Abstract:
Objective To evaluate the clinical efficacy and adverse effects of oxycodone, hydromorphone and sufentanil on postoperative analgesia in gastric cancer patients.
Methods The gastric cancer patients who underwent radical surgery for gastric cancer in anesthesia analgesia system of the Fifth Affiliated Hospital of Sun Yat-sen University from June 1, 2020 to June 31, 2022 were retrieved.According to the postoperative analgesic plan, the patients were divided into hydromorphone group(n=108), oxycodone group(n=35)and sufentanil group(n=42). General baseline data such as age, gender, BMI, ASA classification, surgical approach, lymph node dissection, and postoperative complications were collected from all patients.Visual analogue scale(VAS)of rest and activity at 4-8 hours(T1), 10-14 hours(T2), 22-26 hours(T3), and 46-50 hours(T4), the number of presses of self-controlled analgesic pump and the incidence of postoperative adverse reactions were compared among the three groups.
Results There was no statistically significant difference in general information among the three groups of patients(P>0.05). In the postoperative T1, T2, T3 and T4 moments, the analgesic effects of the oxycodone group and the hydromorphone group were better than those of the sufentanil group, with statistically significant differences(P<0.05); the analgesic effect of the oxycodone group and the hydromorphone group was the same(P>0.05). The total number of self-control presses of the analgesic pump in the oxycodone group and the hydromorphone group was less than that of the sufentanil group in 48 h(P<0.05); the total number of self-control presses of the analgesic pump in the oxycodone group was not significantly different from that of the hydromorphone group(P>0.05). In addition, there was no significant difference in the total incidence of adverse reactions among the three analgesic regimens(P>0.05).
Conclusion Oxycodone and hydromorphone analgesic regimen have better analgesic effects than sufentanil regimen, which can significantly reduce postoperative pain in gastric cancer patients, and have higher safety.
Key words:
Gastric cancer,
Oxycodone,
Hydromorphone,
Radical surgery for gastric cancer,
Analgesia,
Adverse effects
Hongyu Xu, Yashuang He. Efficacy of oxycodone and hydromorphone in postoperative analgesia after radical gastrectomy for gastric cancer[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(05): 312-316.