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中华消化病与影像杂志(电子版) ›› 2018, Vol. 08 ›› Issue (01) : 33 -38. doi: 10.3877/cma.j.issn.2095-2015.2018.01.008

所属专题: 文献

综述

托伐普坦治疗肝硬化难治性腹水的长期疗效
牛晓卫1, 刘同亭2,(), 田廷斌1, 吕佳敏1   
  1. 1. 250000 济南,山东中医药大学
    2. 250000 济南军区总医院消化内科
  • 收稿日期:2017-10-22 出版日期:2018-02-01
  • 通信作者: 刘同亭

Long-term efficacy of tolvaptan in liver cirrhosis patients with refractory ascites

Xiaowei Niu1, Tongting Liu2,(), Tingbin Tian1, Jiamin Lyu1   

  1. 1. Shandong Traditional Chinese Medicine University, Jinan 250000, China
    2. Department of Gastroenterology, Jinan Military General Hospital, Jinan 250000, China
  • Received:2017-10-22 Published:2018-02-01
  • Corresponding author: Tongting Liu
  • About author:
    Corresponding author: Liu Tongting, Email:
引用本文:

牛晓卫, 刘同亭, 田廷斌, 吕佳敏. 托伐普坦治疗肝硬化难治性腹水的长期疗效[J/OL]. 中华消化病与影像杂志(电子版), 2018, 08(01): 33-38.

Xiaowei Niu, Tongting Liu, Tingbin Tian, Jiamin Lyu. Long-term efficacy of tolvaptan in liver cirrhosis patients with refractory ascites[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2018, 08(01): 33-38.

托伐普坦作为新一代口服的选择性血管加压素受体拮抗剂,已经成为欧洲、日本及中国等国家地区用于治疗肝硬化难治性腹水的理想用药,而且被美国食品药品监督管理局推荐用于治疗高容量性、正容量性低钠血症,然而不足的是,大部分实验研究及临床观察仅限于托伐普坦的短期疗效评估,不能充分证实长期应用的可行性,本文通过查阅近期文献着重论述口服托伐普坦在治疗肝硬化难治性腹水的长期疗效和安全性。

Tolvaptan as a new generation of oral selective vasopressin receptor antagonist, has become the ideal drug for patients with cirrhosis refractory ascites in many countries such as Europe, Japan and China, and has been recommended by the United States Food and Drug Administration for hyponatremia treatment of high capacity, positive capacity.However, most of the experimental studies and clinical observations are limited to the assessment of short-term efficacy of tolvaptan, and can not adequately confirm the feasibility of its long-term use.In this review, we focus on the long-term efficacy and safety of oral tolvaptan in treatment of liver cirrhosis with refractory ascites by reviewing the recent literatures.

