To compare the efficacy of oral solution of magnesium sodium potassium sulfate and polyethylene glycol electrolyte powder on intestinal cleansing during colonoscopy.

A total of 200 patients in Bozhou People′s Hospital requiring colonoscopy from January 1, 2022 to January 1, 2023 were selected.According to random number table method, all patients were randomly divided into observation group(oral solution of magnesium sodium potassium sulfate)and control group(polyethylene glycol electrolyte powder). The success rate of intestinal preparation, the Boston bowel preparation scale(BBPS)of the whole colon and all parts of the intestine, patient satisfaction, the proportion of patients willing to re-use this drug and the safety of the two groups were analyzed respectively.

The BBPS scores of the whole colon and each segment of colon in the observation group and the control group showed 7.8±1.4 vs.7.4±1.3 in the whole colon, 2.6±0.5 vs.2.3±0.5 in the right colon, 2.7±0.5 vs.2.5±0.6 in the transverse colon, 2.7±0.5 vs.2.3±0.6 in the left colon, with statistically significant differences(P<0.05).98% of the observation group and 91% of the control group had intestinal preparation score≥6(P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the patients in the observation group who were willing to choose the intestinal cleanser again were more than the control group(P<0.05).

The oral solution of magnesium sodium potassium sulfate is better than polyethylene glycol electrolyte powder in the effects of intestinal preparation, which is easy to be accepted by patients.

To evaluate the clinical efficacy of bevacizumab and anlotinib combined with oxaliplatin in the treatment of advanced rectal cancer.

A retrospective analysis was conducted on 88 patients with advanced rectal cancer admitted from January 2019 to January 2021.Patients were categorized into two groups based on their treatment regimens: the control group(treated with bevacizumab combined with oxaliplatin, n=47)and the observation group(treated with anlotinib combined with oxaliplatin, n=41). Clinical efficacy after treatment, serum tumor markers(CEA and CA19-9)levels, quality of life, and adverse reaction incidence were compared between the two groups.Both groups were also followed up for 2 years to observe survival status.

After treatment, the objective response rate(ORR)of the observation group was 46.34%, and the disease control rate(DCR)was 78.05%, both significantly higher than those of the control group(ORR 25.53% and DCR 57.45%, P<0.05). After treatment, serum tumor markers CEA and CA19-9 both showed significant improvement, and the improvement in the observation group was significantly better than that in the control group(P<0.001). During the 2-year follow-up period, the median progression-free survival(PFS)of the observation group was(19.88±5.12)months, significantly longer than that of the control group, which was(16.91±6.06)months(P<0.05). In terms of quality of life, the scores of physical condition, family/social situation, emotional state, functional status, and additional concerns in the observation group were all significantly higher than those in the control group(P<0.05). Moreover, there was no significantly significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).

Anlotinib combined with oxaliplatin demonstrates greater clinical efficacy for treating advanced rectal cancer than bevacizumab combined with oxaliplatin, which can further prolong the median PFS of patients and improve their quality of life.

To investigate the clinical efficacy of Jiawei Lizhong Decoction combined with mesalazine in the treatment of mild active Crohn′s disease.

A total of 100 patients with mild active Crohn′s disease admitted to Daqing Traditional Chinese Medicine Hospital from January 2019 to January 2022 were included, and all patients were divided into a control group(n=50)and observation group(n=50)according to the randomized alphabetical method.The control group was treated with mesalazine, and the experimental group was treated with Jiawei Lizhong Decoction on top of the treatment in the control group.The Chinese medicine evidence score, Crohn′s disease activity index(CDAI)score and Crohn′s disease endoscopic index of severity(CDEIS)score, inflammatory factors(IL-6, TNF-α)levels, immune function indexes(serum CD3+, CD4+, CD4+ /CD8+ ), and incidence of adverse reactions were compared before and after treatment in the two groups.

