Abstract:
Objective To explore the correlation between changes in the volume of gray matter and cognitive impairment in patients with subcortical ischemic vascular disease(SIVD)with cognitive impairment based on the voxel morphology measurement(VBM)method in structural magnetic resonance imaging(sMRI)to fully automatic segmentation of brain tissue.
Methods From September 2020 to September 2022, 80 patients from the Department of Neurology of Hongqi Hospital Affiliated to Mudanjiang Medical College were collected, and the subjects were divided into dementia group(SIVD-AD, n=23), mild cognitive impairment group(SIVD-MCI, n=33)and non-cognitive impairment group(SIVD-NCI, n=24)according to the neuropsychological assessment of the degree of cognitive decline.The 3D-T1TFE sagittal structure image was collected by 3.0T MRI, and the brain tissue was automatically segmented by VBM-CAT12 toolbox in SPM12 software package of MATLAB platform, and the regions of interest were delineated in the DPABI software.All images were calibrated for atrophy using the AAL template in the Viewer package.
Results Compared with the SIVD-NCI group, the SIVD-MCI group mainly showed gray matter atrophy changes in the right frontal upper gyrus, midfrontal gyrus and temporal middle gyrus.The SIVD-AD group mainly showed atrophic changes in the bilateral fusiform gyrus, bilateral cingulate gyrus, bilateral olfactory cortex, left supra frontal gyrus, left midfrontal gyrus, left parahippocampal gyrus, left straight gyrus, left insular lobe and right caudate nucleus.
Conclusion sMRI has the characteristics of non-invasive and radiation-free, which can be used as an effective screening choice for MCI and AD in the general population, and has important value in improving clinical practice.
Key words:
Cognitive impairment,
Structural magnetic resonance imaging,
Voxel morphology measurement,
Gray matter atrophy
Jinyi Zhao, Zhengying Sun, Hongyi Li, Mingcheng Hu, Xiaoshen Wang, Xiaohang Shi, Yuning Wang, Weiyang Sun, Jian Xing. Imaging study of assessment of gray matter atrophy in patients with subcortical ischemic cerebrovascular disease with cognitive impairment based on structural magnetic resonance imaging[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(01): 10-14.