Correlation between pancreatic fat deposit quantified by 3.0T magnetic resonance chemical shift technology and type 2 diabetes mellitus

doi:10.3877/cma.j.issn.2095-2015.2020.02.007

Abstract

Abstract:

Objective

To investigate the quantitative difference of pancreatic fat fraction(PFF)in patients with type 2 diabetes mellitus(T2DM)and normal blood glucose(NBG)by magnetic resonance chemical shift technique, and the correlation between pancreatic fat deposition and T2DM.

Methods

The clinical data and biochemical indexes of fat metabolism of 66 patients with T2DM and 84 patients with NBG who underwent 3.0T MRI examination of the upper abdomen were analyzed retrospectively.The percentages of pancreatic fat content(PFC)in T2DM group and NBG group were measured on both in-phase and opposed-phase sequence images.The difference of PFC was analyzed between T2DM group and NBG group, as well as the correlation with age, gender, body mass index(BMI)and biochemical indexes of fat metabolism.

Results

The average PFF, and focal PFF of pancreatic head, body and tail were 3.7%-10.56%, 2.34%-11.08%, 2.25%-11.33% and 2.34%-13.46% in T2DM group, and 2.4%-7.46%, 1.38%-7.88%, 0.77%-8.59% and 1.38%-9.58% in NBG group.The average PFF(t=4.371, P=0.000), focal PFF of pancreatic head(t=3.231, P=0.002), focal PFF of pancreatic body(t=3.052, P=0.003), focal PFF of pancreatic tail(t=2.962, P=0.004)in T2DM group were significantly higher than those in NBG group.The triglycerides(t=2.614, P=0.010)and very low-density lipoprotein cholesterol(t=2.271, P=0.025)in T2DM group were higher than those in NBG group.The high density lipoprotein cholesterol(t=-2.560, P=0.011)in T2DM group was lower than that in NBG group.PFC of T2DM group was positively correlated with age(r=0.366, P=0.003)and BMI(r=0.303, P=0.013).

Conclusion

The PFF in T2DM group is significantly higher than that in NBG group, which indicates that the fat deposition of pancreas is closely related to T2DM and may be a potential risk factor for T2DM.

Key words: Type 2 diabetes, Pancreas, Fat deposition, Magnetic resonance imaging, Chemical shift imaging

Xiuping Duan, Yan Lei, Wei Tang, Xinghui Li, Zhaohua Zhai, Xiaoming Zhang. Correlation between pancreatic fat deposit quantified by 3.0T magnetic resonance chemical shift technology and type 2 diabetes mellitus[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(02): 74-79.

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Figures/Tables 6

References 24

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指标	2型糖尿病组(n＝66)	血糖正常组(n＝84)	P值
男/女(例)	31/35	41/43	0.823
年龄(岁)	63.17±11.07	60.65±11.28	0.174
BMI(kg/m²)	23.62±3.30	22.19±3.31	0.009
TG( mmol/L )	1.94±1.28	1.45±0.92	0.010
TC(mmol/L)	4.58±1.26	4.62±1.09	0.853
HDL-C(mmol/L)	1.08±0.38	1.24±0.37	0.011
LDL-C(mmol/L)	2.43±0.86	2.54±0.72	0.403
VLDL-C(mmol/L)	1.05±0.71	0.84±0.44	0.025
Apo A1(g/L)	1.09±0.27	1.33±1.32	0.142
Apo B100(g/L)	0.83±0.27	5.19±30.82	0.198
Lp(a)(mg/L)	138.77±159.23	197.6±258.75	0.089
胰腺平均脂肪分数(%)	7.13±3.43	4.93±2.53	0.000
胰头脂肪分数(%)	6.71±4.37	4.63±3.25	0.002
胰体脂肪分数(%)	6.79±4.54	4.68±3.91	0.003
胰尾脂肪分数(%)	7.90±5.56	5.48±4.10	0.004

