Diagnostic values of serum GDF15, sB7-H1 combined with multi-slice spiral CT perfusion imaging technology for lymph node metastasis in gastric cancer patients

doi:10.3877/cma.j.issn.2095-2015.2024.01.011

Abstract

Abstract:

Objective

Exploring the diagnostic values of serum growth differentiation factor 15 (GDF15), soluble B7-H1 (sB7-H1) combined with multi-slice spiral CT (MSCT) perfusion imaging for lymph node metastasis in gastric cancer patients.

Methods

A total of 96 gastric cancer patients admitted to Shandong Provincial Hospital from May 2021 to May 2023 were selected as the study group. Patients in the study group were divided into a metastatic group (41 cases) and a non metastatic group (55 cases) based on the presence or absence of lymph node metastasis. Additionally, 96 patients with benign gastric diseases during the same period were selected as the control group. The Spearman method was used to analyze the correlation between the expression levels of serum GDF15, sB7-H1 and MSCT parameters in patients; Logistic regression analysis was used to analyze the related factors affecting lymph node metastasis in gastric cancer patients; The diagnostic values of serum GDF15, sB7-H1 and MSCT parameters in lymph node metastasis of gastric cancer patients were analyzed using receiver operating characteristic (ROC) curve.

Results

There was a statistically significant difference in MSCT parameters among three groups (P<0.05); The expression levels of serum GDF15 and sB7-H1 in the metastatic group were higher than those in the control group and non metastatic group (P<0.05); The expression levels of serum GDF15 and sB7-H1 were negatively correlated with the blood volume (BV) and bleeding flow (BF) in the lesion area, and positively correlated with the mean transit time (MTT) and surface permeability (PS) of the contrast agent (P<0.05); The proportions of patients with tumors≥2 cm and infiltration depth in the submucosal layer in the metastatic group were significantly higher than those in the non metastatic group (P<0.05); Tumor size, depth of invasion, GDF15 and sB7-H1 were risk factors for lymph node metastasis in gastric cancer patients (P<0.05); The area under the curve (AUC) of serum GDF15, sB7-H1 and MSCT for diagnosing lymph node metastasis in gastric cancer patients were 0.867, 0.804, 0.740, 0.855, 0.580 and 0.655, respectively. The AUC of serum GDF15, sB7-H1 combined with MSCT was 0.965, which was superior to the separate detection of serum GDF15, SB7-H1 and MSCT (Z_{combined-GDF15}=2.788, Z_{combined-sB7-H1}=3.888, Z_combined-BV=4.837, Z_combined-MTT=3.255, Z_combined-BF=6.281, Z_combined-PS=5.529, all P<0.05).

Conclusion

The expression levels of serum GDF15 and sB7-H1 are closely related to the occurrence of lymph node metastasis in gastric cancer patients, and the combination of the two and MSCT has high diagnostic value for lymph node metastasis in gastric cancer patients.

Key words: Gastric cancer, Growth differentiation factor 15, Soluble B7-H1, Multi-slice spiral CT, Lymph node metastasis

Letian Yuan, Yilin Wang, Zijian Shen, Chengxin Yan. Diagnostic values of serum GDF15, sB7-H1 combined with multi-slice spiral CT perfusion imaging technology for lymph node metastasis in gastric cancer patients[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(01): 62-66.

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Figures/Tables 7

References 21

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组别	例数	BV(mL/100 mg)	MTT(s)	BF(mL/100 mg^-1·min^-1)	PS(mL/100 mg^-1·min^-1)
对照组	96	12.56±2.11	21.44±2.57	57.33±7.08	7.62±1.02
未转移组	55	10.31±1.85^a	23.95±2.80^a	49.16±5.79^a	8.09±1.37^a
转移组	41	9.06±1.23^ab	27.20±3.18^ab	45.08±5.23^ab	8.73±1.52^ab
F		57.793	63.470	62.956	11.673
P		0.000	0.000	0.000	0.000

组别	例数	BV(mL/100 mg)	MTT(s)	BF(mL/100 mg^-1·min^-1)	PS(mL/100 mg^-1·min^-1)
对照组	96	12.56±2.11	21.44±2.57	57.33±7.08	7.62±1.02
未转移组	55	10.31±1.85^a	23.95±2.80^a	49.16±5.79^a	8.09±1.37^a
转移组	41	9.06±1.23^ab	27.20±3.18^ab	45.08±5.23^ab	8.73±1.52^ab
F		57.793	63.470	62.956	11.673
P		0.000	0.000	0.000	0.000

组别	例数	GDF15(pg/mL)	sB7-H1(pg/mL)
对照组	96	70.22±7.73	68.14±7.56
未转移组	55	78.33±8.09^a	73.66±8.12^a
转移组	41	85.66±9.22^ab	81.94±8.93^ab
F		54.903	43.039
P		0.000	0.000

组别	例数	GDF15(pg/mL)	sB7-H1(pg/mL)
对照组	96	70.22±7.73	68.14±7.56
未转移组	55	78.33±8.09^a	73.66±8.12^a
转移组	41	85.66±9.22^ab	81.94±8.93^ab
F		54.903	43.039
P		0.000	0.000

组别	年龄		性别		肿瘤大小		浸润深度
组别	<60岁	≥60岁	男	女	<2 cm	≥2 cm	黏膜层	黏膜下层
例数	40	56	49	47	44	52	48	48
转移组(n=41)	17(42.50)	24(42.86)	23(46.94)	18(38.30)	11(25.00)	30(57.69)	13(27.08)	28(58.33)
未转移组(n=55)	23(57.50)	32(57.14)	26(53.06)	29(61.70)	33(75.00)	22(42.31)	35(72.92)	20(41.67)
χ²值	0.001		0.732		10.411		9.579
P值	0.972		0.392		0.001		0.002
组别	组织学分型			肿瘤位置			有无溃疡
组别	溃疡型	隆起型	凹陷型	上部	中部	下部	有	无
例数	34	24	38	33	30	33	65	31
转移组(n=41)	15(44.12)	10(41.67)	16(42.11)	11(33.33)	12(40.00)	18(54.55)	29(44.63)	12(38.71)
未转移组(n=55)	19(55.88)	14(58.33)	22(57.89)	22(66.67)	18(60.00)	15(45.45)	36(55.37)	19(61.29)
χ²值	0.044			3.165			0.299
P值	0.978			0.205			0.584

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