Abstract:
Objective To explore the risk factors of stenosis after endoscopic submucosal dissection(ESD)for early esophageal cancer and intraepithelial neoplasia, and to provide basis for clinical prevention and treatment of stenosis.
Methods From January 2015 to December 2020, 155 patients with early esophageal cancer and intraepithelial neoplasia treated with ESD in the 960th Hospital of the PLA Joint Logistics Support Force were retrospectively analyzed.The general data, lesion characteristics, operation and the occurrence of esophageal stricture were collected, and the risk factors of stricture after ESD were analyzed by univariate and multivariate Logistic regression.
Results Of 155 patients, esophageal stricture occurred in 23 patients(14.8%). Multivariate analysis showed that esophageal stricture after ESD was significantly correlated with circumferential lesion area>3/4, tumor invasion depth m3-sm1, lesion longitudinal diameter≥50 mm and esophageal endoscopic mucosal resection(EMR)/ESD history.
Conclusion The independent risk factors of esophageal stricture after ESD are circumferential lesion area>3/4, depth of tumor invasion m3-sm1, longitudinal diameter of lesion≥50 mm and history of esophageal EMR/ESD.
Key words:
Esophageal cancer,
Intraepithelial neoplasia,
Endoscopic submucosal dissection,
Esophageal stricture,
Risk factors
Chao Hou, Meichen Pan, Wenming Wu, Xingguang Huang, Xiang Li, Lingxue Cheng, Yuxuan Zhu, Wenbo Li. Risk factors of esophageal stricture after endoscopic submucosal dissection for early esophageal carcinoma and intraepithelial neoplasia[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 383-387.