Research progress on the mechanism, diagnosis and prognosis of long non-coding RNA in gastric cancer

doi:10.3877/cma.j.issn.2095-2015.2021.06.010

Abstract

Abstract:

Gastric cancer is one of the most common causes of cancer death in the world. However, due to the lack of obvious clinical symptoms in the early stage of gastric cancer, most patients with gastric cancer were diagnosed in advanced stage. Therefore, the study of gastric cancer should not only understand the mechanism of occurrence and development, but also search for new early diagnosis methods and establish effective prognostic evaluation methods. Long non-coding RNA (lncRNA) is an important epigenetic regulator and plays an important role in human tumors. However, the mechanism of differentially expressed lncRNA in gastric cancer has not been fully elucidated. With the development of modern medicine, more and more studies have revealed the mechanism of abnormal expression of lncRNA in the occurrence, development, diagnosis and prognosis of gastric cancer.

Key words: Long non-coding RNA, Gastric cancer, Diagnosis, Prognosis, Molecular markers

Zhiqiang Xiang, Ping Guo, Changqing Yang, Zibai Wei. Research progress on the mechanism, diagnosis and prognosis of long non-coding RNA in gastric cancer[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2021, 11(06): 291-295.

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LncRNA	相对表达	分子机制	细胞生物学	临床病理征	引用文献
HOTAIR	上调	HOTAIR通过海绵化miR-1277和上调COL5A1	增殖、转移	预后不良	12
GALNT5 uaRNA	上调	GALNT5 uaRNA与HSP90相互作用并降低AKT和IKK的泛素化	增殖、迁移	TNM分期、淋巴结转	13
MAGI2-AS3	上调	MAGI2-AS3受BRD4调控，通过miR-141/200A维持ZEB1过表达	迁移、侵袭	预后不良、TNM分期	14
HCG11	上调	HCG11通过靶向miR-1276/CTNNB1和激活Wnt	增殖和迁移	-	15
LUCAT1	上调	LUCAT1通过调节miR-134-5p/YWHAZ	增殖、侵袭、迁移	预后不良、淋巴结转移、临床分期	16
MALAT1	上调	MARA T1通过PI3K/AKT途径	侵袭、迁移、细胞周期	临床分期、预后	17
LINC00673	上调	LINC00673通过作为LSD1和EZH2的支架并抑制KLF2和LATS2	迁移、侵袭和转移	预后不良、肿瘤大小、淋巴结转移	18
PVT1	上调	PVT1与FOXM1相互作用并上调其表达	增殖、侵袭、转移	肿瘤大小、肿瘤深度、预后不良、远处转移	19
MGE3	上调	MEG3通过p53信号通路抑制胃癌增殖和转移	增殖和转移	肿瘤大小、预后不良	20
PCAT18	下调	PCAT18通过抑制miR-135B促进CLDN11表达	增殖、迁移和侵袭	与miR-135B负相关	21
LINC01133	下调	LINC01133通过海绵化miR-106a-3p调节APC表达和Wnt/β-catenin途径抑制胃癌进展	生长、侵袭、转移	肿瘤进展和不良预后、TNM分期、远处转移和瘤周组织浸润	22
PTCSC3 Linc-pint	下调	PTCSC3和Linc-pint通过形成正反馈调控环抑制癌细胞	增殖、癌细胞的干性	预后不良	23
HAND2-AS1	下调	HAND2-AS1通过miR-184/HIF3A通路	细胞增殖、迁移、侵袭能力和糖酵解过程	-	24
SNHG5	下调	通过miR-32调节KLF4表达	扩散和迁移	与miR-32程负相关	25
FER1L4	下调	FER1L4通过抑制Hippo-Yap信号通路	细胞增殖和侵袭	淋巴结转移、远处移、预后不良	26
GAS5	下调	Gas5过表达通过靶向p53抑制胃癌细胞	侵袭、迁移	-	27