There were no statistically significant differences the general baseline informations(gender, age, BMI, disease duration)between the control and observation groups(P>0.05), The overall effective rate of the observation group was higher than that of the control group, (P<0.05). After treatment, the CDAI and CDEIS scores of patients in both groups decreased, and the experimental group was lower than the control group(P<0.05). There was no statistically significant difference inthe total incidence of adverse reactions between the two groups(P>0.05).

Jiawei Lizhong Decoction combined with mesalazine is effective in treatment of mild active Crohn′s disease, which can effectively relieve the clinical symptoms and reduce the inflammatory response in patients with mild active Crohn′s diseas

To investigate the efficacy of rabeprazole combined with Kangfuxin solution in the treatment of duodenal ulcer with Helicobacter pylori(Hp)infection.

A total of 126 duodenal ulcer patients with Hp infection who were treated in Linquan County People′s Hospital from April 2019 to February 2023 were selected as the research objects.All patients were randomly divided into control group(63 cases)and observation group(63 cases)by digital random table method.The control group was treated with rabeprazole triple therapy, and the observation group was treated with Kangfuxin solution on the basis of the control group.The clinical efficacy, Hp eradication rate, ulcer healing time, clinical symptom score, oxidative stress indicators(MDA, SOD, GSH-Px)levels, serum inflammatory factors(NF-κB, HMGB1, TNF-α)levels and the incidence of adverse reactions were compared between the two treatment schemes.

The total effective rate and Hp eradication rate of rabeprazole combined with Kangfuxin solution in the treatment of Hp infection positive duodenal ulcer were significantly higher than those of rabeprazole triple therapy(P<0.05). After treatment, the clinical symptom scores, MDA levels and serum inflammatory factors levels of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group(P<0.05). The levels of SOD and GSH-Px in the observation group were significantly higher than those in the control group(P<0.05). The total incidence of adverse reactions such as loss of appetite, dizziness and insomnia in the observation group was slightly lower than that in the control group, but there was no significant difference(P>0.05).

Rabeprazole combined with Kangfuxin solution can effectively reduce oxidative stress response and body inflammation in patients with duodenal ulcer with Hp infection, improve clinical symptoms and clinical efficacy.

To investigate the current situation and influencing factors of family medication used by guardians of children with diarrhea to provide more reference for early identification of risk groups and more active and effective pharmaceutical intervention.

The guardians of children with diarrhea received medicine from the pharmacy of Jinan Second Maternal and Child Health Hospital were investigated on the status of family medication in the period from January 2023 to March 2023 and the questionnaire knowledge, behavior and attitude scores were recorded.The univariate and multivariate methods were used to evaluate the influencing factors of family medication of guardians of children with diarrhea.

The scores of knowledge, attitude and behavior of 593 guardians of children with diarrhea were(8.41±1.75)points, (23.86±5.44)points and(22.07±4.87)points of family medication survey, respectively and the proportions of failure were 60.88%(361/593), 9.11%(54/593)and 86.00%(510/593), respectively.Univariate analysis showed that personal monthly income, household registration type, education level and job occupation may be related to the knowledge level of family medication of guardians of children with diarrhea(P<0.05). Job occupation may be related to family medication attitude and behavior level of guardians of children with diarrhea(P<0.05). The results of multivariate linear regression model showed that job occupation was an independent factor influencing the level of family medication knowledge, attitude and behavior of guardians of children with diarrhea(P<0.05).

The level of family medication knowledge and practice of guardians of children with diarrhea is low and the occupation type of guardians can independently influence the level of family medication knowledge and practice.

To investigate the effect of low-dose celecoxib on postoperative recurrence of colorectal adenomas.

A total of 213 patients admitted to the Department of Gastroenterology of Bozhou People′s Hospital from January 1, 2020 to March 1, 2022 due to colon polyps underwent endoscopic polypectomy with postoperative pathological manifestations of adenomatous polyps were included, and were randomly divided into observation group (108 cases) and control group (105 cases). The observation group was given low-dose celecoxib 200 mg, once a day. The control group was given the same dose placebo. Both groups were followed up for half of 1 year and 1 year. The recurrence rates and the incidences of adverse reactions (gastrointestinal bleeding, gastroduodenal ulcer and death) of the two groups were analyzed.

