分析凝血功能指标、血脂水平、C反应蛋白（CRP）及中性粒细胞/淋巴细胞比值（NLR）对克罗恩病（CD）活动性评估及临床诊断的价值。

选取2019年1月至2023年6月苏州大学附属第三医院收治的197例CD患者，纳入CD组，选取同期50名健康体检者，纳入对照组。检测2组受试者入组时凝血功能、血脂、CRP、NLR水平，并比较不同CD活动指数（CDAI）患者上述指标差异。使用受试者工作特征曲线（ROC），分析凝血功能、血脂、CRP、NLR评估CD活动性、诊断CD的截断值和效能及曲线下面积（AUC）。

197例CD患者中，130例（65.99%）处于活动期，67例（34.01%）处于缓解期。CD组APTT、FIB、INR高于对照组；活动期组PT、FIB、INR高于缓解期组，且APTT、FIB、INR高于对照组，缓解期组APTT、FIB、INR高于对照组（P<0.05）。CD组TG、TC、LDL-C、HDL-C均低于对照组；活动期组TG、TC、LDL-C、HDL-C均低于缓解期组和对照组（P<0.05），缓解期组血脂指标与对照组比较，差异无统计学意义（P>0.05）。CD组CRP、NLR高于对照组，活动期组CRP、NLR高于缓解期组和对照组，缓解期组CRP、NLR高于对照组（P<0.05）。ROC曲线示，凝血功能指标、血脂、CRP、NLR联合评估CD活动性的AUC为0.783，灵敏度、特异性分别为80.44%、81.97%；诊断CD的AUC为0.725，灵敏度、特异性分别为76.71%、78.44%。

CD患者存在明显凝血功能、血脂水平及CRP、NLR异常，且活动期CD患者上述病理改变更为显著，检测上述指标能够为CD活动性评估及临床辅助诊断提供参考。

To analyze the value of coagulation function index, blood lipid level, C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) in the activity evaluation and clinical diagnosis of Crohn's disease (CD).

A total of 197 patients with CD admitted to The Third Affiliated Hospital of Soochow University from January 2019 to June 2023 were included in CD group, and 50 healthy people were selected in the same period and included in control group. The levels of coagulation function, blood lipid, CRP and NLR were detected when the two groups entered the group, and the differences of the above indexes between patients with different CD activity index (CDAI) were compared. Receiver operating characteristic curve (ROC) was used to analyze the cutoff value, efficacy and area under curve (AUC) of coagulation function, blood lipid, CRP, NLR for evaluating CD activity and diagnosing CD.

Among 197 patients with CD, 130 (65.99%) were in active phase and 67 (34.01%) were in remission. APTT, FIB and INR in the CD group were higher than those in the control group; PT, FIB and INR in the active group were higher than those in the remission group, and their APTT, FIB and INR were higher than those in the control group. APTT, FIB and INR in the remission group were higher than those in the control group (P<0.05). TG, TC, LDL-C and HDL-C in the CD group were lower than those in the control group. TG, TC, LDL-C and HDL-C in the active group were lower than those in the remission group and control group (P<0.05). There was no statistically significant difference in blood lipid indicators between the remission group and control group (P>0.05). CRP and NLR in the CD group were higher than those in the control group; while the CRP and NLR in the active group were higher than those in the remission group and control group. The CRP and NLR in the remission group were higher than those in the control group (P<0.05). ROC curve showed that the AUC of coagulation function index, blood lipid, CRP and NLR combined to evaluate CD activity was 0.783, and the sensitivity and specificity were 80.44% and 81.97%, respectively. The AUC of diagnosing CD was 0.725, and the sensitivity and specificity were 76.71% and 78.44%, respectively.

There are obvious abnormalities in coagulation function, blood lipid level, CRP and NLR in CD patients, and the above pathological changes are more significant in active CD patients. Therefore, detecting these indexes can provide some reference for CD activity evaluation and clinical auxiliary diagnosis.