wanying Li, Shuang Wang, Yuzhu Di, Dandan Ning, Bo Qu. Application of novel biomaterials in endoscopic submucosal dissection[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(03): 167-171.

内镜黏膜下剥离术(ESD)被广泛应用于消化道肿瘤的早期诊断及治疗,但ESD会造成医源性溃疡,并可能存在出血和穿孔等并发症,现有的术后治疗措施,如抑酸、黏膜保护药物的应用及术中电凝、止血夹止血都存在着一定的局限性。因此,需要先进的创面管理措施来促进ESD术后愈合及预防并发症,本文就近年来新型生物材料在ESD术后的应用研究及其机制做一综述,以期促进进一步的相关研究。

Endoscopic submucosal dissection(ESD)is widely used in the early diagnosis and treatment of gastrointestinal tumors.However, ESD may cause iatrogenic ulcers and be accompanied by complications such as bleeding and perforation.The existing treatment measures after ESD, such as the application of the antacids and the mucosa protectors have certain limitations, and there are also shortcomings of electrocoagulation and hemostatic clips.Therefore, advanced wound management measures are needed to promote postoperative wound healing and prevent complications.We review the application and mechanism of novel biomaterials in ESD according to literatures for the past few years, in order to promote the further related research.

表1 新型材料的类型及特点
图1 新型材料覆盖创面及创面愈合过程
1
Kinami S, Funaki H, Fujita H, et al. Local resection of the stomach for gastric cancer [J]. Surg Today, 201747(6):651-659.
2
Suzuki H, Takizawa K, Hirasawa T, et al. Ichiro Oda for J-WEB/EGC group. Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: ′Real-world evidence′ in Japan [J]. Dig Endosc, 201931(1):30-39.
3
Basford PJ, George R, Nixon E, et al. Endoscopic resection of sporadic duodenal adenomas: comparison of endoscopic mucosal resection (EMR) with hybrid endoscopic submucosal dissection (ESD) techniques and the risks of late delayed bleeding [J]. Surg Endosc201428(5):1594-1600.
4
Saito Y, Uraoka T, Matsuda T,et al. Endoscopic treatment of large superficial colorectal tumors: a case series of 200 endoscopic submucosal dissections (with video) [J]. Gastrointest Endosc, 200766(5):966-973.
5
Maeng JH, Bang BW, Lee E,et al. Endoscopic application of EGF-chitosan hydrogel for precipitated healing of GI peptic ulcers and mucosectomy-induced ulcers [J]. J Mater Sci Mater Med, 201425(2):573-582.
6
Lim JH, Kim SG, Choi J, et al. Risk factors of delayed ulcer healing after gastric endoscopic submucosal dissection [J]. Surg Endosc201529(12):3666-3673.
7
Kakushima N, Fujishiro M, Yahagi N,et al. Helicobacter pylori status and the extent of gastric atrophy do not affect ulcer healing after endoscopic submucosal dissection [J]. J Gastroenterol Hepatol, 200621(10):1586-1589.
8
Kobayashi M, Takeuchi M, Hashimoto S, et al. Contributing factors to gastric ulcer healing after endoscopic submucosal dissection including the promoting effect of rebamipide [J]. Dig Dis Sci, 201257(1):119-126.
9
Oh TH, Jung HY, Choi KD, et al. Degree of healing and healing-associated factors of endoscopic submucosal dissection-induced ulcers after pantoprazole therapy for 4 weeks [J]. Dig Dis Sci, 200954(7):1494-1499.
10
Ye BD, Cheon JH, Choi KD,et al. Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection: a prospective randomized controlled trial [J]. Aliment Pharmacol Ther, 200624(5):837-843.
11
Ohya TR, Endo H, Kawagoe K, et al. A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers [J]. World J Gastrointest Endosc, 20102(1):36-40.
12
Horikawa Y, Mimori N, Mizutamari H,et al. Proper muscle layer damage affects ulcer healing after gastric endoscopic submucosal dissection [J]. Dig Endosc201527(7):747-753.
13
Niimi K, Fujishiro M, Goto O, et al. Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection [J]. Dig Endosc201224(2):110-116.
14
Fujiwara S, Morita Y, Toyonaga T, et al. A randomized controlled trial of rebamipide plus rabeprazole for the healing of artificial ulcers after endoscopic submucosal dissection [J]. J Gastroenterol, 201146(5):595-602.
15
Leaper DJ. Silver dressings: their role in wound management [J]. Int Wound J, 20063(4):282-294.
16
Lam SK, Ching CK. Sucralfate in clinical practice [J]. J Gastroenterol Hepatol19949(4):401-411.
17
Alonci G, Fiorini F, Riva P, et al. Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection [J]. ACS Appl Bio Mater, 20181(5):1301-1310.
18
Ono H, Yao K, Fujishiro M,et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition) [J]. Dig Endosc, 202133(1):4-20.
19
Tsuda Y, Ishihara M, Amako M, et al. Photocrosslinkable chitosan hydrogel can prevent bone formation in both rat skull and fibula bone defects [J]. Artif Organs, 200933(1):74-77.
20
Muzzarelli R, Tarsi R, Filippini O, et al. Antimicrobial properties of N-carboxybutyl chitosan [J]. Antimicrob Agents Chemother, 199034(10):2019-2023.
21
Rfbds A, Fcbds A, Ackb B, et al. Biopolymer-based films and membranes as wound dressings [J]. Biopolymer Membranes and Films, 2020:165-194.
22
Jiménez-Gómez CP, Cecilia JA. Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications [J]. Molecules, 202025(17):3981.
23