指标	2型糖尿病组(n＝66)	血糖正常组(n＝84)	P值
男/女(例)	31/35	41/43	0.823
年龄(岁)	63.17±11.07	60.65±11.28	0.174
BMI(kg/m²)	23.62±3.30	22.19±3.31	0.009
TG( mmol/L )	1.94±1.28	1.45±0.92	0.010
TC(mmol/L)	4.58±1.26	4.62±1.09	0.853
HDL-C(mmol/L)	1.08±0.38	1.24±0.37	0.011
LDL-C(mmol/L)	2.43±0.86	2.54±0.72	0.403
VLDL-C(mmol/L)	1.05±0.71	0.84±0.44	0.025
Apo A1(g/L)	1.09±0.27	1.33±1.32	0.142
Apo B100(g/L)	0.83±0.27	5.19±30.82	0.198
Lp(a)(mg/L)	138.77±159.23	197.6±258.75	0.089
胰腺平均脂肪分数(%)	7.13±3.43	4.93±2.53	0.000
胰头脂肪分数(%)	6.71±4.37	4.63±3.25	0.002
胰体脂肪分数(%)	6.79±4.54	4.68±3.91	0.003
胰尾脂肪分数(%)	7.90±5.56	5.48±4.10	0.004

变量名称	2型糖尿病组(n＝66)		血糖正常组(n＝84)
变量名称	r值	P值	r值	P值
年龄	0.366	0.003	0.276	0.011
BMI	0.303	0.013	0.350	0.001
TG	－	0.973	－	0.373
TC	－	0.435	－	0.985
LDL-C	－	0.068	－	0.648
HDL-C	－	0.894	－	0.17
VLDL-C	－	0.437	－	0.051
Apo A1	－	0.341	－	0.313
Apo B100	－	0.481	－	0.867
Lp(a)	－	0.529	－	0.919

变量名称	2型糖尿病组(n＝66)		血糖正常组(n＝84)
变量名称	r值	P值	r值	P值
年龄	0.366	0.003	0.276	0.011
BMI	0.303	0.013	0.350	0.001
TG	－	0.973	－	0.373
TC	－	0.435	－	0.985
LDL-C	－	0.068	－	0.648
HDL-C	－	0.894	－	0.17
VLDL-C	－	0.437	－	0.051
Apo A1	－	0.341	－	0.313
Apo B100	－	0.481	－	0.867
Lp(a)	－	0.529	－	0.919

年龄(岁)	胰腺平均脂肪分数		P值	胰头脂肪分数		P值
年龄(岁)	2型糖尿病组	血糖正常组	P值	2型糖尿病组	血糖正常组	P值
30～39	5.44	3.57±0.66	0.261	3.91	3.59±0.85	0.815
40～49	4.70±1.74	4.13±1.68	0.520	6.19±3.81	3.99±3.24	0.227
50～59	6.07±2.58	4.04±1.78	0.007	5.81±3.64	4.24±2.51	0.125
60～69	7.48±3.60	5.64±2.86	0.034	6.48±4.12	5.05±3.8	0.176
70～79	8.23±3.79	4.79±1.94	0.010	7.49±5.97	4.63±2.28	0.131
≥80	9.2±4.12	6.8±4.33	0.395	9.9±3.67	5.36±5.08	0.144
年龄(岁)	胰体平均脂肪分数		P值	胰尾平均脂肪分数		P值
年龄(岁)	2型糖尿病组	血糖正常组	P值	2型糖尿病组	血糖正常组	P值
30～39	3.61	2.73±0.48	0.379	8.81	4.38±3.33	0.473
40～49	2.33±0.27	3.99±2.73	0.072	5.58±2.17	4.4±2.20	0.309
50～59	5.51±3.15	3.73±2.54	0.062	6.88±3.99	4.13±3.42	0.028
60～69	7.24±4.63	4.9±4.3	0.052	8.73±6.23	6.97±4.86	0.230
70～79	8.64±4.51	5.67±4.45	0.119	8.55±7.03	4.06±2.16	0.046
≥80	9.8±6.74	7.55±6.8	0.613	7.9±6.16	7.49±5.39	0.914

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