To analyze the value of coagulation function index, blood lipid level, C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) in the activity evaluation and clinical diagnosis of Crohn's disease (CD).

A total of 197 patients with CD admitted to The Third Affiliated Hospital of Soochow University from January 2019 to June 2023 were included in CD group, and 50 healthy people were selected in the same period and included in control group. The levels of coagulation function, blood lipid, CRP and NLR were detected when the two groups entered the group, and the differences of the above indexes between patients with different CD activity index (CDAI) were compared. Receiver operating characteristic curve (ROC) was used to analyze the cutoff value, efficacy and area under curve (AUC) of coagulation function, blood lipid, CRP, NLR for evaluating CD activity and diagnosing CD.

Among 197 patients with CD, 130 (65.99%) were in active phase and 67 (34.01%) were in remission. APTT, FIB and INR in the CD group were higher than those in the control group; PT, FIB and INR in the active group were higher than those in the remission group, and their APTT, FIB and INR were higher than those in the control group. APTT, FIB and INR in the remission group were higher than those in the control group (P<0.05). TG, TC, LDL-C and HDL-C in the CD group were lower than those in the control group. TG, TC, LDL-C and HDL-C in the active group were lower than those in the remission group and control group (P<0.05). There was no statistically significant difference in blood lipid indicators between the remission group and control group (P>0.05). CRP and NLR in the CD group were higher than those in the control group; while the CRP and NLR in the active group were higher than those in the remission group and control group. The CRP and NLR in the remission group were higher than those in the control group (P<0.05). ROC curve showed that the AUC of coagulation function index, blood lipid, CRP and NLR combined to evaluate CD activity was 0.783, and the sensitivity and specificity were 80.44% and 81.97%, respectively. The AUC of diagnosing CD was 0.725, and the sensitivity and specificity were 76.71% and 78.44%, respectively.

There are obvious abnormalities in coagulation function, blood lipid level, CRP and NLR in CD patients, and the above pathological changes are more significant in active CD patients. Therefore, detecting these indexes can provide some reference for CD activity evaluation and clinical auxiliary diagnosis.