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中华消化病与影像杂志(电子版) ›› 2017, Vol. 07 ›› Issue (05) : 200 -204. doi: 10.3877/cma.j.issn.2095-2015.2017.05.003

所属专题: 文献

临床研究

Viatorr覆膜支架在经颈静脉肝内门体静脉分流术中的临床应用
亓皓亮1, 王广川1, 张明艳1, 冯华1, 史永军1, 张俊勇1, 张春清1,()   
  1. 1. 250014 济南,山东大学附属省立医院消化内科
  • 收稿日期:2016-12-27 出版日期:2017-10-01
  • 通信作者: 张春清

Clinical application of Viatorr covered stent in transjugular intrahepatic portosystemic shunt

Haoliang Qi1, Guangchuan Wang1, Mingyan Zhang1, Hua Feng1, Yongjun Shi1, Junyong Zhang1, Chunqing Zhang1,()   

  1. 1. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, China
  • Received:2016-12-27 Published:2017-10-01
  • Corresponding author: Chunqing Zhang
  • About author:
    Corresponding author: Zhang Chunqing, Email:
引用本文:

亓皓亮, 王广川, 张明艳, 冯华, 史永军, 张俊勇, 张春清. Viatorr覆膜支架在经颈静脉肝内门体静脉分流术中的临床应用[J]. 中华消化病与影像杂志(电子版), 2017, 07(05): 200-204.

Haoliang Qi, Guangchuan Wang, Mingyan Zhang, Hua Feng, Yongjun Shi, Junyong Zhang, Chunqing Zhang. Clinical application of Viatorr covered stent in transjugular intrahepatic portosystemic shunt[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(05): 200-204.

目的

探讨Viatorr覆膜支架在经颈静脉肝内门体静脉分流术(transjugular intrahepatic portosystemic shunt,TIPS)治疗肝硬化门静脉高压症的初期疗效。

方法

2015年10月至2016年10月山东大学附属省立医院9例肝硬化门脉高压合并静脉曲张出血患者采用Viatorr覆膜支架行TIPS治疗,术后1~3个月复查胃镜、超声,以后每半年复查一次,所有病例术后均行彩色多普勒超声及强化CT检查,对临床疗效及并发症情况进行回顾性分析。

结果

9例患者均一次性操作成功,技术成功率为100%;TIPS前后门静脉压力分别为(31.22±4.92)mmHg和(18.44±3.58)mmHg(1 mmHg=0.133 kPa,配对t检验,t=10,P<0.001),分流后门静脉压力较分流前平均降低(40.57±8.86)%。9例均获随访,随访时间为1~12个月(平均194 d)。随访过程中1例于术后148 d腹腔感染死亡;1例术后83 d出现自发性腹膜炎并感染性休克,经抗感染治疗后好转;1例术后23 d因服用阿司匹林致溃疡病出血,停用阿司匹林后,患者黑便消失;其余6例既往反复曲张静脉出血的患者,术后1~3个月复查胃镜均示曲张静脉缓解或消失,随访结束时均未出现呕血、黑便等症状。所有患者至随访结束(或死亡前)TIPS分流通道血流通畅,均未出现肝性脑病症状。

结论

Viatorr覆膜支架能维持分流道的长久通畅,降低再出血率,且术后肝性脑病并发率低,为门脉高压症患者的肝内门体静脉分流提供了一种安全、有效的治疗方法。

Objective

To discuss the early curative effect of Viatorr covered stent used in transjugular intrahepatic portosystemic shunt(TIPS)treating cirrhotic portal hypertension.

Methods

Nine cirrhotic patients with portal hypertension combined with variceal hemorrhage in Shandong Provincial Hospital Affiliated to Shandong University between October 2015 and October 2016 were included.All of them received TIPS treatment using Viatorr covered stent.They underwent gastroscopy and ultrasound re-examination at 1-3 months after operation and re-examined every half a year.All patients underwent color Doppler ultrasound and enhanced CT examination after operation.The clinical curative effect and complication condition were analyzed retrospectively.

Results

Nine patients were operated successfully in one time and the successful rate of the technique was 100%.Portal pressure before and after TIPS were(31.22±4.92)mmHg and(18.44±3.58)mmHg(1 mmHg=0.133 kPa, pairing t test, t=10, P<0.001), respectively.The pressure decreased by(40.57±8.86)% after shunt compared with before.All 9 cases were followed up and the follow-up visit length was 1-12 months(averagely 194 days). During the follow-up, 1 patient died at 148 d after operation due to abdominal infection; 1 patient got spontaneous peritonitis and infectious shock at 83 d after operation and got recovery with anti-infection treatment; 1 patient got ulcerative bleeding caused by aspirin at 23 d after operation and the tarry stool disappeared after stopping taking aspirin; for the other 6 cases with repeated varicosed vein bleeding, the gastroscope examination at 1-3 months after operation showed that varicosed veins were relieved or disappeared and they got no symptom including haematemesis, tarry stool till the end of the follow-up visits.All patients got smooth TIPS shunts till the end of follow-up visits(or before death)and they had no symptoms of hepatic encephalopathy.

