Relationship between intestinal flora characteristics and serum NSE，NO，IL-1 and IL-6 in children with mild gastroenteritis and benign convulsion

doi:10.3877/cma.j.issn.2095-2015.2025.02.013

Abstract

Abstract:

Objective

To investigate the characteristics of intestinal flora and the clinical significance of serum neuron-specific enolase （NSE），nitric oxide （NO），interleukin-1 （IL-1） and interleukin-6 （IL-6） in children with benign infantile convulsion associated with mild gastroenteritis（BICE）.

Methods

A total of 40 children with BICE treated in Yulin First Hospital from November 2022 to November 2023 were selected as the study group，and 40 children with mild gastroenteritis were selected as the control group. The levels of intestinal flora，serum NSE，NO，IL-1 and IL-6 in children with BICE were compared between the two groups，and the levels of intestinal flora，serum NSE，NO，IL-1 and IL-6 in children with BICE with different disease degrees and recurrence conditions were compared. Pearson correlation analysis was used to analyze the correlation between intestinal flora，serum NSE，NO，IL-1，IL-6 and disease and recurrence in children with BICE.

Results

The levels of Enterococcus，Escherichia coli，Lactobacillus and Bifidobacterium in the study group were lower than those in the control group，and serum NSE，NO，IL-1 and IL-6 were higher than those in the control group，with statistically significant differences （P＜0.05）. The levels of Enterococcus，Escherichia coli，Lactobacillus and Bifidobacterium in the intestinal flora of children with BICE in severe group were lower than those in normal group，and serum NSE，NO，IL-1 and IL-6 were higher than those in normal group，with statistically significant differences （P＜0.05）. The levels of Enterococcus，Escherichia coli，Lactobacillus and Bifidobacterium in the intestinal flora of children with BICE in the relapsed group were lower than those in the non-relapsed group，and the serum NSE，NO，IL-1 and IL-6 were higher than those in the non-relapsed group，with statistically significant differences （P＜0.05）. The results of Pearson correlation analysis showed that Enterococcus，Escherichia coli，Lactobacillus and Bifidobacterium were negatively correlated with disease and recurrence in children with BICE，while serum NSE，NO，IL-1 and IL-6 were positively correlated with disease and recurrence in children with BICE （P＜0.05）.

Conclusion

The changes of intestinal flora，serum NSE，NO，IL-1 and IL-6 in children with BICE are closely related to the severity and recurrence of the disease，and monitoring these indicators is helpful for early clinical intervention and treatment.

Key words: Mild gastroenteritis with benign convulsion in infants, Neuron specific enolase, Nitric oxide, Interleukin-1, Interleukin-6

Jie Liu, Maomao Ma, Xingxing Gao. Relationship between intestinal flora characteristics and serum NSE，NO，IL-1 and IL-6 in children with mild gastroenteritis and benign convulsion[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(02): 168-173.

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URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2025.02.013

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Figures/Tables 6

References 20

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组别	例数	肠球菌（CFU/g）	大肠杆菌（CFU/g）	乳酸杆菌（CFU/g）	双歧杆菌（CFU/g）	NSE（μg/L）	NO（μmol/L）	IL-1（pg/mL）	IL-6（pg/mL）
研究组	40	6.10±1.53	7.64±2.23	4.85±1.60	5.01±1.44	28.41±3.13	139.82±15.84	10.01±1.60	7.30±0.54
对照组	40	7.46±2.21	8.80±1.70	6.16±2.11	5.83±1.20	11.75±2.55	69.80±7.42	6.75±1.08	5.05±0.33
t 值		3.20	2.626	3.129	2.767	26.099	25.317	10.681	22.486
P 值		0.000	0.010	0.002	0.007	0.000	0.000	0.000	0.000

组别	例数	肠球菌（CFU/g）	大肠杆菌（CFU/g）	乳酸杆菌（CFU/g）	双歧杆菌（CFU/g）	NSE（μg/L）	NO（μmol/L）	IL-1（pg/mL）	IL-6（pg/mL）
研究组	40	6.10±1.53	7.64±2.23	4.85±1.60	5.01±1.44	28.41±3.13	139.82±15.84	10.01±1.60	7.30±0.54
对照组	40	7.46±2.21	8.80±1.70	6.16±2.11	5.83±1.20	11.75±2.55	69.80±7.42	6.75±1.08	5.05±0.33
t 值		3.20	2.626	3.129	2.767	26.099	25.317	10.681	22.486
P 值		0.000	0.010	0.002	0.007	0.000	0.000	0.000	0.000

组别	例数	肠球菌（CFU/g）	大肠杆菌（CFU/g）	乳酸杆菌（CFU/g）	双歧杆菌（CFU/g）	NSE（μg/L）	NO（μmol/L）	IL-1（pg/mL）	IL-6（pg/mL）
严重组	15	5.23±1.10	5.50±1.61	4.85±1.05	4.38±1.12	33.15±2.05	168.45±21.63	16.16±3.85	15.26±2.89
普通组	25	6.20±1.33	7.75±1.65	6.37±2.15	6.24±1.41	25.26±2.60	120.90±17.45	12.38±2.12	10.13±2.20
t 值		2.376	4.213	2.552	4.345	10.016	7.624	4.017	6.342
P 值		0.023	0.000	0.015	0.000	0.000	0.000	0.000	0.000

组别	例数	肠球菌（CFU/g）	大肠杆菌（CFU/g）	乳酸杆菌（CFU/g）	双歧杆菌（CFU/g）	NSE（μg/L）	NO（μmol/L）	IL-1（pg/mL）	IL-6（pg/mL）
严重组	15	5.23±1.10	5.50±1.61	4.85±1.05	4.38±1.12	33.15±2.05	168.45±21.63	16.16±3.85	15.26±2.89
普通组	25	6.20±1.33	7.75±1.65	6.37±2.15	6.24±1.41	25.26±2.60	120.90±17.45	12.38±2.12	10.13±2.20
t 值		2.376	4.213	2.552	4.345	10.016	7.624	4.017	6.342
P 值		0.023	0.000	0.015	0.000	0.000	0.000	0.000	0.000

组别	例数	肠球菌（CFU/g）	大肠杆菌（CFU/g）	乳酸杆菌（CFU/g）	双歧杆菌（CFU/g）	NSE（μg/L）	NO（μmol/L）	IL-1（pg/mL）	IL-6（pg/mL）
复发组	12	6.05±1.40	7.58±2.16	4.74±1.51	4.95±1.38	28.41±3.13	140.24±16.15	11.12±1.65	7.48±0.66
未复发组	28	9.10±2.24	10.11±2.03	8.34±2.35	6.81±1.44	11.75±2.55	70.15±7.80	6.50±1.10	5.11±0.42
t 值		4.348	3.545	4.873	3.789	17.683	18.643	10.431	13.700
P 值		0.000	0.001	0.000	0.001	0.000	0.000	0.000	0.000

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