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中华消化病与影像杂志(电子版) ›› 2024, Vol. 14 ›› Issue (01) : 77 -81. doi: 10.3877/cma.j.issn.2095-2015.2024.01.014

综述

原发性肝细胞癌肿瘤标志物研究进展
万菲1, 任勇军2,()   
  1. 1. 637000 四川南充,川北医学院附属医院放射科
    2. 637000 四川南充,川北医学院附属医院肝胆外科
  • 收稿日期:2023-03-07 出版日期:2024-02-01
  • 通信作者: 任勇军
  • 基金资助:
    硕士、博士学位授权点建设和"一流学科"建设专项(22SXQT0357)

Research progress on tumor markers in primary hepatocellular carcinoma

Fei Wan1, Yongjun Ren2,()   

  1. 1. Department of Radiology, Affiliated Hospital to Chuanbei Medical College, Nanchong 637000, China
    2. Department of Radiology Hepatobiliary Surgery, Affiliated Hospital to Chuanbei Medical College, Nanchong 637000, China
  • Received:2023-03-07 Published:2024-02-01
  • Corresponding author: Yongjun Ren
引用本文:

万菲, 任勇军. 原发性肝细胞癌肿瘤标志物研究进展[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(01): 77-81.

Fei Wan, Yongjun Ren. Research progress on tumor markers in primary hepatocellular carcinoma[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(01): 77-81.

肝癌是造成世界癌症负担的一个主要因素,近几十年来,许多国家的发病率都有所上升,肝癌的病理类型主要为肝细胞癌(HCC),是绝大多数肝癌诊断和死亡的原因。本文主要对于原发性HCC肿瘤标志物甲胎蛋白、异常凝血酶原、甲胎蛋白异质体-3比率、循环DNA、高尔基蛋白-73、骨桥蛋白、磷脂酰肌醇蛋白多糖-3对HCC致癌机制、检测疗效、其相关治疗靶点、切除术后生存、复发率及相关GALAD模型研究进展进行综合论述。

Liver cancer is a major cause of cancer burden in the world. In recent decades, the incidence rate of many countries has increased. The pathological type of liver cancer is mainly hepatocellular carcinoma (HCC), which is the cause of diagnosis and death of most liver cancers. This article is mainly about the carcinogenic mechanism of primary HCC tumor markers alpha-fetoprotein (AFP), abnormal prothrombin (DCP), alpha-fetoprotein heterogene-3 ratio (AFP-L3%), circulating DNA (cfDNA/ctDNA, circulating free DNA), Golgi protein 73 (GP-73), osteopontin (OPN), phosphatidylinositol protein polysaccharide 3 (glycan-3), detection of therapeutic efficacy, related therapeutic targets, survival rate, recurrence rate and related research progress of GALAD model after resection.

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