Half a year later, the recurrence rate of adenoma in the observation group (2/108) was lower than that in the control group (8/105); One year later, the recurrence rate of adenoma in the observation group (9/108) was still lower than that in the control group (23/105), with statistically significant differences (P<0.05). The incidence of adverse reactions in the observation group (2/108) was slightly higher than that in the control group (0/105) after six months of follow-up, without a statistically significant difference (P>0.05). The incidence of adverse reactions in the observation group (8/108) was higher than that in the control group (2/105) after one year of follow-up, with a statistically significant difference (P<0.05).

Oral low-dose celecoxib can effectively prevent the occurrence of colorectal adenomas, but the incidence of adverse reactions will increase with prolonged oral administration.

To analyze the diagnostic efficacy of contrast-enhanced ultrasound(CEUS)and upper abdominal enhanced magnetic resonance(MRI)scanning in patients with hepatic hemangioma.

A total of 86 patients with hepatic hemangioma admitted from January 2021 to October 2022 were selected as subjects.The surgical pathology results of patients were used as the diagnostic gold standard to compare the diagnostic efficacy of CEUS and enhanced upper abdominal MRI plain scan for hepatic hemangioma.

Among the 86 patients with hepatic hemangioma, 80 cases met by CEUS, with a diagnostic coincidence rate of 93.02%; 75 cases met by upper abdominal enhanced magnetic resonance scanning, with a diagnostic coincidence rate of 87.21%.There was no significant difference in diagnostic coincidence rate between contrast-enhanced ultrasound and upper abdominal enhanced magnetic resonance scanning(93.02% vs.87.21%, P>0.05). The positive rate of CEUS and upper abdominal enhanced magnetic resonance scanning for hepatic hemangioma with≥4 mm diameter was 90.91%(30/33)and 100.00%(33/33)respectively, with no statistically significant difference(P>0.05). The positive rates of CEUS and upper abdominal enhanced magnetic resonance scanning for hepatic hemangioma with<4 mm diameter were 94.34%(50/53)and 79.25%(42/53)respectively.The positive rate of CEUS was higher than that of upper abdominal enhanced magnetic resonance scanning(P<0.05). CEUS: The arterial stage showed spot-like and nodular centripetal enhancement without central enhancement; the portal stage showed centripetal filling, the lesion echo increased compared to the surrounding tissue; the delayed stage showed slow filling compared to the surrounding liver parenchyma.Upper abdominal enhanced magnetic resonance scanning: low density mass shadow could be seen in the liver of the patient, and the external surface of the lesion was smooth.Compared with T1, T2 and ADC images, it was found that the scope of tumor enhancement in venous stage was enlarged and expanded, and the remaining two phases showed nodular enhancement.

Both CEUS and contrast-enhanced magnetic resonance scanning have good diagnostic efficacy in the diagnosis of hepatic hemangioma patients, but CEUS has a relatively higher detection rate in small-diameter hepatic hemangioma.CEUS and contrast-enhanced magnetic resonance scanning in the upper abdomen can be used in the diagnosis of hepatic hemangioma clinically, which is conducive to increasing the diagnostic accuracy of hepatic hemangioma disease.

To analyze the diagnostic value of platelet-albumin-bilirubin(PALBI)score in liver cirrhosis complicated with upper gastrointestinal bleeding and the severity of the disease.

