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中华消化病与影像杂志(电子版) ›› 2017, Vol. 07 ›› Issue (05) : 205 -210. doi: 10.3877/cma.j.issn.2095-2015.2017.05.004

所属专题: 文献

循证医学

胃食管反流病患者幽门螺杆菌感染率的Meta分析
孔洋洋1, 刘立新2,()   
  1. 1. 030001 太原,山西医科大学第一医院消化科在读硕士研究生
    2. 030001 太原,山西医科大学第一医院科研实验中心;030001 太原,山西医科大学第一医院消化科
  • 收稿日期:2016-11-04 出版日期:2017-10-01
  • 通信作者: 刘立新

Infection rate of Helicobacter pylori in patients with gastroesophageal reflux disease: a Meta-analysis

Yangyang Kong1, Lixin Liu2,()   

  1. 1. Postgraduate Student, Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
    2. Experimental Center of Science and Research, First Hospital of Shanxi Medical University, Taiyuan 030001, China; Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2016-11-04 Published:2017-10-01
  • Corresponding author: Lixin Liu
  • About author:
    Corresponding author: Liu Lixin, Email:
引用本文:

孔洋洋, 刘立新. 胃食管反流病患者幽门螺杆菌感染率的Meta分析[J/OL]. 中华消化病与影像杂志(电子版), 2017, 07(05): 205-210.

Yangyang Kong, Lixin Liu. Infection rate of Helicobacter pylori in patients with gastroesophageal reflux disease: a Meta-analysis[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(05): 205-210.

目的

对近15年来有关幽门螺杆菌(Helicobacter pylori,Hp)与胃食管反流病(gastroesophageal reflux disease,GERD)的国内外21篇文献进行Meta分析,探讨Hp与GERD的关系。

方法

在Pubmed、Ovid、中国知网、万方等数据库检索2001-2016年公开发表的有关Hp与GERD的中外文文献,并对文献进行筛选,应用Stata12.0软件进行数据分析。

结果

对最终纳入的21篇文献分析显示:(1)GERD组Hp感染率低于正常对照组(OR=0.56,95% CI:0.46~0.68);(2)GERD中糜烂性食管炎(erosive esophagitis,EE)分型组Hp感染率低于正常对照组(OR=0.46,95% CI:0.35~0.61);(3)GERD中Barrett食管(Barrett′s esophagus,BE)分型组Hp感染率均低于正常对照组(OR=0.43,95% CI:0.30~0.62);(4)EE组LA-CD与LA-AB间比较差异无统计学意义(OR=0.39,95% CI:0.10~1.57)。

结论

GERD患者Hp感染率较正常人低,推测Hp可能对GERD具有保护作用,与EE严重程度无关。

Objective

To analyze 21 documents published in Chinese and foreign languages about Helicobacter pylori(Hp)and gastroesophageal reflux disease(GERD)in the past 15 years by Meta-analysis, and to investigate the relationship between Hp and GERD.

Methods

The Chinese and foreign literatures about Hp and GERD published from 2001 to 2016 were searched and screened through PubMed, Ovid, China National Knowledge Infrastructure(CNKI)and Wanfang Database.The data were analyzed by using Stata12.0 software.

Results

The analysis results of 21 studies showed that: ①The infection rate of Hp in GERD group was lower than that in the normal control group(OR=0.56, 95% CI: 0.46-0.68); ②The infection rate of Hp in erosive esophagitis(EE)typing of GERD was lower than that in the normal control group(OR=0.46, 95% CI: 0.35-0.61); ③The infection rate of Hp in Barrett′s esophagus(BE)typing of GERD was lower than that in the normal control group(OR=0.43, 95% CI: 0.30-0.62); ④There was no significant difference between LA-CD and LA-AB of EE(OR=0.39, 95% CI: 0.10-1.57).

Conclusions

The infection rate of Hp in GERD patients is lower than that in the normal people.We speculate that Hp may have a protective effect on GERD and not be relevant to the severity of EE.

表1 纳入的21篇文献基本情况
图1 胃食管反流病患者与正常对照组幽门螺杆菌感染率比较
图2 糜烂性食管炎患者与正常对照组幽门螺杆菌感染率比较
图3 Barrett食管患者与正常对照组幽门螺杆菌感染率比较
图4 糜烂性食管炎不同内镜分级间幽门螺杆菌感染率比较
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