To study the clinical characteristics and the correlation between blood glucose metabolism and severity of acute pancreatitis with diabetes.

A total of 268 patients with acute pancreatitis admitted to Changchun Central Hospital from January 2020 to December 2022 were retrospectively collected.According to whether the patients had diabetes before, the patients were divided into diabetes group(n=90)and non diabetes group(n=178). The severity and blood glucose metabolism of the two groups were compared, and the correlation between blood glucose metabolism and the severity of acute pancreatitis was analyzed.

Compared with the non diabetes group, the proportion of patients with SOFA≥4 in the diabetes group was significantly higher(11.11% vs.3.93%, P=0.023); The proportion of patients required surgical drainage significantly increased(31.11% vs.15.17%, P=0.002); The fasting blood glucose significantly increased [(9.35±1.06)mmol/L vs.(5.38±0.82)mmol/L, P=0.000]; Glycated hemoglobin significantly increased [(8.31±1.41)% vs.(5.00±1.14)%, P=0.000]. Glycated hemoglobin had a good predictive value for patients with acute pancreatitis complicated with diabetes to develop to severe acute pancreatitis.The area under the curve was 0.828, 95% CI: 0.736-0.919, P=0.000.There was a positive correlation between fasting blood glucose, glycated hemoglobin and SOFA score(r=0.285, P=0.006; r=0.219, P=0.038).

Diabetes is a predictive index for the aggravation of acute pancreatitis.Controlling blood glucose metabolism may be helpful to improve the prognosis of patients with acute pancreatitis.