Abstract:
Objective To analyze the incidence and related factors of biliary nephropathy in patients with severe liver disease.
Methods The renal pathological findings of 49 patients with severe liver disease in Second People′s Hospital of Ordos from 2007 to 2016 were analyzed retrospectively.The relationship between the incidence of biliary nephropathy and different types of severe liver diseases and its relationship with bilirubin and renal function were analyzed.
Results The incidences of biliary nephropathy in acute hepatic failure group, subacute liver failure group, chronic hepatic failure group, acute on chronic liver failure group and decompensated cirrhosis group were 0, 16.7%, 46.2%, 66.7% and 20.0% respectively.The incidence of biliary nephropathy was significantly correlated with the type of severe liver disease(χ2=9.37, P<0.05). With the increase of bilirubin, the incidence of biliary nephropathy increased gradually(χ2=19.05, P<0.01). The renal function of patients with biliary nephropathy was significantly poorer than that of patients without biliary nephropathy [urea nitrogen: (16.3±7.6)mmol/L vs.(8.7±5.4)mmol/L, t=4.67, P<0.05; creatinine: (237.5±9.7)μmol/L vs.(118.4±17.8)μmol/L, t=2.35, P<0.05).
Conclusions The incidence of biliary nephropathy is closely related to the type of severe liver disease, the length of disease, the degree of jaundice and the damage of renal function.
Key words:
Severe liver disease,
Biliary nephropathy,
Relevance
Yongli Pang, Pengjuan Hu, Xiaochuan Li, Xiaoling Bai, Mingjun Tan, Meidong Zhang. Study on the incidence and clinical relevance of biliary nephropathy in patients with severe liver disease[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(05): 196-199.