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中华消化病与影像杂志(电子版) ›› 2024, Vol. 14 ›› Issue (01) : 21 -27. doi: 10.3877/cma.j.issn.2095-2015.2024.01.004

论著

多层螺旋CT增强扫描对伴有肝转移的胃肝样腺癌的诊断价值
尤亚茹1, 刘译阳1, 李莉明1, 赵帅1, 袁梦晨1, 黄清博1, 高剑波1,()   
  1. 1. 450052 郑州大学第一附属医院放射科
  • 收稿日期:2023-02-28 出版日期:2024-02-01
  • 通信作者: 高剑波
  • 基金资助:
    国家自然科学基金(81971615)

Value of MSCT enhanced scanning in the diagnosis of gastric hepatoid adenocarcinoma with liver metastasis

Yaru You1, Yiyang Liu1, Liming Li1, Shuai Zhao1, Mengchen Yuan1, Qingbo Huang1, Jianbo Gao1,()   

  1. 1. Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2023-02-28 Published:2024-02-01
  • Corresponding author: Jianbo Gao
引用本文:

尤亚茹, 刘译阳, 李莉明, 赵帅, 袁梦晨, 黄清博, 高剑波. 多层螺旋CT增强扫描对伴有肝转移的胃肝样腺癌的诊断价值[J]. 中华消化病与影像杂志(电子版), 2024, 14(01): 21-27.

Yaru You, Yiyang Liu, Liming Li, Shuai Zhao, Mengchen Yuan, Qingbo Huang, Jianbo Gao. Value of MSCT enhanced scanning in the diagnosis of gastric hepatoid adenocarcinoma with liver metastasis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(01): 21-27.

目的

探讨伴有肝转移的胃肝样腺癌(HAS)患者的增强多层螺旋CT(MSCT)特征。

方法

回顾性分析2013年2月至2022年2月在郑州大学第一附属医院经病理确诊的8例HAS患者,8例患者均行腹部增强CT扫描,其中4例为术前(胃癌根治术)检查。男6例,女2例,中位年龄64岁。分析病灶影像学参数,包括动脉和静脉期的增强模式、坏死情况、静脉是否有血栓以及整体影像学诊断。

结果

胃部病灶位于胃底和贲门4例(4/8,50%)、胃窦3例(3/8,37.5%)、胃底1例(1/8,12.5%)。分析4例术前胃部病灶图像,胃壁最大厚度为(22.02±3.64)mm,大体类型表现为隆起型2例、溃疡型1例、浸润型1例。肿瘤平扫呈软组织密度肿块,2例见低密度坏死区,4例均未见钙化。动脉期3例明显强化,1例中度强化。2例可见由于瘤内坏死引起的不均匀强化。8例HAS肝转移灶中6例为多发,2例为单发。轴位MSCT示7例患者最大肝转移癌灶>3 cm,且无论大小均可见坏死。6例癌灶边界清楚。增强强化不均匀,3例表现为环形强化。动脉期轻度强化6例,中度强化2例,呈典型"快进快出"模式。7例伴淋巴结转移,3例伴门脉侵犯,1例伴胰腺转移。

结论

胃部原发癌灶MSCT典型表现为胃壁增厚>2 cm的软组织密度肿块,可伴有坏死,罕见钙化,增强扫描见中度至明显持续性强化。肝转移灶增强MSCT表现类似于原发性肝癌,但是患者常无肝癌易患因素,且瘤灶坏死率高。此外,常合并腹腔内、胃周淋巴结肿大,部分可合并腹部其他器官如胰腺转移。

Objective

To investigate the enhanced multislice spiral CT (MSCT) features of hepatoid adenocarcinoma of the stomach (HAS) with liver metastasis.

Methods

Eight cases of histologically proven HAS between February 2013 and February 2022 in The First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. All 8 patients underwent contrast-enhanced abdominal CT scanning, of which 4 were preoperative radical gastrectomy. There were 6 males and 2 females, with a median age of 64 years. Imaging parameters were analyzed, including enhancement mode of arterial and venous phases, necrosis, venous thrombosis and overall imaging diagnosis.

