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中华消化病与影像杂志(电子版) ›› 2022, Vol. 12 ›› Issue (05) : 306 -309. doi: 10.3877/cma.j.issn.2095-2015.2022.05.012

新技术·新方法

早期食管癌的光动力治疗
袁耒1, 邹志强1,(), 李传海1, 刘玉1, 徐瑞鑫1, 杜以营1   
  1. 1. 250031 济南,联勤保障部队第九六〇医院心胸外科
  • 收稿日期:2022-08-19 出版日期:2022-10-01
  • 通信作者: 邹志强
  • 基金资助:
    济南市临床医学科技创新计划(No.202134026)

Photodynamic therapy in patients with early esophageal cancer

Lei Yuan1, Zhiqiang Zou1,(), Chuanhai Li1, Yu Liu1, Ruixin Xu1, Yiying Du1   

  1. 1. Department of Cardiothoracic Surgery, the 960th Hospital of Joint Logistics Support Force, Jinan 250031, China
  • Received:2022-08-19 Published:2022-10-01
  • Corresponding author: Zhiqiang Zou
引用本文:

袁耒, 邹志强, 李传海, 刘玉, 徐瑞鑫, 杜以营. 早期食管癌的光动力治疗[J]. 中华消化病与影像杂志(电子版), 2022, 12(05): 306-309.

Lei Yuan, Zhiqiang Zou, Chuanhai Li, Yu Liu, Ruixin Xu, Yiying Du. Photodynamic therapy in patients with early esophageal cancer[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(05): 306-309.

目的

观察光动力疗法治疗早期食管癌的效果。

方法

回顾分析2020年1月至2021年6月联勤保障部队第九六〇医院住院患者早期食管癌光动力治疗的临床资料,5例患者静脉滴注光敏剂血卟啉注射液(3 mg/kg)后48 h和72 h,以波长630 nm、功率密度200 mW/cm2半导体激光照射病灶,照射时间800~1000 s,能量密度160~200 J/cm2。术后3、6、12个月胃镜观察并病理活检。

结果

1~2疗程光动力治疗后经过1年随访,患者获得完全缓解,无严重不良反应发生。

结论

光动力治疗早期食管癌疗效确切、安全、微创、不良反应少。

Objective

To assess the short-term efficacy of photodynamic therapy in the treatment of early esophageal cancer.

Methods

The clinical data of inpatients with early esophageal cancer treated by photodynamic therapy in the 960th Hospital of Joint Logistic Support Force from January 2020 to June 2021 were retrospectively analyzed.At 48 h and 72 h after intravenous injection of photosensitizer hematoporphyrin injection(3 mg/kg), the lesions of 5 patients were irradiated with a semiconductor laser with a wavelength of 630 nm and a power density of 200 mW/cm2.The irradiation time was 800-1000 s, and the energy density was 160-200 J/cm2.Gastroscopy and pathological biopsy were performed at 3, 6 and 12 months after operation.

Results

After 1-2 courses of photodynamic therapy, the patients achieved complete remission with no serious adverse reactions after 1 year of follow-up.

Conclusion

Photodynamic therapy for early esophageal cancer is effective, safe, minimally invasive and has few adverse reactions.

表1 早期食管癌患者一般情况
图6 食管癌光动力治疗后12个月胃镜下卢戈液染色:未见黏膜碘染色缺失,于治疗后形成的瘢痕处取活检,病理未见肿瘤复发或不典型增生
表2 早期食管癌患者光动力治疗后不良反应及随访情况
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