探讨老年代偿期肝硬化患者膳食炎症指数（DII）、营养参数与衰弱发生风险的相关性，为临床早期干预提供参考。

回顾性选取2023年1月至2025年1月邢台市人民医院肝病科与消化内科收治的120例老年代偿期肝硬化患者为研究对象，依据Fried衰弱量表分为衰弱组（Fried衰弱量表评分≥3分，n=42）与非衰弱组（Fried衰弱量表评分0~2分，n=78）。比较两组患者的DII、营养参数（总蛋白、白蛋白、前白蛋白）及日均营养摄入（能量、蛋白质、碳水化合物、膳食纤维、多不饱和脂肪酸），采用Spearman秩相关分析法分析老年代偿期肝硬化患者DII、营养参数及营养摄入与衰弱发生风险的相关性。

衰弱组患者的DII分级T1＋T2占比低于非衰弱组，T3占比高于非衰弱组；衰弱组总蛋白、白蛋白、前白蛋白水平均低于非衰弱组（P<0.05）；衰弱组摄入能量、蛋白质、碳水化合物、膳食纤维、多不饱和脂肪酸均低于非衰弱组（P<0.05）。Spearman秩相关分析显示，老年代偿期肝硬化患者DII与衰弱发生风险呈正相关，总蛋白、白蛋白、前白蛋白、摄入能量、蛋白质、碳水化合物、膳食纤维、多不饱和脂肪酸与衰弱发生风险呈负相关（P<0.05）。

DII升高，营养参数水平降低，会显著增加老年代偿期肝硬化患者衰弱风险，临床需针对性监测上述指标并实施抗炎饮食与营养支持干预。

To explore the correlation between dietary inflammation index (DII), nutritional parameters and the risk of frailty in elderly patients with compensated liver cirrhosis, and to provide a reference for early clinical intervention.

A total of 120 elderly patients with compensated liver cirrhosis who were admitted to the department of liver disease and the department of gastroenterology of Xingtai People's Hospital from January 2023 to January 2025 were selected retrospectively as the research subjects, and they were divided into the frail group (Fried frailty scale score ≥3 points, n=42) and the non-frail group (Fried frailty scale score 0-2 points, n=78) based on the Fried frailty scale. DII, nutritional parameters (total protein, albumin, prealbumin) and average daily nutritional intake (energy, protein, carbohydrates, dietary fiber, polyunsaturated fatty acids) of the two groups were compared. The Spearman rank correlation analysis method was used to analyze the correlations between DII, nutritional parameters, nutritional intake and the risk of frailty in elderly patients with compensated liver cirrhosis.

The proportion of T1+T2 in the DII classification of the frailty group was lower than that of the non-frailty group, and the proportion of T3 was higher than that of the non-frailty group, the levels of total protein, albumin and prealbumin in the frailty group were all lower than those in the non-frailty group (P<0.05); the intake of energy, protein, carbohydrates, dietary fiber and polyunsaturated fatty acids in the frail group was all lower than those in the non-frail group (P<0.05). The results of Spearman correlation analysis showed that in elderly patients with compensated liver cirrhosis, DII was positively correlated with the risk of frailty, while total protein, albumin, prealbumin, energy intake, protein, carbohydrates, dietary fiber, and polyunsaturated fatty acids were negatively correlated with the risk of frailty (P<0.05).

Elevated DII levels and reduced nutritional parameters significantly increase the risk of frailty in elderly patients with compensated liver cirrhosis, clinicians should monitor these indicators and implement anti-inflammatory dietary and nutritional support interventions.