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中华消化病与影像杂志(电子版) ›› 2022, Vol. 12 ›› Issue (01) : 33 -37. doi: 10.3877/cma.j.issn.2095-2015.2022.01.008

论著

腹盆腔孤立性纤维瘤影像学表现与病理、免疫组化特征分析
胡伏干1, 邹金钊2,()   
  1. 1. 225600 江苏省扬州市高邮市临泽中心卫生院放射科
    2. 225001 江苏扬州,江苏省苏北人民医院影像科
  • 收稿日期:2021-11-15 出版日期:2022-02-01
  • 通信作者: 邹金钊

Imaging findings and pathological and immunohistochemical features of solitary fibroma tumor in the abdomen and pelvis

Fugan Hu1, Jinzhao Zou2,()   

  1. 1. Department of Radiology, Linze Health Center, Gaoyou City, Yangzhou, Jiangsu Province, Gaoyou 225600, China
    2. Department of Medical Imaging, Northern Jiangsu People′s Hospital, Jiangsu Province, Yangzhou 225001, China
  • Received:2021-11-15 Published:2022-02-01
  • Corresponding author: Jinzhao Zou
引用本文:

胡伏干, 邹金钊. 腹盆腔孤立性纤维瘤影像学表现与病理、免疫组化特征分析[J]. 中华消化病与影像杂志(电子版), 2022, 12(01): 33-37.

Fugan Hu, Jinzhao Zou. Imaging findings and pathological and immunohistochemical features of solitary fibroma tumor in the abdomen and pelvis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(01): 33-37.

目的

探讨腹盆腔孤立性纤维瘤的影像学表现及病理学特征。

方法

回顾性分析2015年3月至2021年3月江苏省苏北人民医院经手术病理证实的7例腹盆腔孤立性纤维瘤(SFT)患者的影像学资料,并与病理结果对照。

结果

7例SFT患者中男性6例,女性1例;平均年龄57(27~71)岁。1例仅行CT腹部平扫、6例行CT或MRI平扫、增强扫描。1例发生于胰腺,2例位于腹腔,4例位于盆腔。7例中仅1例为多发病灶,其余均为单发,病灶最大径平均值90 mm。CT平扫呈等密度影或伴有稍低密度影,密度均匀或不均匀,其中伴小囊变2例,钙化灶1例。增强扫描仅1例表现为均匀轻微强化,5例动脉期见强化血管影,4例实质期呈"地图样"强化。MRI T1WI呈稍低信号,T2WI呈等低或稍高、稍低混杂信号影,1例病灶见T2WI低信号血管流空影,增强扫描延迟性强化。7例中有2例发生术后转移,1例邻近骨质受侵犯。组织学上SFT主要由梭形细胞和胶原纤维组成,免疫组化主要表现为CD34高表达阳性,Ki-67低表达阳性,恶性SFT表现为CD34表达减弱,而Ki-67高表达。

结论

腹盆腔SFT较为少见,其影像学表现具有一定的特异性,且可反映其病理特征,有助于疾病的诊断及鉴别诊断。

Objective

To explore the imaging findings and pathological features of solitary fibroma tumor in the abdomen and pelvis.

Methods

The imaging findings of 7 cases pathologically confirmed solitary fibroma tumor(SFT)in the abdomen and pelvis were retrospectively reviewed from March 2015 to March 2021 in Northern Jiangsu People′s Hospital, and compared with the pathological features.

Results

Among the 7 SFT patients, there were 6 males and 1 female, with an average age of 57(27-71)years.One patient received only PLAIN CT scan of abdomen, and 6 patients received plain CT or MRI scan or enhanced CT scan.The tumor was located in pancreas(n=1), abdominal cavity(n=2), pelvic cavity(n=4). Only 1 case had multiple lesions, and the rest were single lesion.The average maximum diameter of the lesions was 90 mm.In plain CT, lesions showed iso-density or slightly low-density shadow with uniform or uneven density, and 2 cases with small cystic and 1 case with calcification.In enhanced images, only 1 case showed uniform slight enhancement, 5 cases showed enhanced vascular shadow in arterial phase, and 4 cases showed " map" enhancement in parenchymal phase.MRI showed slightly low signal intensity on T1WI, equal or slightly higher or slightly lower mixed signal intensity on T2WI, and empty signal intensity on T2WI was observed in 1 lesion, which showed delayed enhancement on enhanced scanning.Postoperative metastasis occurred in 2 of 7 cases, and adjacent bone invasion occurred in 1 case.Histologically, SFT was mainly composed of spindle cells and collagen fibers.Immunohistochemistry showed high expression of CD34 and low expression of Ki-67, while malignant SFT showed reduced expression of CD34 and high expression of Ki-67.

Conclusion

Abdominal and pelvic SFT is relatively rare, and its imaging manifestations have certain specificity, and can reflect its pathological features, which is helpful for the diagnosis and differential diagnosis of the disease.

图1 患者男,67岁,盆腔孤立性纤维瘤 注:1A平扫,1B动脉期、1C静脉期:CT平扫呈类圆形等密度肿块影,边界欠清,邻近骶骨受侵增强扫描动脉期见病灶内及周围迂曲走行血管影,静脉期呈延迟性强化;1D镜下瘤细胞呈胖梭形或卵圆形,细胞较丰富,核深染,可见少量核分裂象,呈束状、片状排列(HE×200);1E、1F:免疫组化显示CD34(灶区+)、Ki-67(+)约3%
图2 患者男,71岁,盆腔孤立性纤维瘤 注:肿块呈分叶状,边界尚清晰,MRI肿块信号欠均匀,T1WI以低信号为主(2A),T2以高信号为主,内见低信号流空血管影(2B),DWI呈高信号(2C)。2D动脉期、2E静脉期、2F延迟期:增强扫描可见病灶内及边缘强化血管影,病灶呈延迟性强化。该病灶在后续随访中发生转移。2G:镜下见增生的长梭形细胞,呈束状分布,细胞异型不明显,间质黏液样变(HE×200);2H、2I:免疫组化显示CD34(+)、Ki-67(+)约30%
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