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中华消化病与影像杂志(电子版) ›› 2017, Vol. 07 ›› Issue (04) : 183 -187. doi: 10.3877/cma.j.issn.2095-2015.2017.04.008

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循证医学

口服二甲双胍与2型糖尿病患者大肠腺瘤发生风险的荟萃分析与系统评价
尹朝晖1, 王静1,(), 于磊2   
  1. 1. 250031 济南军区总医院内分泌科
    2. 250031 济南,山东省立第三医院CT室
  • 收稿日期:2017-05-28 出版日期:2017-08-01
  • 通信作者: 王静

Oral metformin and the risk of colorectal adenoma: a systematic review and meta-analysis

Zhaohui Yin1, Jing Wang1,(), Lei Yu2   

  1. 1. Department of Endocrinology, General Hospital of Jinan Military Region, Jinan 250031, China
    2. CT Department, the Third Shandong Provincial Hospital, Jinan 250031, China
  • Received:2017-05-28 Published:2017-08-01
  • Corresponding author: Jing Wang
  • About author:
    Corresponding author: Wang Jing, Email:
引用本文:

尹朝晖, 王静, 于磊. 口服二甲双胍与2型糖尿病患者大肠腺瘤发生风险的荟萃分析与系统评价[J/OL]. 中华消化病与影像杂志(电子版), 2017, 07(04): 183-187.

Zhaohui Yin, Jing Wang, Lei Yu. Oral metformin and the risk of colorectal adenoma: a systematic review and meta-analysis[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(04): 183-187.

目的

有相关分析显示口服二甲双胍能降低大肠癌发生风险,但尚不明确是否与大肠腺瘤发生有关,故而通过荟萃分析进一步阐明二者相关性。

方法

检索Pubmed、Embase、the Cochrane Library、中国医学文献数据库中符合纳入标准的所有文献至2017年6月,由2位作者对检索数据进行提取,运用Stata 12.0软件对数据进行统计分析。

结果

共有10篇观察性研究纳入此次荟萃分析,结果显示口服二甲双胍与大肠腺瘤之间关系OR=0.74,95% CI(0.58~0.90),I2=61.9%,P=0.05,亚组分析分为病例对照组和队列研究组,其OR值分别为:OR=1.04,95% CI(0.77~1.31),I2=0,P=0.372,OR=0.66,95% CI(0.49~0.84),I2=65%,P=0.009。

结论

口服二甲双胍能减少大肠腺瘤的发生率。

Objective

Some studies indicate that oral metformin can significantly decrease the risk of colorectal cancer, but it is unclear whether it protects against colorectal adenoma.So we further clarify the correlation between the two factors by means of Meta analysis.

Methods

We searched the control trials meeting the inclusion criteria through the PubMed, EMBase, the Cochrane Library, SinoMed published before June 2017.Two authors independently retrieved the databases and extracted the data.Stata 12.0 software was used to analyze the data.

Results

Ten studies were included in this Meta-analysis.The results indicated that oral metformin could decrease the risk of colorectal adenoma(OR=0.74, 95% CI(0.58-0.90), I2=61.9%, P=0.05). We divided the papers into two subgroups: case-control study and retrospective cohort study, and the results were as follows: OR=1.04, 95% CI(0.77-1.31), I2=0, P=0.372; OR=0.66, 95% CI(0.49-0.84), I2=65%, P=0.009.

Conclusion

Oral metformin can decrease the risk of colorectal adenoma.

表1 纳入荟萃分析的相关数据提取
图1 二甲双胍与大肠腺瘤发病关系的荟萃分析森林图
图2 亚组分析病例对照研究与队列研究中二者相关性的森林图
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