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中华消化病与影像杂志(电子版) ›› 2023, Vol. 13 ›› Issue (03) : 129 -134. doi: 10.3877/cma.j.issn.2095-2015.2023.03.001

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从炎症性肠病治疗策略转变看生物制剂应用进展
余佳丽, 江学良()   
  1. 250001 济南,山东中医药大学
    250001 济南,山东中医药大学第二附属医院消化中心
  • 收稿日期:2022-12-06 出版日期:2023-06-01
  • 通信作者: 江学良
  • 基金资助:
    山东省医学会脐带血科研专项基金项目(YXH2020ZX007)

Application progress of biological agents from the perspective of therapeutic strategy transformation of inflammatory bowel disease

Jiali Yu, Xueliang Jiang()   

  1. Shandong University of Traditional Chinese Medicine, Jinan 250001, China
    Digestive Center, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China
  • Received:2022-12-06 Published:2023-06-01
  • Corresponding author: Xueliang Jiang
引用本文:

余佳丽, 江学良. 从炎症性肠病治疗策略转变看生物制剂应用进展[J]. 中华消化病与影像杂志(电子版), 2023, 13(03): 129-134.

Jiali Yu, Xueliang Jiang. Application progress of biological agents from the perspective of therapeutic strategy transformation of inflammatory bowel disease[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(03): 129-134.

炎症性肠病治疗策略已从传统的"升阶梯"逐渐转为"降阶梯"治疗。国内外指南一致推荐在炎症性肠病早期使用以TNF-α抑制剂为代表的生物制剂,而且大量临床研究也证实这种"降阶梯"疗法的疗效和安全性。以阿达木单抗和英夫利西单抗为主的国产生物类似药上市降低了我国患者的治疗成本,并提高了患者的治疗依从性。

The treatment strategy of inflammatory bowel disease has gradually changed from traditional "ascending ladder" to "descending ladder". Domestic and foreign guidelines unanimously recommend the use of biologics represented by TNF-αinhibitors in the early stage of inflammatory bowel disease, and a large number of clinical studies have also confirmed the efficacy and safety of this "descending ladder" therapy.The listing of domestic biological analogues dominated by adalimumab and infliximab has reduced the treatment cost and improved the treatment compliance of patients in China.

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