1
王淑珍,丁惠国.肝硬化顽固性腹水新的治疗模式及理念[J].中华肝脏病杂志,2017,25(4): 249-253.
2
Runyon BA.Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012 [J]. Hepatology, 2013, 57(4): 1651-1653.
3
Shiegto K, Kawaguchi T, Niizeki T, et al.Efficacy of peritoneovenous shunt for treating tolvaptan-resistant refractory ascites in a cirrhotic patient with portal vein thrombosis: A case report [J]. Oncol Lett, 2016, 11(5): 3205-3209.
4
Rai N, Singh B, Singh A, et al.Midodrine and tolvaptan in patients with cirrhosis and refractory or recurrent ascites: a randomised pilot study [J]. Liver Int, 2017, 37(3): 406-414.
5
Ming Z, Smyth DD, Lautt WW.Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosine [J]. Hepatology, 2002, 35(1): 167-175.
6
Jia JD, Xie W, Ding HG, et al.Utility and safety of tolvaptan in cirrhotic patients with hyponatremia: A prospective cohort study [J]. Ann Hepatol, 2017, 16(1): 123-132.
7
Hiramine Y, Uto H, Imamura Y, et al.Efficacy of vasopressin V2 receptor antagonist tolvaptan in treatment of hepatic edema[J]. Hepatol Res, 2017, 47(6): 542-557.
8
Hirai K, Shimomura T, Moriwaki H, et al.Risk factors for hypernatremia in patients with short-and long-term tolvaptan treatment [J]. Eur J Clin Pharmacol, 2016, 72(10): 1177-1183.
9
Cárdenas A1, Ginès P, Marotta P, et al.Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis [J]. J Hepatol, 2012, 56(3): 571-578.
10
Yamada T, Ohki T, Hayata Y, et al.Potential Effectiveness of Tolvaptan to Improve Ascites Unresponsive to Standard Diuretics and Overall Survival in Patients with Decompensated Liver Cirrhosis [J]. Clin Drug Invest, 2016, 36(10): 829-835.
11
Okita K, Sakaida I, Okada M, et al.A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis [J]. J Gastroenterol, 2010, 45(9): 979-987.
12
Kurosaki M, Izumi N. Tolvaptan for the Treatment of Refractory Ascites [J]. Int Med, 2016, 55(20): 2909-2910.
13
Kumars S, Berl T. Vasopressin antagonists in the treatment of water-retaining disorders [J]. Sem Nephrol, 2008, 28(3): 279-288.
14
King LS, Agre P. Pathophysiology of the aquaporin water channels [J]. Annu Rev Physiol, 1996, 58: 619-648.
15
Decaux G, Soupart A, Vassart G. Non-peptide arginine-vasopressin antagonists: the vaptans [J]. Lancet, 2008, 371(9624): 1624-1632.
16
Mori T, Ohsaki Y, Oba-Yabana I, et al.Diuretic usage for protection against end-organ damage in liver cirrhosis and heart failure [J]. Hepatol Res, 2017, 47(1): 11-22.
17
Xue H, Tang X. Effect of vasopressin on Na(+)-K(+)-2Cl(-)cotransporter(NKCC)and the signaling mechanisms on the murine late distal colon [J]. Eur J Pharmacol, 2016, 771: 241-246.
18
Gerbes AL, Gulberg V, Gines P, et al.Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial [J]. Gastroenterol, 2003, 124(4): 933-999.
19
Sakaida I, Kawazoe S, Kajimura K, et al.Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double-blind, placebo-controlled trial [J]. Hepatol Res, 2014, 44(1): 73-82.
20
Akiyama S, Ikeda K, Sezaki H, et al.Therapeutic effects of short-and intermediate-term tolvaptan administration for refractory ascites in patients with advanced liver cirrhosis [J]. Hepatol Res, 2015, 45(11): 1062-1070.
21
Kogiso T, Tokushige K, Hashimoto E, et al.Safety and efficacy of long-term tolvaptan therapy for decompensated liver cirrhosis [J]. Hepatol Res, 2016, 46(3): E194-E200.
22
Sakaida I, Terai S, Kurosaki M, et al.Effectiveness and safety of tolvaptan in liver cirrhosis patients with edema: Interim results of post-marketing surveillance of tolvaptan in liver cirrhosis(START study)[J]. Hepatol Res, 2017, 47(11): 1137-1146.
23
Pose E, Sola E, Piano S, et al.Limited Efficacy of Tolvaptan in Patients with Cirrhosis and Severe Hyponatremia: Real-Life Experience [J]. Am J Med, 2017, 130(3): 372-375.
24
Vandergheynst F, Brachet C, Heinrichs C, et al.Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports [J]. Nep Clin Pract, 2012, 120(3): c168-c172.
25
ESTEVA-FONT C, BACCARO M E, FERNANDEZ-LLAMA P, et al.Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome [J]. Hepatology, 2006, 44(6): 1555-1563.
26
Iwasa M, Ishihara T, Hasegawa H, et al.Cirrhosis-related hyponatremia and the role of tolvaptan [J]. Hepatol Res, 2015, 45(10): E163-E165.
27
Cordaba J, Garcia-Martinez R, Simon-Talero M. Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence [J]. Metab Brain Dis, 2010, 25(1): 73-80.
28
Guevara M, Baccardo ME, Ríos J, et al.Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration [J]. Liver Int, 2010, 30(8): 1137-1142.
29
Iwasa M, Takei Y. Pathophysiology and management of hepatic encephalopathy 2014 update: Ammonia toxicity and hyponatremia [J]. Hepatol Res, 2015, 45(12): 1155-1162.
30
Tanabe N, Takami T, Fujisawa K, et al.Effectiveness of tolvaptan monotherapy and low-dose furosemide/tolvaptan combination therapy for hepatoprotection and diuresis in a rat cirrhotic model [J]. J Clin BiochemNutr, 2017, 61(1): 53-59.
31
Yakushijin K, Yamamoto K, Kurata K, et al.Tolvaptan as an alternative treatment for refractory fluid retention associated with sinusoidal obstruction syndrome after allogeneic stem cell transplantation [J]. Int J Hematol, 2013, 97(2): 284-286.
32
Yi S, Jeon H, Yoon SH, et al.Pharmacokinetics and pharmacodynamics of oral tolvaptan administered in 15-to 60-mg single doses to healthy Korean men [J]. J Cardiovasc Pharmacol, 2012, 59(4): 315-322.
33
Okita K, Kawazeo S, Hasebe C, et al.Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double-blind, placebo-controlled trial [J]. Hepatol Res, 2014, 44(1): 83-91.
34
Sakaida I, Yamashita S, Kobayashi T, et al.Efficacy and safety of a 14-day administration of tolvaptan in the treatment of patients with ascites in hepatic oedema [J]. J Int Med Res, 2013, 41(3): 835-847.
35
Gines P, Guevara M. Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management [J]. Hepatology, 2008, 48(3): 1002-1010.
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