Application of dexmedetomidine combined with esketamine in painless gastroscopy in children

doi:10.3877/cma.j.issn.2095-2015.2023.06.030

Abstract

Abstract:

Objective

To explore the application effect of dexmedetomidine combined with esketamine in painless gastroscopy in children.

Methods

A total of 98 children who underwent painless gastroscopy examination in our hospital from May 2022 to May 2023 were selected as the study subjects.They were divided into a control group and an observation group according to different anesthesia plans.Among them, 48 cases in the control group were treated with propofol combined with esketamine anesthesia, and 50 cases in the observation group were treated with dexmedetomidine combined with esketamine anesthesia.The hemodynamic indicators and sedation scores of the two groups of children were compared before painless gastroscopy anesthesia(T0), at the beginning of surgery(T1), when gastroscopy entered the stomach(T2), and at the completion of surgery(T3). The cognitive function of the two groups was compared at T0, 10 minutes after awakening(T4), and 30 minutes after awakening(T5), and the recovery time of anesthesia(anesthesia onset time, awakening time, normal walking time)and the incidence of adverse reactions were recorded.

Results

The awakening time and normal walking time of the observation group were shorter than those of the control group(P<0.05); The T2, T3 mean arterial pressure(MAP), and heart rate(HR)levels in the control group increased(P<0.05), while the T2, T3 MAP and HR levels in the observation group were lower than those in the control group(P<0.05); There was no significant change in T0, T4 and T5 mini-mental state examination(MMSE)scores between the two groups(P>0.05); The T1-T3 Ramsay sedation scores in the observation group were lower than those in the control group(P<0.05); The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).

Conclusion

In painless gastroscopy examination of children, the combination of dexmedetomidine and esketamine has stable hemodynamics, good sedative effect, and reliable safety.

Key words: Dexmetomidine, Esketamine, Painless gastroscopy, Children

Zehui Huang, Jiexian Liang, Wei Zeng. Application of dexmedetomidine combined with esketamine in painless gastroscopy in children[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 510-513.

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References 15

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组别	例数	麻醉起效时间(min)	苏醒时间(min)	正常行走时间(h)
对照组	48	1.53±0.29	9.28±1.41	2.66±0.54
观察组	50	1.56±0.24	7.53±1.31	1.67±0.33
t		0.559	6.369	4.360
P		0.578	0.013	0.015

组别	例数	麻醉起效时间(min)	苏醒时间(min)	正常行走时间(h)
对照组	48	1.53±0.29	9.28±1.41	2.66±0.54
观察组	50	1.56±0.24	7.53±1.31	1.67±0.33
t		0.559	6.369	4.360
P		0.578	0.013	0.015

组别	例数	平均动脉压(mmHg)				心率(次/min)
组别	例数	T0	T1	T2	T3	T0	T1	T2	T3
对照组	48	68.17±6.23	69.12±6.48	78.47±6.82^a	79.20±6.72^a	100.13±10.46	101.28±9.30	110.05±6.20^a	113.73±5.21^a
观察组	50	69.93±6.28	68.08±6.63	71.72±6.72^b	70.93±6.79^b	100.68±10.50	99.10±9.48	102.26±9.03^b	100.82±10.18^b
t		0.528	0.371	4.698	3.285	0.830	0.425	4.839	5.190
P		0.239	0.412	0.013	0.019	0.092	0.184	0.017	0.002
组别	例数	血氧饱和度(%)
组别	例数	T0	T1	T2	T3
对照组	48	97.17±2.23	96.12±2.48	97.47±2.82	96.20±2.72
观察组	50	97.93±2.28	97.08±2.63	98.72±2.72	97.93±2.79
t		0.639	0.739	0.548	0.618
P		0.264	0.372	0.163	0.326

组别	例数	平均动脉压(mmHg)				心率(次/min)
组别	例数	T0	T1	T2	T3	T0	T1	T2	T3
对照组	48	68.17±6.23	69.12±6.48	78.47±6.82^a	79.20±6.72^a	100.13±10.46	101.28±9.30	110.05±6.20^a	113.73±5.21^a
观察组	50	69.93±6.28	68.08±6.63	71.72±6.72^b	70.93±6.79^b	100.68±10.50	99.10±9.48	102.26±9.03^b	100.82±10.18^b
t		0.528	0.371	4.698	3.285	0.830	0.425	4.839	5.190
P		0.239	0.412	0.013	0.019	0.092	0.184	0.017	0.002
组别	例数	血氧饱和度(%)
组别	例数	T0	T1	T2	T3
对照组	48	97.17±2.23	96.12±2.48	97.47±2.82	96.20±2.72
观察组	50	97.93±2.28	97.08±2.63	98.72±2.72	97.93±2.79
t		0.639	0.739	0.548	0.618
P		0.264	0.372	0.163	0.326

组别	例数	T0	T4	T5
对照组	48	27.82±2.21	27.71±2.03	27.17±2.06
观察组	50	27.71±2.18	27.84±2.09	27.93±2.10
t		0.143	0.128	0.013
P		0.068	0.682	0.743

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