Current status of molecular mechanisms research and clinical applications in slow-transmission constipation

doi:10.3877/cma.j.issn.2095-2015.2024.01.015

Abstract

Abstract:

Chronic constipation is one of the most common gastrointestinal symptoms, and slow-transmission constipation (STC) is the most difficult to treat among all types of chronic constipation. STC is characterized by delayed colonic transmission without outlet obstruction and requires colectomy or subtotal resection when medication is difficult to treat. The etiology of STC is complex and the pathogenesis is not yet clear, and research has focused on pathological changes in the enteric nervous system, the gastrointestinal Cajal interstitial cell alterations, abnormalities in neurotransmitters and gastrointestinal hormones, and the effects of intestinal fluid absorption. Nowadays, many new research methods are flourishing, which are promising to provide new ideas for the in-depth study of the pathogenesis of STC.

Key words: Slow-transmission constipation, Molecular mechanism

Cen Huang, Yuekun Zhu. Current status of molecular mechanisms research and clinical applications in slow-transmission constipation[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(01): 82-89.

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