Yoo IK, Kim K, Song G, Koh MY, Lee MS, Yeniova Lee H, Cho JY. Endoscopic application of mussel-inspired phenolic chitosan as a hemostatic agent for gastrointestinal bleeding: A preclinical study in a heparinized pig model [J]. PLoS One, 202116(5):e0251145.
24
Peng X, Xia X, Xu X, et al. Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations [J]. Sci Adv, 20217(23):eabe8739.
25
Regnier A, Cazalot G, Cantaloube B. Topical treatment of non-healing corneal epithelial ulcers in dogs with aminocaproic acid[J]. Vet Rec, 2005157(17):510-513.
26
Phadke A, Zhang C, Arman B,et al. Rapid self-healing hydrogels [J]. Proc Natl Acad Sci USA, 2012109(12):4383-4388.
27
He J, Zhang Z, Yang Y, Ren F,et al. Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing [J]. Nanomicro Lett, 202113(1):80.
28
Uraoka T, Ochiai Y, Fujimoto A,et al. A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection-induced ulcer in the stomach [J]. Gastrointest Endosc, 201683(6):1259-1264.
29
Katsuyama S, Miyazaki Y, Kobayashi S, et al. Novel, infection-free, advanced hemostatic material: physical properties and preclinical efficacy [J]. Minim Invasive Ther Allied Technol, 202029(5):283-292.
30
Yoshida M, Goto N, Kawaguchi M, et al. Initial clinical trial of a novel hemostat, TDM-621, in the endoscopic treatments of the gastric tumors [J]. J Gastroenterol Hepatol, 201429 Suppl 4:77-79.
31
Aoki S, Sakata Y, Shimoda R, et al. High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model [J]. Gastrointest Endosc, 201785(5):1076-1085.
32
Narita T, Yunoki S, Ohyabu Y, et al. In situ gelation properties of a collagen-genipin sol with a potential for the treatment of gastrointestinal ulcers [J]. Med Devices (Auckl), 20169:429-439.
33
Uraoka T, Yunoki S, Kinoshita S, et al. Novel temperature-responsive, biodegradable and injectable collagen sol for the endoscopic closure of colonic perforation holes: Animal study (with videos) [J]. Dig Endosc, 202133(4):616-620.
34
Kwon CI, Kim G, Ko KH, et al. Bio-sheet graft therapy for artificial gastric ulcer after endoscopic submucosal dissection: an animal feasibility study [J]. Gastrointest Endosc, 201581(4):989-996.
35
Zhao LM, Gong M, Wang R, et al. Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter [J]. Regen Biomater, 20218(1):rbaa056.
36
Francesko A, Petkova P, Tzanov T. Hydrogel Dressings for Advanced Wound Management [J]. Curr Med Chem, 201825(41):5782-5797.
37
Church D, Elsayed S, Reid O, et al. Burn wound infections [J]. Clin Microbiol Rev, 200619(2):403-434.
38
Matica MA, Aachmann FL, Tøndervik A, et al. Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action [J]. Int J Mol Sci, 201920(23):5889.
39
Savard T, Beaulieu C, Boucher I, et al. Antimicrobial action of hydrolyzed chitosan against spoilage yeasts and lactic acid bacteria of fermented vegetables [J]. J Food Prot, 200265(5):828-833.
40
Shepherd J, Sarker P, Rimmer S, et al. Hyperbranched poly(NIPAM) polymers modified with antibiotics for the reduction of bacterial burden in infected human tissue engineered skin [J]. Biomaterials, 201132(1):258-267.
41
Tian J, Wong KK, Ho CM, et al. Topical delivery of silver nanoparticles promotes wound healing [J]. Chem Med Chem, 20072(1):129-136.
42
Jiang Y, Zhao W, Xu S, Wei J, et al. Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization [J]. Biomaterials, 2022280:121323.
43
Francesko A, Soares da Costa D, Reis RL, et al. Functional biopolymer-based matrices for modulation of chronic wound enzyme activities [J]. Acta Biomater, 20139(2):5216-5225.
[1] 宋玟焱, 杜美君, 陈佳丽, 石冰, 黄汉尧. 唇腭裂手术围手术期疼痛管理的研究进展及基于生物材料治疗新方法的展望[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 397-405.
[2] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[3] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[4] 赵丽霞, 王春霞, 陈一锋, 胡东平, 张维胜, 王涛, 张洪来. 内脏型肥胖对腹腔镜直肠癌根治术后早期并发症的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 35-39.
[5] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[6] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[7] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[8] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[9] 许杰, 李亚俊, 冯义文. SOX新辅助化疗后腹腔镜胃癌D2根治术与常规根治术治疗进展期胃癌的近期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 647-650.
[10] 康婵娟, 张海涛, 翟静洁. 胰管支架置入术治疗急性胆源性胰腺炎的效果及对患者肝功能、炎症因子水平的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 667-670.
[11] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[12] 刘柏隆, 周祥福. 女性尿失禁吊带手术并发症处理的经验分享[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 127-127.
[13] 嵇振岭, 陈杰, 唐健雄. 重视复杂腹壁疝手术并发症的预防和处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 601-606.
[14] 江志鹏, 钟克力, 陈双. 复杂腹壁疝手术后腹腔高压与腹腔间室综合征的预防和处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 612-615.
[15] 石阳, 于剑锋, 曹可, 翟志伟, 叶春祥, 王振军, 韩加刚. 可扩张金属支架置入联合新辅助化疗治疗完全梗阻性左半结肠癌围手术期并发症分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 464-471.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?