To explore the role of α₁ adrenergic receptor(α₁AR)blocker in reducing portal hypertension in liver cirrhosis.

Fifty mice were divided into 5 groups by random number table method.Carbon tetrachloride(CCl₄)was used to model liver cirrhosis, and doxazosin was used as α₁AR blocker.The mice were grouped into: ①olive oil group, ②CCl₄ group, ③CCl₄₊ doxazosin 2.5 mg/(kg*day)group, ④CCl₄₊ doxazosin 5 mg/(kg*day)group, ⑤CCl₄₊ doxazosin 10 mg/(kg*day)group.At the end of the intervention, portal venous pressure was measured and statistically analyzed.

α₁AR blocker(doxazosin)could reduce the mortality of mice with liver cirrhosis.Compared with the olive oil group, the portal venous pressures of the mice in the other four groups were significantly higher(all P<0.05). Compared with the CCl₄ group, the portal venous pressure levels of mice in the CCl₄₊ doxazosin 2.5 mg/(kg*day)group and CCl₄₊ doxazosin 5 mg/(kg*day)group were statistically reduced, but there were no statistically significant differences(both P>0.05). Compared with the CCl₄ group, the portal pressure level of mice in the CCl₄₊ doxazosin 10 mg/(kg*day)group was significantly reduced, and there was a statistically significant difference(P<0.05).

α₁AR blocker(doxazosin)can inhibit the increase of portal venous pressure in cirrhotic mice and reduce the mortality of cirrhotic mice, which may provide new ideas for the treatment of portal hypertension in cirrhosis.