The strategies for treating cancers have achieved significant progress in the past decade, while the mortality rate of hepatobiliary malignancies remains high.Hepatobiliary malignancies are featured as the diseases with abundant heterogeneity that are varied in clinic backgrounds, pathological phenotypes and biological characteristics, which need more precise in classification and clinical therapy.Precision medicine for hepatobiliary malignancies, based on personalized diagnosis and treatment requires more clinical practices.Meanwhile, the precision immunotherapy is the major direction for the development of clinical application, so that it is crucial for clinicians to construct a multidisciplinary team using cutting-edge diagnostic and therapeutic techniques and guided by clinical problems to explore the precision oncology and immunotherapy models of in patients with hepatobiliary malignancies.