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中华消化病与影像杂志(电子版) ›› 2023, Vol. 13 ›› Issue (02) : 93 -99. doi: 10.3877/cma.j.issn.2095-2015.2023.02.007

循证医学

2012-2021年粪菌移植研究的趋势及热点分析
廖想1, 李爽2,(), 曾瑶1   
  1. 1. 618000 四川省,德阳市人民医院消化内科
    2. 618000 四川省,德阳市人民医院全科医学科
  • 收稿日期:2022-12-30 出版日期:2023-04-01
  • 通信作者: 李爽

Analysis of research trends and hotspots of fecal microbiota transplantation from 2012 to 2021

Xiang Liao1, Shuang Li2,(), Yao Zeng1   

  1. 1. Department of Gastroenterology, Deyang People′s Hospital, Deyang 618000, China
    2. Department General Practice, Deyang People′s Hospital, Deyang 618000, China
  • Received:2022-12-30 Published:2023-04-01
  • Corresponding author: Shuang Li
引用本文:

廖想, 李爽, 曾瑶. 2012-2021年粪菌移植研究的趋势及热点分析[J/OL]. 中华消化病与影像杂志(电子版), 2023, 13(02): 93-99.

Xiang Liao, Shuang Li, Yao Zeng. Analysis of research trends and hotspots of fecal microbiota transplantation from 2012 to 2021[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(02): 93-99.

目的

利用文献计量学方法对Web of Science核心集中主题为粪菌移植相关文章进行分析,以期为未来该领域研究提供借鉴。

方法

通过检索Web of Science核心集数据库,获取2012年1月1日至2021年12月31日期间粪菌移植文献的相关信息。用VOSviewer 1.6.17软件对纳入研究文献的被引频次、时间、作者和关键词等进行提取,并生成高产作者的合作网络图和高频关键词的聚类网络图。

结果

通过主题词检索共得到文献3588篇,近十年粪菌移植文献总体呈逐步上升趋势。发表粪菌移植文献最多的国家为美国,其次为中国,德国排在第三位。被引频次最多的文献于2018年发表,被引频次为1848次。研究发文数量>10篇的机构共有173个,形成了10个高产作者合作群。

结论

粪菌移植研究的主题聚类可归纳为动物实验、治疗机制、有效性及安全性、肠道感染的治疗等。

Objective

To analyze the articles related to fecal microbiota transplantation in Web of Science Core Collection using bibliometric methods, in order to provide reference for future research in this field.

Methods

The relevant information of literature of fecal microbiota transplantation from January 1, 2012 to December 31, 2021 was obtained by searching the Web of Science Core Collection. VOSviewer 1.6.17 was used to extract the cited frequency, publication time, authors and keywords from the included studies, and to generate the cooperation network diagram of high-yield authors and the cluster network diagram of high-frequency keywords.

Results

A total of 3588 documents were obtained through subject word search. The literature on fecal microbiota transplantation showed a gradual upward trend of publication in recent ten years. The country with the most published literature was the United States, followed by China, and Germany. The most frequently cited literature was published in 2018, with a frequency of 1848 citations. There were 173 organizations with more than 10 studies published by the main authors of the study, forming 10 high-yield author cooperation groups.

Conclusion

The hot topics of fecal microbiota transplantation research can be summarized as animal experiment, treatment mechanism, effectiveness and safety, treatment of intestinal infection.

图1 2012至2021年粪菌移植文献数量分布
表1 粪菌移植研究发文数量前十国家
图2 粪菌移植关键词共现分析
表2 被引频次前十的粪菌移植文献情况
序号 被引频次 年份 题目 第一作者 期刊 影响因子(2021)
1 1848 2018 Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors Routy SCIENCE 63.714
2 1450 2015 Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota Vetizou SCIENCE 63.714
3 1226 2018 Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) McDonald CLINICAL INFECTIOUS DISEASES 20.999
4 1019 2016 The gut microbiota and host health: a new clinical frontier Marchesi GUT 31.793
5 764 2014 European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection Debast CLINICAL MICROBIOLOGY AND INFECTION 13.31
6 738 2015 Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial Moayyedi GASTROENTEROLOGY 33.883
7 717 2016 Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism Zheng MOLECULAR PSYCHIATRY 13.437
8 571 2016 Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat Kelly JOURNAL OF PSYCHIATRIC RESEARCH 5.25
9 568 2014 Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis Thaiss Cell 66.85
10 559 2013 Fecal Microbiota Transplantation for Clostridium difficile Infection:Systematic Review and Meta-Analysis Kassam AMERICAN JOURNAL OF GASTROENTEROLOGY 12.045
表3 2012年1月1日至2021年12月31日粪菌移植文献关键词聚类主题
表4 2012年1月1日至2021年12月31日粪菌移植研究前20位高频关键词
图3 粪菌移植相关文章作者及其合作情况
图4 发表粪菌移植文章的相关机构及其合作情况
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