One hundred and fifty patients with liver cirrhosis treated in Hainan Cancer Hospital from January 2020 to December 2022 were selected and divided into bleeding group and non-bleeding group, with 75 cases in each group.According to the severity of the disease, the bleeding group was divided into mild bleeding group, moderate bleeding group and severe bleeding group, with 25 cases in each group.Child-Pugh grade, PALBI score and shock index of patients with bleeding were calculated.Spearman correlation test was used to analyze the correlations between PALBI score and Child-Pugh grade and shock index.The receiver operating characteristic(ROC)curve was used to analyze the value of PALBI score in the diagnosis of liver cirrhosis complicated with upper gastrointestinal bleeding and the severity of the disease.

In patients with liver cirrhosis, the PALBI score in the bleeding group was significantly higher than that in the non-bleeding group(P<0.01). The PALBI score in the severe bleeding group was significantly higher than that in the moderate bleeding group(P<0.01), and the PALBI score in the moderate bleeding group was significantly higher than that in the mild bleeding group(P<0.01). PALBI score was positively correlated with Child-Pugh grade and shock index(P<0.05). The area under the ROC curve of liver cirrhosis with upper gastrointestinal bleeding predicted by PALBI score was 0.802, the area under the ROC curve of mild and moderate bleeding was 0.907, and the area under the ROC curve of moderate and severe bleeding was 0.826.

PALBI score is effective in predicting upper gastrointestinal bleeding and diagnosing the severity of upper gastrointestinal bleeding in patients with liver cirrhosis.

To analyze the clinical value of three-dimensional arterial spin labeling(3D-ASL)combined with dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)in the diagnosis of recurrence of glioma and radiation brain necrosis.

Retrospective study was conducted on the clinical data of 60 patients with glioma who received postoperative adjuvant radiotherapy in Zhuozhou City Hospital from January 2019 to December 2021.The new abnormal enhancement lesions were found by routine MRI examination, and they were divided into postoperative recurrence group of glioma(n=38)and radiation brain necrosis group(n=22)after confirmed by secondary surgical pathology.The patients in both groups received MRI, 3D-ASL and DCE-MRI to obtain the quantitative parameters of 3D-ASL and DCE-MRI.The parameters of the two groups were compared and the clinical value of 3D-ASL combined with DCE-MRI in the diagnosis of postoperative recurrence and radiation brain necrosis of glioma was analyzed.

The rCBF and Ktrans values of glioma recurrence group were higher than those of radiation brain necrosis group(P<0.05). The accuracy of 3D-ASL combined with DCE-MRI was higher than that of single examination(P<0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 3D-ASL combined with DCE-MRI were higher than those of single examination(P<0.05).

3D-ASL combined with DCE-MRI can be used clinically to distinguish the recurrence of brain glioma from radiation brain necrosis.The combined examination of the two has extremely high diagnostic value and can improve the diagnostic accuracy.

To investigate the correlations between serum levels of suppressor of cytokine signaling-3(SOCS3), liver X receptorα(LXRα)and CT imaging features in patients with non-alcoholic fatty liver disease(NAFLD).

Ninety NAFLD patients who underwent CT examination in Affiliated Hospital of Inner Mongolia Medical University from March 2019 to March 2022 were collected as the study group.The patients in study group were divided into mild group, moderate groupand severe group based on CT imaging results.Additionally, 90 healthy individuals in the same period were collected as the control group.Enzyme-linked immunosorbent assay was applied to detect serum levels of SOCS3 and LXRα.The liver fat content(Fat%QI), subcutaneous fat area(SAA), visceral fat area(VAA), total fat area(TAA)and skeletal muscle area(SMA)in the two groups were measured by CT, the visceral fat/subcutaneous fat(V/S)and visceral fat area/total fat area(V/T)were calculated, and liver/spleen CT values were detected.Pearson′s method was applied to analyze the correlation between serum SOCS3 and LXRα, and their correlations with CT parameter related indicators.

