Study on differential diagnosis between acinic cell carcinoma and pleomorphic adenoma with contrast-enhanced ultrasound

doi:10.3877/cma.j.issn.2095-2015.2017.06.003

Abstract

Abstract:

Objective

To investigate the value of differential diagnosis between acinic cell carcinoma and pleomorphic adenoma with contrast-enhanced ultrasound(CEUS).

Methods

A total of 20 acinic cell carcinomas and 98 pleomorphic adenomas with presurgical routine two-dimensioned ultrasound and CEUS were retrospectively analyzed in Sichuan Provincial People′s Hospital from April 2008 to May 2016, which were confirmed by surgical pathology.Qontrast 4.0 imaging analysis software was applied to gain peak intensity(PI), time to peak(TTP), regional blood flow(RBF), the max signal intensity(SImax), the mean signal intensity(SImean)through quantitative analysis.

Results

The manifestations of conventional two-dimensional ultrasound examination between salivary gland acinic cell carcinoma and pleomorphic adenoma in morphology, internal echo, the boundary showed no statistically significant difference(P>0.05). While CEUS results showed that acinic cell carcinoma was remarkably higher than pleomorphic adenoma in PI(54.28±10.34 vs.44.20±16.41), RBF(68.22±17.86 vs.50.84±26.12), SImax(65.74±9.41 vs.56.54±14.45)and SImean(54.21±10.15 vs.44.26±16.44), and the differences were statistically significant(P<0.05).

Conclusion

CEUS quantitative analysis parameters are helpful to differentially diagnose salivary gland acinar cell carcinoma and pleomorphic adenoma.

Key words: Contrast-enhanced ultrasound, Salivary gland acinic cell carcinoma, Salivary gland pleomorphic adenoma, Differential analysis

Jiamei Gou, Qin Chen. Study on differential diagnosis between acinic cell carcinoma and pleomorphic adenoma with contrast-enhanced ultrasound[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(06): 247-251.

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Figures/Tables 6

References 11

1	汤国雄，朱声荣，陈卫民，等．腮腺多形性腺瘤及其恶变中β～连环蛋白、细胞周期蛋白D1的表达[J]．临床口腔医学杂志，2009，25(3)：131-133.
2	陈琴，岳林先．浅表器官超声造影诊断图谱[M]．北京：人民卫生出版社，2015：163，239.
3	Laskawi R, Rodel R, Zirk A, et al.Retrospective analysis of 35 patients with acinic cell carcinoma of the parotid gland[J]. J Oral Maxillofac Surg, 1998, 56(8): 440-443.
4	Vander Poorten V, Triantafyllou A, Thompson LD, et al.Salivary acinic cell carcinoma: reappraisal and update[J]. Eur Arch Otorhinolaryngol, 2016, 273(11): 3511-3531.
5	Li J, Gong X, Xiong P, et al.Ultrasound and computed tomography features of primary acinic cellcarcinoma in the parotid gland: A retrospective study[J]. EurJ Radiol, 2014, 83(7): 1152-1156.
6	Wu S, Liu G, Chen R, Guan Y. Role of ultrasound in the assessment of benignity and malignancy of parotid masses[J]. Dentomaxillofac Radiol, 2012, 41(2): 131-135.
7	Bialek EJ, Jakubowski W, Zajkowski P, et al.US of the majorsalivary glands: anatomy and spatial relationships, pathologic conditions, and pitfalls[J]. Radiographics, 2006, 26(3): 745-763.
8	Zajkowski P, Jakubowski W, Bialek EJ, et al.Pleomorphic adenoma and adenolymphoma in ultrasonography[J]. Eur J Ultrasound, 2000, 12(1): 23-29.
9	贾传海，瞿俊晨，丁庆国，等．涎腺腺泡细胞癌的影像学特征[J]．医学影像学杂志，2016，26(2)：218-221.
10	Fisher DE, Baltzer P, Malich A, et al.Is the " blooming sign" a promising additional tool to determine malignancy in MRmammography? [J]. Eur Radiol, 2004, 14(3): 394-401.
11	熊雅玲，郝晶，王辉，等．实时灰阶超声造影增强模式在甲状腺结节鉴别诊断中的应用[J]．中国超声医学杂志，2011，27(11)：980-983.

组别	例数	形态		边界		内部回声
组别	例数	规则	不规则	清楚	不清楚	均匀	不均匀
涎腺腺泡细胞癌	20	13	7	16	4	11	9
涎腺多形性腺瘤	98	74	24	85	13	68	30
χ²值	?	0.947		0.611		1.554
P值	?	0.330		0.434		0.213

组别	例数	形态		边界		内部回声
组别	例数	规则	不规则	清楚	不清楚	均匀	不均匀
涎腺腺泡细胞癌	20	13	7	16	4	11	9
涎腺多形性腺瘤	98	74	24	85	13	68	30
χ²值	?	0.947		0.611		1.554
P值	?	0.330		0.434		0.213

定量参数	PEAK(%)	TTP(s)	RBF(%)	Slmax(%)	Slmean(%)
涎腺腺泡细胞癌	54.28±10.34	27.19±7.94	68.22±17.86	65.74±9.41	54.21±10.15
涎腺多形性腺瘤	44.20±16.41	41.16±22.19	50.84±26.12	56.54±14.45	44.26±16.44
t值	－2.58	2.7	－2.767	－2.656	－2.536
P值	0.01	0.008	0.007	0.009	0.013

定量参数	PEAK(%)	TTP(s)	RBF(%)	Slmax(%)	Slmean(%)
涎腺腺泡细胞癌	54.28±10.34	27.19±7.94	68.22±17.86	65.74±9.41	54.21±10.15
涎腺多形性腺瘤	44.20±16.41	41.16±22.19	50.84±26.12	56.54±14.45	44.26±16.44
t值	－2.58	2.7	－2.767	－2.656	－2.536
P值	0.01	0.008	0.007	0.009	0.013

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