Conclusions

Viatorr covered stent can maintain the long-term circulation of shunts, reduce the rebreeding rate and lower the postoperative coincidence rate of hepatic encephalopathy, so it is a safe and effective treatment method for intrahepatic portosystemic stent shunt of patients with portal hypertension.

图5 将外鞘后退至下腔静脉,后退支架有一定阻力时,释放覆膜支架。支架释放后,金属标记环位于门静脉穿刺点。覆膜支架远端进入下腔静脉
表1 9例肝硬化患者经颈静脉肝内门体静脉分流术前后肝功能及凝血指标变化(±s)
1
Weber CN, Nadolski GJ, White SB, et al.Long-Term Patency and Clinical Analysis of Expanded Polytetrafluoroethylene-Covered Transjugular Intrahepatic Portosystemic Shunt Stent Grafts[J]. J Vasc Interv Radiol, 2015, 26(9): 1257-1265.
2
Saad WE, Saad NE, Davies MG, et al.Elective transjugular intrahepatic portosystemic shunt creation for portal decompression in the immediate pretransplantation period in adult living related liver transplant recipient candidates: preliminary results[J]. J Vasc Interv Radiol, 2006, 17(6): 995-1002.
3
Funaki B. Transjugular intrahepatic portosystemic shunt.Semin Intervent Radiol, 2008, 25(2): 168-174.
4
Rössle M, Siegerstetter V, Huber M, Ochs A. The first decade of the transjugular intrahepatic portosystemic shunt(TIPS): state of the art[J]. Liver, 1998, 18(2): 73-89.
5
Biecker E. Diagnosis and therapy of ascites in liver cirrhosis[J]. World J Gastroenterol, 2011, 17(10): 1237-1248.
6
Fidelman N, Kwan SW, LaBerge JM, Gordon RL, Ring EJ, Kerlan RK.The transjugular intrahepatic portosystemic shunt: an update[J]. AJR Am J Roentgenol, 2012, 199(4): 746-755.
7
Merli M, Salerno F, Riggio O, et al.Transjugular intrahepatic portosystemic shunt versus endoscopic sclerotherapy for the prevention of variceal bleeding in cirrhosis: a randomized multicenter trial.Gruppo Italiano Studio TIPS(G.I.S.T.)[J]. Hepatology, 1998, 27(1): 48-53.
8
Saxon RR, Mendel-Hartvig J, Corless CL, et al.Bile duct injury as a major cause of stenosis and occlusion in transjugular intrahepatic portosystemic shunts: comparative histopathologic analysis in humans and swine[J]. J Vasc Interv Radiol, 1996, 7(4): 487-497.
9
LaBerge JM, Ferrell LD, Ring EJ, et al.Histopathologic study of stenotic and occluded transjugular intrahepatic portosystemic shunts[J]. J Vasc Interv Radiol, 1993, 4(6): 779-786.
10
卢勤,滕皋军.经颈静脉肝内门腔静脉分流术中胆汁漏出对内皮细胞生长及功能的影响[J].中华放射学杂志,2002,36(8):698-701.
11
Otal P, Rousseau H, Vinel JP, et al.High occlusion rate in experimental transjugular intrahepatic portosystemic shunt created with a Dacron-covered nitinol stent[J]. J Vasc Interv Radiol, 1999, 10(2 Pt 1): 183-188.
12
Riggio O, Ridola L, Lucidi C, Angeloni S. Emerging issues in the use of transjugular intrahepatic portosystemic shunt(TIPS)for management of portal hypertension: time to update the guidelines[J]. Dig Liver Dis, 2010, 42(7): 462-467.
13
Bureau C, Pagan JC, Layrargues GP, et al.Patency of stents covered with polytetrafluoroethylene in patients treated by transjugular intrahepatic portosystemic shunts: long-term results of a randomized multicentre study[J]. Liver Int, 2007, 27(6): 742-747.
14
Rossi P, Salvatori FM, Fanelli F, et al.Polytetrafluoroethylene-covered nitinol stent-graft for transjugular intrahepatic portosystemic shunt creation: 3-year experience[J]. Radiology, 2004, 231(3): 820-830.
15
Angeloni S, Merli M, Salvatori FM, et al.Polytetrafluoroethylene-covered stent grafts for TIPS procedure: 1-year patency and clinical results[J]. Am J Gastroenterol, 2004, 99(2): 280-285.
16
Vignali C, Bargellini I, Grosso M, et al.TIPS with expanded polytetrafluoroethylene-covered stent: results of an Italian multicenter study[J]. AJR Am J Roentgenol, 2005, 185(2): 472-480.
17
Boyer TD, Haskal ZJ.The Role of Transjugular Intrahepatic Portosystemic Shunt(TIPS)in the Management of Portal Hypertension: update 2009[J]. Hepatology, 2010, 51(1): 306.
18
李常青,李洪璐,郭江,等.观察改良TIPS在治疗门静脉高压消化道出血中的应用[J].中华介入放射学电子杂志,2014,2(2):29-32.
19
王昌明,李选,傅军,等.组合支架精确覆盖技术与单一覆膜支架技术的前瞻性随机对照研究[J].介入放射学杂志,2014,23(1):18-23.
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