With the continuous improvement of living conditions and the change of diet structure, the incidence of non-alcoholic fatty liver disease(NAFLD)is increasing, which has become a global problem and has attracted wide attention in our country.NAFLD has the characteristics of concealment of early onset.At present, conventional clinical diagnosis requires imaging examination, laboratory examination and other non-invasive methods, as well as pathological invasive examination if necessary, of which pathology is the gold standard for the diagnosis of NAFLD, also the progression of the disease.The primary goal of NAFLD treatments is to lose weight and improve insulin resistance.Also to prevent and treat MetS, type 2 diabetes mellitus(T2DM), metabolic syndrome(METS)and related complications are important.These are aimed to reduce the burden of disease, to improve the quality of life and prolong life.The secondary goal is to reduce liver fat deposition.Lifestyle change is currently recommended as the most effective way to treat NAFLD.Weight loss in obese patients is a necessary treatment.But severe NAFLD patients have to undergo liver transplantation.