The serum SOCS3 level in the mild, moderateand severe groups was significantly lower than that in the control group(P<0.05), and the LXRαlevel was significantly higher than that in the control group(P<0.05). The serum SOCS3 level in the moderate and severe groups was significantly lower than that in the mild group(P<0.05), and the LXRαlevel was significantly higher than that in the mild group(P<0.05). The CT value of the study group was lower than that of the control group(P<0.05), while the Fat%QI, SAA, VAA, TAA, SMA, V/Sand V/T were significantly higher than those of the control group(P<0.05). The CT value of the mild, moderateand severe groups decreased significantly in sequence(P<0.05), while the values of Fat%QI, SAA, VAA, TAA, SMA, V/Sand V/T increased significantly in sequence(P<0.05). Pearson correlation showed that SOCS3 was negatively correlated with LXRα(P<0.05), while Fat%QI, SAA, VAA, TAA, SMA, V/S, V/T were significantly negatively correlated with SOCS3, and positively correlated with LXRα(P<0.05). The CT value showed a significant positive correlation with SOCS3 and a significant negative correlation with LXRα(P<0.05).

Serum SOCS3 level decreases and LXRαlevel increases in NAFLD patients, both are closely related to CT imaging features.

To investigate the critical complications in patients with malignant biliary obstruction after biliary stent implantation and analyze the risk factors.

A total of 77 patients with malignant biliary obstruction undergoing percutaneous transhepatic biliary stent implantation at Sir Run Run Shaw Hospital of Zhejiang University School of Medicine from January 2015 to August 2019 and 69 patients with malignant biliary obstruction undergoing endoscopic biliary stent implantation in the Second Affiliated Hospital of Zhejiang University School of Medicine from August 2016 to September 2021 were retrospectively analyzed.They were divided into critical complications groups and non-critical complications groups according to whether critical complications occurred within 1 month after surgery.Patient factors and surgical factors were included in the analysis(t test for continuous variables, χ² test for categorical variables and independent risk factors from binary Logistic multivariate analysis).

A total of 146 patients(18 patients in the critical complication group, 128 patients in the non-critical complication group)were enrolled.Univariate analysis showed that implanted stent type(P=0.013), number of implanted ¹²⁵I particles(P=0.007), operation time(P=0.000), intraoperative biliary hemorrhage(P=0.000), postoperative biliary hemorrhage(P=0.000), postoperative stent patency time(P=0.000), coexisting biliary stones(P=0.003), preoperative jaundice time(P=0.000), and preoperative biliary obstruction length(P=0.000)were related to critical complications after biliary stent implantation.Operation time of ¹²⁵I seed simple stent group(P=0.011)and the length of preoperative biliary obstruction(P=0.002)were positively correlated with postoperative critical complications.The binary Logistic multivariate analysis concluded that preoperative jaundice time(OR=1.059, P=0.033)and preoperative biliary obstruction length(OR=3.595, P=0.007)were independent risk factors for postoperative critical complications.

There is no significant difference in the incidence of critical complications between percutaneous transhepatic biliary stent implantation and endoscopic biliary stent implantation.Preoperative jaundice time and length of biliary obstruction are independent risk factors for critical complications after biliary stenting.The incidence of critical complications after biliary ¹²⁵I seed stent is higher than that after bare stenting, and there was no significant correlation between the number of implanted ¹²⁵I particles and the incidence of critical complications.

To explore the efficacy and safety of immune checkpoint inhibitor sintilimab combined with regofenib in the treatment of advanced colorectal cancer(CRC).

A total of 90 advanced CRC patients who were treated in Guangzhou First People′s Hospital from January 2020 to January 2022 were prospective selected, and were divided into observation group and control group according to the random number table, with 45 patients in each group.The control group received oral regofini, and the observation group received sintilimab injection on the basis of the control group.The clinical efficacy, tumor markers, immune function, survival time and adverse reaction were compared between the two groups.

