Application of endoscopic ultrasonography-guided fine needle aspiration in pancreatic space-occupying lesions

doi:10.3877/cma.j.issn.2095-2015.2023.06.011

Abstract

Abstract:

Objective

To explore the application value of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA)in pancreatic space-occupying lesions.

Methods

A retrospective analysis was performed on 82 patients with pancreatic space-occupying lesions diagnosed by imaging examination(abdominal B-ultrasound, CT, MRI)and underwent EUS-FNA in Northern Jiangsu People′s Hospital from September 2, 2017 to October 2, 2020.The sensitivity, accuracy and specificity of EUS-FNA for pancreatic space-occupying lesions were statistically analyzed.

Results

In 82 patients with pancreatic space puncture, the diagnostic accuracy of EUS-FNA was 90.2%, the specificity was 100%, and the sensitivity was 88.2%.The diagnostic accuracy of lesions>2 cm was significantly higher than that of lesions≤2 cm, with a statistically significant difference(P<0.05).

Conclusion

The EUS-FNA in the diagnosis of pancreatic space-occupying lesions has high sensitivity and specificity, and it has important value for the early diagnosis of pancreatic cancer.The diagnostic accuracy and sensitivity of EUS-FNA are positively correlated with the size of the pancreatic masses.

Key words: Pancreatic space-occupying lesions, Endoscopic ultrasonography-guided fine needle aspiration, Diagnosis

Xinxin Sun, Jun Liu, Chaowu Chen, Chao Sun. Application of endoscopic ultrasonography-guided fine needle aspiration in pancreatic space-occupying lesions[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 418-421.

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https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2023/V13/I06/418

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References 20

1	Mizrahi JD，Surana R，Valle JW，et al.Pancreatic cancer [J]．Lancet，2020，395：2008-2020.
2	Xia C，Dong X，Li H，et al.Cancer statistics in China and United States，2022：profiles，trends，and determinants[J]．Chin Med J(Engl)，2022，135(5)：584-590.
3	Sun D，Cao M，Li H，et al.Cancer burden and trends in China：a review and comparison with Japan and South Korea[J]．Chin J Cancer Res，2020，32(2)：129-139.
4	Wang ZH，Liu T．MicroRNA21 Meets Neuronal TLR8：Non-canonical Functions of MicroRNA in Neuropathic Pain[J]．Neurosci Bull，2019，35：949-952.
5	Tyng CJ，Almeida MFA，Barbosa PNV，et al.Computed tompgraphy-guided percutaneous core needle biopsy in pancreastic tumor diagnosis[J]．WJG，2015，21(12)：3579-3586.
6	Thomas H．IL-6 drives niche formation in pancreatic cancer liver metast[J]．Nat Rev Gastroenterol Hepatol，2019，16(5)：263.
7	Ferlay J，Soerjomataram I，Dikshit R，et al.Cancer incidence and mortality worldwide：sources，methods and major patterns in GLOBOCAN 2012[J]．Int J Cancer，2015，136(5)：E359-384.
8	Siegel RL，Miller KD，Fuchs HE，et al.Cancer Statistics，2022 [J]．CA Cancer J Clin，2022，72(1)：7-33.
9	Noguchi K，Nakai Y，Mizuno S，et al.Role of endoscopic ultrasonography-guided fine needle aspiration/biopsy in the diagnosis of autoimmune pancreatitis[J]．Diagnostics(Basel)，2020，10(11)：954.
10	Sweeney J，Soong L，Goyal A．Endoscopic Ultrasound-Guided Tissue Acquisition of Solid Mass Lesions of the Pancreas：A Retrospective Comparison Study of Fine-Needle Aspiration and Fine-Needle Biopsy[J]．Diagn Cytopathol，2020，48(4)：322-329.
11	Singhi AD，Koay EJ，Chari ST，et al.Early detection of pancreatic cancer：opportunities and challenges[J]．Gastroenterology，2019，156(7)：2024-2040.
12	Wood LD，Canto MI，Jaffee EM，et al.Pancreatic Cancer：Pathogenesis，Sc reening，Diagnosis，and Treatment [J]．Gastroenterology，2022，163(2)：386-402.
13	Zhao YJ，Zhuang LP，Liu YY，et al.Comparative study of laparoscopic versus open radical open radical gastrectomy in advanced gastric neuroendocirne carcinoma：Analysis from a high-volume institution[J]．Asian J Surg，2020，43(3)：488-496.
14	Kleeff J，Korc M，Apte M，et al.Pancreatic cancer[J]．Nat Rev Dis Primers，2016，2：16022.
15	Smith RA，Andrews KS，Brooks D，et al.Cancer screening in the United States，2019：A review of current American Cancer Society guidelines and current issues in cancer screening[J]．CA Cancer J Clin，2019，69(3)：184-210.
16	Alkhateeb K，Lee B，Alatassi H，et al.Comparison between Two Types of Needles for Endoscopic Ultrasound(EUS)-Guided Fine Aspiration Biopsy of Pancreatic and Upper Gastrointestinal Masses [J]．Diagn Cytopathol，2020，48(3)：197-202.
17	Angelis D C，Brizzi RF，Pellicano R．Endoscopic ultrasonography for pancreatic cancer：current and future perspectives[J]．J Gastrointest Oncol，2013，4(2)：220-230.
18	Meng HL，Li SW，Song YL，et al.Effect of different histopathological grading standards on the diagnosis of pancreatic cancer by endoscopic ultrasonography guided fine needle aspiration[J]．J Clin Hepatol，2021，37(2)：390-395.
19	Saqib M，Maruf M，Bashir S，et al.EUS-FNA，ancillary studies and their clinical utility in patients with mediastinal，pancreatic，and other abdominal lesions [J]．Diagn Cytopathol，2020，48(11)：1058-1066.
20	Chen G，Liu S，Zhao Y，et al.Diagnostic accuracy of endoscopic ultrasound—guided fine-needle aspiration for pancreatic cancer：a mata—annalysis[J]．Pancreatology，2013，13：298-304.

EUS-FNA	性别		超声表现		病灶直径		病变部位
EUS-FNA	男(n＝59)	女(n＝23)	囊实混合性(n＝14)	实性(n＝68)	>2 cm(n＝74)	≤2 cm(n＝8)	胰头颈部(n＝58)	胰体尾部(n＝24)
阳性	44	16	10	50	58	2	43	17
阴性	15	7	4	18	16	6	15	7
χ²	0.212		0		7.936		0.094
P值	0.645		1		0.005		0.749

EUS-FNA	性别		超声表现		病灶直径		病变部位
EUS-FNA	男(n＝59)	女(n＝23)	囊实混合性(n＝14)	实性(n＝68)	>2 cm(n＝74)	≤2 cm(n＝8)	胰头颈部(n＝58)	胰体尾部(n＝24)
阳性	44	16	10	50	58	2	43	17
阴性	15	7	4	18	16	6	15	7
χ²	0.212		0		7.936		0.094
P值	0.645		1		0.005		0.749

病灶直径	例数	阳性	阴性	准确率(%)	敏感性(%)	特异性(%)
>2 cm	74	58	16	90.5^a	92.0^a	100
≤2 cm	8	2	6	50.0	40.0	100

病灶直径	例数	阳性	阴性	准确率(%)	敏感性(%)	特异性(%)
>2 cm	74	58	16	90.5^a	92.0^a	100
≤2 cm	8	2	6	50.0	40.0	100

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