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中华消化病与影像杂志(电子版) ›› 2020, Vol. 10 ›› Issue (02) : 84 -88. doi: 10.3877/cma.j.issn.2095-2015.2020.02.010

所属专题: 文献

综述

环状RNA在胃癌发生发展中的作用
张心蕊1, 戎国栋2, 赵鸿2, 徐婷2, 张燕2, 黄珮珺2, 王芳2, 吴蕾2,()   
  1. 1. 222002 江苏连云港,南京医科大学康达学院临床医学部
    2. 210000 南京医科大学第一附属医院检验学部
  • 收稿日期:2019-07-12 出版日期:2020-04-01
  • 通信作者: 吴蕾
  • 基金资助:
    南京医科大学十三五教育研究课题(YB2017075)

Study on the role of circRNA in gastric carcinogenesis

Xinrui Zhang1, Guodong Rong2, Hong Zhao2, Ting Xu2, Yan Zhang2, Peijun Huang2, Fang Wang2, Lei Wu2,()   

  1. 1. Department of Clinical Medicine, Kangda College of Nanjing Medical University, Lianyungang 222002, China
    2. Cinical Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
  • Received:2019-07-12 Published:2020-04-01
  • Corresponding author: Lei Wu
  • About author:
    Corresponding author: Wu Lei, Email:
引用本文:

张心蕊, 戎国栋, 赵鸿, 徐婷, 张燕, 黄珮珺, 王芳, 吴蕾. 环状RNA在胃癌发生发展中的作用[J]. 中华消化病与影像杂志(电子版), 2020, 10(02): 84-88.

Xinrui Zhang, Guodong Rong, Hong Zhao, Ting Xu, Yan Zhang, Peijun Huang, Fang Wang, Lei Wu. Study on the role of circRNA in gastric carcinogenesis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(02): 84-88.

人们在细胞中发现一种与线性RNA不同的缺少5′帽和3′polyA尾的共价闭合结构,由于其环形特性,具有更高稳定性和保守性,这种RNA被称为环状RNA(circRNA)。它在转录和转录后水平起调节作用,并影响肿瘤的发生发展。本文着重介绍与胃癌密切相关的circRNAs,对这类circRNAs的特异性表达和生物学功能进行总结,讨论其作为胃癌诊断和判断预后的生物学标志物,挖掘潜在的临床应用价值。

关键词: 胃癌, CircRNA

Different from linear RNA, a covalent closed structure lacking 5′ cap and 3′ polyA tail is found in cells.Because of its annular characteristics, it has higher stability and conservatism.This kind of RNA is called circular RNA(circRNA). It plays a regulatory role at the transcriptional and post-transcriptional levels and has an impact on the occurrence and development of tumors.This paper focuses on the summary of the specific expression and biological function of circRNAs, and discusses the potential clinical application as a biomarker or target for the diagnosis, treatment and prognosis of gastric cancer.

表1 CircRNAs在胃癌中的表达情况及功能
CircRNAs 位置 表达 作用机制
circ_SPECC1[24] 组织 下调 竞争结合miR-526b,进而影响KDM4A/YAP1的表达;过表达抑制胃癌细胞增殖与侵袭
circYAP1[25] 组织 下调 竞争结合miR-367-5p,进而影响p27 Kip1的表达;过表达能抑制胃癌细胞增殖与侵袭
circLARP4[26] 组织 下调 竞争结合miR-424,进而影响LATS1的表达;过表达能抑制胃癌细胞增殖与侵袭
circZFR[27] 组织 下调 竞争结合miR-107/miR-130a,进而影响PTEN的表达;过表达能抑制胃癌细胞增殖与促进凋亡
circPSMC3[28] 组织/血浆 下调 竞争结合miR-296-5p,进而影响PTEN的表达;过表达能抑制胃癌细胞增殖
hsa_circ_0006848[29] 组织/血浆 下调 竞争结合miR-329-5p
hsa_circ_0000993[30] 组织 下调 竞争结合miR-214-5p;过表达抑制胃癌细胞增殖、侵袭与转移
has_circ_0001461[31] 组织 下调 竞争结合miR-548g,进而影响RUNX1的表达;过表达能抑制胃癌细胞增殖、侵袭与转移
hsa_circ_0027599[32] 组织 下调 竞争结合miR-101,进而影响PHLDA1的表达;过表达能抑制胃癌细胞增殖与转移
hsa_circ_100269[33] 组织 下调 竞争结合miR-30;过表达抑制胃癌细胞增殖
ciRS-7[34] 组织 上调 竞争结合miR-7,进而影响PTEN/PI3K/AKT通路
circ-DONSON[35] 组织 上调 位于细胞核,能够将核重塑因子复合体NURF招募到SOX4的启动子区域,引起转录激活;干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circRNA_001569[36] 组织 上调 竞争结合miR-145,进而影响NR4A2的表达;干扰表达能抑制胃癌细胞凋亡
circSFMBT2[37] 组织 上调 竞争结合miR-182-5p,进而影响CREB1的表达;干扰表达能抑制胃癌细胞增殖
circHIPK3[38] 组织 上调 竞争结合miR-124/miR-29b
circNF1[39] 组织 上调 竞争结合miR-16,进而影响MAP7/AKT3的表达;干扰表达能抑制胃癌细胞增殖与迁移
circPVT1[40] 组织 上调 竞争结合miR-125;干扰表达能抑制胃癌细胞增殖
circHECTD1[41] 组织 上调 竞争结合miR-1256,进而影响USP5的表达;干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circPDSS1[42] 组织 上调 竞争结合miR-186-5p,进而影响NEK2的表达;干扰表达能抑制胃癌细胞增殖
hsa_circ_0008549[43] 组织 上调 竞争结合miR-136-5p,进而影响WNT2的表达;干扰表达能抑制胃癌细胞增殖、迁移与侵袭
hsa_circ_006100[44] 组织 上调 竞争结合miR-195,进而影响GPRC5A的表达;干扰表达能抑制胃癌细胞增殖
hsa_circ_0092303[45] 组织 上调 竞争结合m iR-331-3p,进而影响TGFBR1的表达;干扰表达能抑制胃癌细胞增殖、迁移与侵袭
表2 CircRNAs在胃癌中的诊断价值
1
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