After treatment, objective response rate and disease control rate of the observation group were 53.33% and 80.00%, those of the control group were 20.00% and 60.00%(P<0.05). After treatment, carbohydrate antigen 199(CA199), cytokeratin 19 fragment antigen 21-1(CYFRA21-1), carcinoembryonic antigen(CEA)decreased in both groups, and the indicators of the observed group were lower than those of the control group(P<0.05). The proportion of cytotoxic T cells(CD8⁺ )decreased in both groups, while the proportion of helper T cells(CD4⁺ )and CD4⁺ /CD8⁺ ratio increased in both groups.Moreover, the proportion of CD4⁺ and CD4⁺ /CD8⁺ in the observed group were higher than those in the control group(P<0.05), while the proportion of CD8⁺ was lower than that in the control group(P>0.05). The overall survival(P=0.040)and progression-free survival(P=0.046)of the observation group were longer than those of the control group.The incidence of adverse reactions in the observation group was lower than that in the control group(64.44% vs.62.22%, P>0.05).

Immune checkpoint inhibitors sintilimab combined with regofenib has good efficacy and safety in the treatment of the patients with advanced CRC, prolonging survival time and alleviating the pain caused by cancer.

To comprehensively analyze the survival status and prognostic factors of colorectal cancer patients with liver metastasis.

The clinical and follow-up data of 84 patients with liver metastasis from colorectal cancer in the Central Hospital Affiliated to Chongqing University from January to June 2019 were analyzed retrospectively.The basic information of patients was collected, Kaplan-Meier method was used to calculate the median survival time, Log-rank test was used for univariate analysis, and Cox regression model was used to analyze the related factors affecting the prognosis of colorectal cancer patients with liver metastasis.

All 84 patients with liver metastasis from colorectal cancer were followed up, the median follow-up time was 25.5 months, the follow-up rate was 100.0%, and there was no loss of follow-up.The 1-year, 2-year and 3-year survival rates were 84.52%(71/84), 66.67%(56/84)and 51.19%(43/84), respectively.The median survival time was(25.16±5.48)months.The results of univariate analysis showed that whether the body weight decreased more than 20% in recent 6 months was related to the prognosis(P<0.05). There were statistically significant differences between groups in mrEMVI, pathological type, pathological grade, mrT stage, mrN stage, circumferential resection margin(CRM), invasion length, invasion depth, the distance from the lower end of the tumor to the anal margin, and the number of liver metastatic lesions, which were related to the prognosis(P<0.05). There were statistically significant differences in neoadjuvant chemotherapy, operation time and complications between groups, which were related to the prognosis(P<0.05). The influence of each factor on the prognosis of patients from high to low were: weight loss of more than 20% in recent 6 months(OR=2.264), number of liver metastases(OR=2.035), pathological type(OR=1.751), neoadjuvant chemotherapy(OR=1.382), pathological classification(OR=1.186).

Over 20% weight loss, mrEMVI, pathological type, pathological grade, mrT stage, mrN stage, CRM, length of invasion, depth of invasion, distance from the lower end of the tumor to the anal margin, number of liver metastatic lesions, neoadjuvant chemotherapy, operation time and complications are the main factors affecting the prognosis of patients with colorectal cancer with liver transfer.Clinically, timely and effective preventive measures can be taken before and after the operation to benefit the survival of patients and improve the prognosis of patients.

To investigate the effect of Bifidobacterium Triple Viable Powder(Peifeikang)combined with compound Lactobacillus acidophilus tablets in the adjuvant treatment of rotavirus enteritis in children.

A total of 120 children with rotavirus enteritis treated in Guangde People′s Hospital from August 2020 to September 2022 were included and randomly divided into control group, Peifeikang group and combined bacteria group according to random number table method, with 40 cases in each group.The control group was given conventional rehydration treatment, the Peifeikang group was given Peifeikang preparation on the basis of conventional treatment, and the combined bacteria group was given probiotic preparations such as Peifeikang and compound Lactobacillus acidophilus tablets on the basis of conventional treatment.After 1-5 days of treatment, the clinical therapeutic effect, the changes of intestinal probiotics and pathogenic bacteria, intestinal permeability function and serum inflammatory factors were compared among the three groups.