Results

The gastric lesions were located in the fundus of stomach and cardia (4/8, 50%), antrum of stomach (3/8, 37.5%) and fundus of stomach (1/8, 12.5%). Preoperative images of 4 gastric lesions were analyzed. The maximum thickness of gastric wall was (22.02±3.64) mm, and the general types were protuberance type in 2 cases, ulcer type in 1 case and infiltration type in 1 case. The tumor showed soft tissue density mass on plain scan, and 2 cases showed low density necrosis area. No calcification was found. In arterial phase, 3 cases showed obvious enhancement, 1 case showed moderate enhancement, and 2 cases showed uneven enhancement due to intra-tumor necrosis. Among the 8 cases of HAS liver metastases, 6 cases were multiple, and 2 cases were single. Axial MSCT showed that the largest liver metastases in 7 patients were > 3 cm, and necrosis was visible regardless of size. The boundaries of the cancer lesions were clear in 6 cases. The reinforcement was uneven, and 3 cases showed ring reinforcement. There were 6 cases of mild reinforcement in the arterial phase and 2 cases of moderate intensification, typical "fast forward and fast out" mode. There were 7 cases with lymph node metastasis, 3 cases with portal vein invasion and 1 case with pancreatic metastasis.

Conclusion

The typical MSCT manifestation of primary gastric cancer is a soft tissue density mass with gastric wall thickening >2 cm, which may be accompanied by necrosis and rare calcification. Enhanced scanning shows moderate to obvious continuous enhancement. The enhanced MSCT findings of liver metastases are similar to primary liver cancer (HCC), but patients often have no risk factors for HCC, and the tumor necrosis rate is high. It is often complicated with lymph node enlargement in abdominal cavity and around stomach, and some of them may be complicated with other abdominal organs such as pancreatic metastasis.

表1 胃肝样腺癌伴肝转移患者的临床资料
图1 62岁女性患者胃原发癌灶CT表现注:1A平扫轴位MSCT示胃贲门部软组织密度肿块(箭头),胃壁最大厚度约22 mm,CT平均值约40 HU;1B增强动脉期明显强化,CT平均值约89 HU;1C静脉期强化程度未见显著减低,CT平均值约80 HU。
图2 66岁男性患者胃原发癌灶及肝转移灶CT表现注:胃原发癌灶(白箭)。2A平扫轴位MSCT示贲门部软组织密度肿物,胃壁最大厚度约29 mm,CT平均值约41 HU;2B增强动脉期明显强化,CT平均值约86 HU;2C静脉期持续强化,CT平均值约77 HU;2D冠状面重建CT图像显示一个大的突起肿块并伴有中央溃疡。肝转移灶(白星)。2A平扫轴位MSCT示肝右叶示单发巨大转移性肝占位;2B动脉期可见轻度不均匀强化;2C静脉期强化程度减低,中央可见不强化坏死区。
图3 75岁男性患者胃原发癌灶CT表现注:3A平扫轴位MSCT示胃壁弥漫性增厚;3B增强动脉期呈双层样,内层高密度,外层为低密度(箭头);3C门静脉癌栓显示为主干轻度强化充盈缺损灶(箭头);3D肝门区及腹膜后广泛转移增大淋巴结,内伴坏死(箭头)。
表2 胃原发癌灶的增强多层螺旋CT特征
图4 75岁男性患者多发肝转移灶CT表现注:4A平扫轴位MSCT示肝内多发稍低密度转移灶(箭头),边界尚清;4B增强动脉期可见轻度不均匀强化;4C静脉期强化程度下降,明显低于正常肝实质。
图5 65岁男性患者胃癌根治术后1年复查CT注:5A为平扫期轴位图像,胰头部位示软组织密度肿块;肝右叶多发低密度转移灶,边界欠清。5B和5C分别为增强动脉期、静脉期图像,示胰头肿块轻中度不均匀强化,内见坏死区,静脉期强化程度减低。肝脏转移灶强化模式与肿块相似。5D为MPR冠状面重建图像,可更加清楚显示栓子形态。胰头病灶(白箭);肝转移灶(红箭);门脉栓子(黄箭)。
表3 肝转移灶的增强多层螺旋CT特征
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