LncRNA	相对表达	分子机制	细胞生物学	临床病理征	引用文献
HOTAIR	上调	HOTAIR通过海绵化miR-1277和上调COL5A1	增殖、转移	预后不良	12
GALNT5 uaRNA	上调	GALNT5 uaRNA与HSP90相互作用并降低AKT和IKK的泛素化	增殖、迁移	TNM分期、淋巴结转	13
MAGI2-AS3	上调	MAGI2-AS3受BRD4调控，通过miR-141/200A维持ZEB1过表达	迁移、侵袭	预后不良、TNM分期	14
HCG11	上调	HCG11通过靶向miR-1276/CTNNB1和激活Wnt	增殖和迁移	-	15
LUCAT1	上调	LUCAT1通过调节miR-134-5p/YWHAZ	增殖、侵袭、迁移	预后不良、淋巴结转移、临床分期	16
MALAT1	上调	MARA T1通过PI3K/AKT途径	侵袭、迁移、细胞周期	临床分期、预后	17
LINC00673	上调	LINC00673通过作为LSD1和EZH2的支架并抑制KLF2和LATS2	迁移、侵袭和转移	预后不良、肿瘤大小、淋巴结转移	18
PVT1	上调	PVT1与FOXM1相互作用并上调其表达	增殖、侵袭、转移	肿瘤大小、肿瘤深度、预后不良、远处转移	19
MGE3	上调	MEG3通过p53信号通路抑制胃癌增殖和转移	增殖和转移	肿瘤大小、预后不良	20
PCAT18	下调	PCAT18通过抑制miR-135B促进CLDN11表达	增殖、迁移和侵袭	与miR-135B负相关	21
LINC01133	下调	LINC01133通过海绵化miR-106a-3p调节APC表达和Wnt/β-catenin途径抑制胃癌进展	生长、侵袭、转移	肿瘤进展和不良预后、TNM分期、远处转移和瘤周组织浸润	22
PTCSC3 Linc-pint	下调	PTCSC3和Linc-pint通过形成正反馈调控环抑制癌细胞	增殖、癌细胞的干性	预后不良	23
HAND2-AS1	下调	HAND2-AS1通过miR-184/HIF3A通路	细胞增殖、迁移、侵袭能力和糖酵解过程	-	24
SNHG5	下调	通过miR-32调节KLF4表达	扩散和迁移	与miR-32程负相关	25
FER1L4	下调	FER1L4通过抑制Hippo-Yap信号通路	细胞增殖和侵袭	淋巴结转移、远处移、预后不良	26
GAS5	下调	Gas5过表达通过靶向p53抑制胃癌细胞	侵袭、迁移	-	27

LncRNA	生物标志类型	表达	研究对象	AUC	样本	引用文献
HOTTIP	诊断	高	126例胃癌患者和120名健康对照者	0.827	血清	30
SpRY4-IT1	诊断	高	68例胃癌患者和50名健康对照者	-	血清	31
GASL1	诊断	低	88例胃癌患者和72名健康对照者	0.8945	血清	32
H19	诊断	高	35例胃癌患者和25名健康对照者	0.982	血浆	37
H19	诊断	高	70例胃癌患者和70名健康对照者	0.838	血浆	36
UCA1	诊断	高	26例胃癌患者和23名健康对照者	0.721	胃液	34
ZNFX1-AS1	诊断	高	50例胃癌患者和50名健康对照者	0.85	血浆	35
ABHD11-AS1	诊断	高	170例胃癌患者和130例胃癌患者	0.653	胃液	33
UCA1	预后	高	20例胃癌患者和20名健康对照者	0.928	胃癌组织	38
IGF2-AS	预后	高	375例胃癌患者和32名健康对照者	-	胃癌组织	39
VPS9D1-AS1	预后	低	126例胃癌患者	-	胃癌组织	40
PTCSC3	预后	低	68例胃癌患者和60名健康对照者	0.92	血浆	41
Epel	预后	高	64例胃癌患者	-	胃癌组织	42
ZFAS1	预后	高	77例胃癌患者和60名健康对照者	0.727	血浆	43

LncRNA	生物标志类型	表达	研究对象	AUC	样本	引用文献
HOTTIP	诊断	高	126例胃癌患者和120名健康对照者	0.827	血清	30
SpRY4-IT1	诊断	高	68例胃癌患者和50名健康对照者	-	血清	31
GASL1	诊断	低	88例胃癌患者和72名健康对照者	0.8945	血清	32
H19	诊断	高	35例胃癌患者和25名健康对照者	0.982	血浆	37
H19	诊断	高	70例胃癌患者和70名健康对照者	0.838	血浆	36
UCA1	诊断	高	26例胃癌患者和23名健康对照者	0.721	胃液	34
ZNFX1-AS1	诊断	高	50例胃癌患者和50名健康对照者	0.85	血浆	35
ABHD11-AS1	诊断	高	170例胃癌患者和130例胃癌患者	0.653	胃液	33
UCA1	预后	高	20例胃癌患者和20名健康对照者	0.928	胃癌组织	38
IGF2-AS	预后	高	375例胃癌患者和32名健康对照者	-	胃癌组织	39
VPS9D1-AS1	预后	低	126例胃癌患者	-	胃癌组织	40
PTCSC3	预后	低	68例胃癌患者和60名健康对照者	0.92	血浆	41
Epel	预后	高	64例胃癌患者	-	胃癌组织	42
ZFAS1	预后	高	77例胃癌患者和60名健康对照者	0.727	血浆	43

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