After treatment, the total effective rate of the combined bacteria group was significantly higher than that of the Peifeikang group and the control group(P<0.05). The disappearance time of clinical symptoms(diarrhea, abdominal pain, vomiting and dehydration)in the combined bacteria group was significantly earlier than that in the control group and the Pefikang group.Among the intestinal flora detected, Bifidobacterium intestinalis, Lactobacillus acidophilus and Enterococcus faecalis were increased in the three groups, and the increased proportion in the combined bacteria group was higher than that in the Peifeikang group and the control group(P<0.05). Enteric Escherichia coli and Perfringens were decreased in all three groups, and the reduction degree of the combined bacteria group was higher than that of the Peifeikang group and the control group(P<0.05). The decrease of serum D-lactic acid, DAO, ET and inflammatory factors(TNF-α, IL-1β, IL-6 and IL-17)levels in the combined bacteria group was higher than that in the Peifeikang group and the control group(P<0.05).

On the basis of conventional treatment, combination of Peifeikang and compound Lactobacillus acidophilus tablets can improve the therapeutic effect of rotavirus in children.

To analyze and compare the clinical efficacy and safety of mFOLFOX6 and FOLFOX4 chemotherapy regimens in the treatment of rectal cancer patients.

A total of 118 patients with rectal cancer who were admitted to Xuancheng Central Hospital from January 1, 2020 to August 31, 2022 were selected, and were divided into mFOLFOX6 group(n=59)and FOLFOX4 group(n=59)using random alphabet method.The patients were treated with mFOLFOX6 and FOLFOX4 chemotherapy regimens, respectively.The efficacy and incidence of adverse reactions were compared between the two groups.

There were no significant differences in objective response rate and disease control rate between the mFOLFOX6 group and FOLFOX4 group(P>0.05). The results of flow cytometry showed that there was no significant difference in CD3+ cell subset between the mFOLFOX6 group and FOLFOX4 group after treatment(P>0.05), while CD4+ cell subset and CD4+ /CD8+ ratio in the mFOLFOX6 group were significantly higher than those in the FOLFOX4 group(P<0.05). In terms of quality of life, global health status was improved in both mFOLFOX6 and FOLFOX4 groups after treatment(P<0.05). The scores of functional scale and overall quality of life in the mFOLFOX6 group were significantly higher than those in the FOLFOX4 group, while the score of symptom scale was significantly lower than that in the FOLFOX4 group(P<0.05). The incidences of adverse reactions including nausea and vomiting, diarrhea and peripheral neurotoxicity were similar between the two groups(P>0.05). The incidence ofⅢ-Ⅳleukopenia in the mFOLFOX6 group was slightly higher than that in the FOLFOX4 group, but there was no statistically significant difference(P>0.05). The incidence of liver function damage in the mFOLFOX6 group was significantly higher than that in the FOLFOX4 group, and there was a statistically significant difference(P<0.05).

Both mFOLFOX6 and FOLFOX4 regimen can play a good role in the treatment of rectal cancer, and mFOLFOX6 regimen can improve the quality of life and immune function of patients, but the incidence of liver damage is high, and patients with liver insufficiency should be used carefully.

To explore the therapeutic effect and risk factors of rebleeding in the treatment of liver cirrhosis complicated with esophageal and gastric variceal bleeding with enhanced nutritional support and octreotide.

A total of 112 patients with cirrhosis combined with esophageal and gastric variceal bleeding admitted to Wuxi People′s Hospital from January 2020 to June 2023 were selected.After excluding patients with incomplete data or unwillingness to participate in the study, a total of 90 patients were included.All patients underwent enhanced nutritional support assisted octreotide therapy, and clinical efficacy was observed.The nutritional status of all patients before and after treatment was compared, including triceps skinfold thickness(TSF), arm circumference(AC), and body mass index(BMI). The patients were divided into an observation group(25 cases, rebleeding after treatment)and a control group(65 cases, no bleeding after treatment)based on whether there was rebleeding after treatment.The clinical data of the two groups were Compare, and the independent risk factors of rebleeding in patients with liver cirrhosis combined with esophageal and gastric variceal bleeding after enhanced nutritional support and octreotide treatment were analyzed using univariate and multivariate logistic analysis.

After treatment, all 90 patients did not experience active bleeding, and the success rate of treatment was 100.00%.After treatment, there were 25 cases of rebleeding and 65 cases of no bleeding, with a recurrence rate of 27.78%.The TSF levels of all patients after treatment were lower than before treatment, while the AC and BMI levels were higher than before treatment(P<0.05). The results of univariate logistic analysis showed that age≥65 years, portal vein diameter, Child-Pugh score, blood sodium, and albumin concentration were risk factors for postoperative rebleeding in patients with liver cirrhosis complicated with esophageal and gastric variceal bleeding(P<0.05). The results of multivariate logistic regression analysis showed that age≥65 years, portal vein diameter, Child-Pugh score, blood sodium, and albumin concentration were all independent risk factors for rebleeding in patients with liver cirrhosis complicated with esophageal and gastric variceal bleeding after treatment(OR=6.556, 3.404, 0.598, 1.320, 2.028, P=0.001, 0.000, 0.000, 0.002, 0.000, 95% CI: 3.124-6.335, 1.381-2.358, 3.252-8.612, 1.513-2.192, all P<0.05).

Enhanced nutritional support combined with octreotide is effective in the treatment of esophageal and gastric variceal bleeding in patients with liver cirrhosis.Age≥65 years old, portal vein diameter, Child-Pugh score, blood sodium, and albumin concentration are all risk factors for rebleeding after treatment.Clinicians should pay attention to these factors during treatment and actively control disease progression to reduce the risk of rebleeding after treatment.

To analyze and compare the clinical efficacy and safety of irinotecan chemotherapy regimen and irinotecan combined with ubenimex chemotherapy regimen for the treatment of advanced gastric cancer.

The clinical data of 104 patients with advanced gastric cancer admitted to Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2018 to January 2022 were retrospectively analyzed.According to the different treatment plans adopted by the patients, all the patients were divided into control group(irinotecan chemotherapy plan, n=61)and observation group(irinotecan combined with ubenimex treatment plan, n=43), and were treated with 21 days as 1 cycle for a total of 2 Cycle.The short-term clinical efficacy of the two groups at 1 week after treatment, the levels of CD3+, CD4+, CD4+ /CD8+ in the peripheral blood before and after treatment, the quality of life after treatment, the survival within 1 year after the end of treatment, and the incidence of adverse reactions during treatment were compared.

One week after the end of treatment, the partial response(PR), objective response rate(ORR)and disease control rate(DCR)of patients in the observation group were significantly higher than those of patients in the control group(P<0.05), and the stable disease(SD)and progressive disease(PD)were significantly lower than those of patients in the control group(P<0.05). Before treatment, there were no statistically significant differences in the levels of CD3+, CD4+ and CD4+ /CD8+ in the peripheral blood of the two groups(P>0.05), but after treatment, the levels of CD3+, CD4+ and CD4+ /CD8+ in the peripheral blood of the two groups increased, and the observation group was higher than the control group(P<0.001). After treatment, patients in the observation group had significantly lower scores in the symptom domains of dysphagia and feeding restriction than those in the control group(P<0.05). During the 1-year follow-up, disease progression-free survival was significantly longer in the observation group than in the control group [(7.42±0.89)months vs.(5.35±0.68)months, P<0.001). Comparing the total incidence of adverse reactions during the treatment period between the two groups, there was no statistically significant difference(P>0.05).

The clinical efficacy of irinotecan combined with ubenimex in the treatment of advanced gastric cancer is more significant, which can improve the immunity function of the patients, improve the quality of life of the patients, prolong the progression-free survival time of the patients, with higher safety.